Long-term risk factors of stoma construction after loose seton placement for Crohn disease–associated perianal fistulas [PDF]
Purpose To evaluate long-term outcomes and identify prognostic factors for stoma construction following loose seton placement in patients with Crohn disease (CD)-associated perianal fistulas.
Eiichi Nakao +6 more
doaj +1 more source
CCR2+ Macrophages Promote Orthodontic Tooth Movement and Alveolar Bone Remodeling
During mechanical force-induced alveolar bone remodeling, macrophage-mediated local inflammation plays a critical role. Yet, the detailed heterogeneity of macrophages is still unknown.
Hao Xu +21 more
doaj +1 more source
Glaucoma is seen in about 20% of the patients with uveitis. Anterior uveitis may be acute, subacute, or chronic. The mechanisms by which iridocyclitis leads to obstruction of aqueous outflow include acute, usually reversible forms (e.g., accumulation of inflammatory elements in the intertrabecular spaces, edema of the trabecular lamellae, or angle ...
Sonam A Bodh +4 more
openaire +3 more sources
Candidate genes colocalized to linkage regions in inflammatory bowel disease [PDF]
Background and Aims: The genes encoding for tumor necrosis factor-alpha (TNF-alpha), epidermal growth factor receptor (EGFR) and the vitamin D receptor (VDR) are colocalized to inflammatory bowel disease-associated linkage regions on chromosomes 6, 7 and
Folwaczny, Christian +4 more
core +1 more source
Management of Anal Fistula with Crohn's Disease
Crohn's disease (CD) causes gastrointestinal symptoms (i.e., diarrhea and abdominal pain), systemic symptoms (i.e., fatigue, anemia, weight loss, and fever), and perianal fistulas that produce anal pain. Because of the frequent occurrence of diarrhea and
Shota Takano +5 more
doaj +1 more source
Randomised controlled trial of screening for Chlamydia trachomatis to prevent pelvic inflammatory disease: the POPI (prevention of pelvic infection) trial. [PDF]
OBJECTIVE: To determine whether screening and treating women for chlamydial infection reduces the incidence of pelvic inflammatory disease over the subsequent 12 months. DESIGN: Randomised controlled trial.
Atherton, H +22 more
core +1 more source
Downregulation of Mcl-1 has anti-inflammatory pro-resolution effects and enhances bacterial clearance from the lung [PDF]
Phagocytes not only coordinate acute inflammation and host defense at mucosal sites, but also contribute to tissue damage. Respiratory infection causes a globally significant disease burden and frequently progresses to acute respiratory distress syndrome,
Tait, M A +10 more
core +1 more source
Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin +17 more
wiley +1 more source
Pro-inflammatory-NO+/ anti-inflammatory-CD206+ Kupffer cells ratio prior and after reperfusion.
Pro-inflammatory-NO+/ anti-inflammatory-CD206+ KCs ratio was lower in the RGZ treated group at all the studied time points. Significant lower ratio was found in the RGZ vs CTRL group since 1hr after reperfusion group (3.45±0.32 vs 5.68±0.37; p = 0.001 ...
Ivan Linares (5059373) +11 more
core +1 more source
Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways [PDF]
It is of considerable translational importance whether depression is a form or a consequence of sickness behavior. Sickness behavior is a behavioral complex induced by infections and immune trauma and mediated by pro-inflammatory cytokines.
Anderson, George +34 more
core +2 more sources

