Results 161 to 170 of about 6,114,519 (189)
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Role of hypoxia in inflammatory upper airway disease
Current Opinion in Allergy & Clinical Immunology, 2008Hypoxia is a potent stimulus for inflammation and remodeling. Hypoxia develops in chronic sinusitis as shown via tissue oxygen concentrations and colonization with obligate anaerobes. This hypoxia reflects occlusion of the sinus ostia and thereby failure of transepithelial oxygenation, nonvascularized exudates, and the tendency of inflammatory ...
John W, Steinke +2 more
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Novel therapies for the treatment of inflammatory airway disease
Expert Opinion on Investigational Drugs, 2003Asthma and chronic obstructive pulmonary disease (COPD) are diseases of the airways with an underlying inflammatory component. The prevalence and healthcare burden of asthma and COPD is still rising and is predicted to continue to rise in the current century.
David J, Hele, Maria G, Belvisi
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Neural control of the lower airways: Role in cough and airway inflammatory disease
2022Airway function is under constant neurophysiological control, in order to maximize airflow and gas exchange and to protect the airways from aspiration, damage, and infection. There are multiple sensory nerve subtypes, whose disparate functions provide a wide array of sensory information into the CNS.
Thomas E, Taylor-Clark, Bradley J, Undem
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Update on airways inflammatory diseases
2017In addition to genetic and environmental factors, airway inflammation is the result of the activation of innate and adaptive immune system, which, in turn, contributes to the onset of harmful structural changes affecting target tissues and leading to several diseases.
Manti, Sara, Leonardi, Salvatore
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Disease models of chronic inflammatory airway disease
Current Opinion in Pulmonary Medicine, 2014Purpose of reviewThis review will discuss methodologies and applicability of key inflammatory models of respiratory disease in proof of concept or proof of efficacy clinical studies. In close relationship with these models, induced sputum and inflammatory cell counts will be addressed for phenotype-directed drug development.
Diamant, Zuzana +3 more
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[COPD: an inflammatory disease of the airways?].
Pneumologie (Stuttgart, Germany), 2004COPD is characterized by a not fully reversible airflow limitation which is progressive and associated with an abnormal inflammatory reaction of the lungs. Airflow limitation is most often assessed by FEV (1.0). However, FEV (1.0) does not always reflect the course of the disease and does not appropriately describe the functional effect of a ...
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Role of inflammation and inflammatory mediators in airways disease
The American Journal of Medicine, 1986Recent evidence suggests that airway inflammation is linked to hyper-responsiveness of airway smooth muscle. Increases in airway responsiveness after many stimuli are accompanied by increases in inflammatory cells in bronchoalveolar lavage fluid and in the airway epithelium.
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The role of the epithelium in chronic inflammatory airway disease
Pulmonary Pharmacology & Therapeutics, 2012Paul L, Dudas +3 more
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