Results 61 to 70 of about 4,367,929 (381)
Near-infrared light increases ATP, extends lifespan and improves mobility in aged Drosophila melanogaster. [PDF]
, 2015 Ageing is an irreversible cellular decline partly driven by failing mitochondrial integrity. Mitochondria accumulate DNA mutations and reduce ATP production necessary for cellular metabolism. This is associated with inflammation.
Begum, R +5 more
core +1 more source
Inflammation in atherosclerosis [PDF]
Nature, 2002 Experimental work has elucidated molecular and cellular pathways of inflammation that promote atherosclerosis. Unraveling the roles of cytokines as inflammatory messengers provided a mechanism whereby risk factors for atherosclerosis can alter arterial biology, and produce a systemic milieu that favors atherothrombotic events.
openaire +4 more sources
FEBS Letters, EarlyView.In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali +3 more
wiley +1 more source
Counteracting the effects of TNF receptor‐1 has therapeutic potential in Alzheimer's disease
EMBO Molecular Medicine, 2018 Alzheimer's disease (AD) is the most common form of dementia, and neuroinflammation is an important hallmark of the pathogenesis. Tumor necrosis factor (TNF) might be detrimental in AD, though the results coming from clinical trials on anti‐TNF ...
Sophie Steeland +14 more
doaj +1 more source
Roles of tumor suppressors in regulating tumor-associated inflammation. [PDF]
, 2014 Loss or silencing of tumor suppressors (TSs) promotes neoplastic transformation and malignant progression. To date, most work on TS has focused on their cell autonomous effects.
Karin, M, Yang, L
core +1 more source
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Endothelial Cells Potentially Participate in the Metastasis of Triple-Negative Breast Cancer
Journal of Immunology Research, 2022 Inhibition of triple-negative breast cancer metastasis has long been a challenge, mainly due to the difficulty in identifying factors that contribute to this process.
Yanfei Ma +14 more
doaj +1 more source
IL-6 in inflammation, immunity, and disease.
Cold Spring Harbor Perspectives in Biology, 2014 Interleukin 6 (IL-6), promptly and transiently produced in response to infections and tissue injuries, contributes to host defense through the stimulation of acute phase responses, hematopoiesis, and immune reactions.
Toshio Tanaka, M. Narazaki, T. Kishimoto
semanticscholar +1 more source
Role of pyroptosis in inflammation and cancer
Cellular & Molecular Immunology, 2022 Pyroptosis is a form of programmed cell death mediated by gasdermin and is a product of continuous cell expansion until the cytomembrane ruptures, resulting in the release of cellular contents that can activate strong inflammatory and immune responses ...
Xiang Wei +9 more
semanticscholar +1 more source
Targeting of reactive isolevuglandins in mitochondrial dysfunction and inflammation. [PDF]
, 2019 Inflammation is a major cause of morbidity and mortality in Western societies. Despite use of multiple drugs, both chronic and acute inflammation still represent major health burdens.
Amarnath, Venkataraman +10 more
core