Results 171 to 180 of about 158,758 (202)
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Chronic Macrolide Therapy in Inflammatory Airways Diseases
Chest, 2010Long-term therapy with the macrolide antibiotic erythromycin was shown to alter the clinical course of diffuse panbronchiolitis in the late 1980s. Since that time, macrolides have been found to have a large number of antiinflammatory properties in addition to being antimicrobials.
Adam L, Friedlander, Richard K, Albert
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Role of hypoxia in inflammatory upper airway disease
Current Opinion in Allergy & Clinical Immunology, 2008Hypoxia is a potent stimulus for inflammation and remodeling. Hypoxia develops in chronic sinusitis as shown via tissue oxygen concentrations and colonization with obligate anaerobes. This hypoxia reflects occlusion of the sinus ostia and thereby failure of transepithelial oxygenation, nonvascularized exudates, and the tendency of inflammatory ...
John W, Steinke +2 more
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Nitric oxide in upper airways inflammatory diseases
Inflammation Research, 2007In the human respiratory tract, the main production sites of exhaled nitric oxide (NO) are the nose and paranasal sinuses. In the upper airways, NO has been suggested to be involved at different levels with regulatory, protective, defensive or deleterious effects.
Mauro Maniscalco +2 more
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Neural control of the lower airways: Role in cough and airway inflammatory disease
2022Airway function is under constant neurophysiological control, in order to maximize airflow and gas exchange and to protect the airways from aspiration, damage, and infection. There are multiple sensory nerve subtypes, whose disparate functions provide a wide array of sensory information into the CNS.
Thomas E, Taylor-Clark, Bradley J, Undem
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The Spectrum of Nonasthmatic Inflammatory Airway Diseases in Adults
Otolaryngologic Clinics of North America, 2010When the airways are overwhelmed by noxious particles, gases, or microorganisms, inflammatory and immune responses occur that may cause permanent structural changes. One consequence may be an overproduction of mucus and this may overwhelm mucociliary clearance mechanisms and cause a chronic cough phlegm syndrome. The expectorated mucus is usually clear
Sidney S, Braman, Muhanned, Abu-Hijleh
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Update on airways inflammatory diseases
2017In addition to genetic and environmental factors, airway inflammation is the result of the activation of innate and adaptive immune system, which, in turn, contributes to the onset of harmful structural changes affecting target tissues and leading to several diseases.
Manti, Sara, Leonardi, Salvatore
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Update on Noninfectious Inflammatory Diseases of the Lower Airway
Veterinary Clinics of North America: Equine Practice, 2015Inflammatory airway disease and recurrent airway obstruction are 2 nonseptic diseases of the equine respiratory system with a shared cause of exposure to particulate matter. They appear to occupy 2 ends of a spectrum of disease, but are differentiated by history, clinical signs, and response to treatment.
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Disease models of chronic inflammatory airway disease
Current Opinion in Pulmonary Medicine, 2014Purpose of reviewThis review will discuss methodologies and applicability of key inflammatory models of respiratory disease in proof of concept or proof of efficacy clinical studies. In close relationship with these models, induced sputum and inflammatory cell counts will be addressed for phenotype-directed drug development.
Diamant, Zuzana +3 more
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Role of inflammation and inflammatory mediators in airways disease
The American Journal of Medicine, 1986Recent evidence suggests that airway inflammation is linked to hyper-responsiveness of airway smooth muscle. Increases in airway responsiveness after many stimuli are accompanied by increases in inflammatory cells in bronchoalveolar lavage fluid and in the airway epithelium.
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[COPD: an inflammatory disease of the airways?].
Pneumologie (Stuttgart, Germany), 2004COPD is characterized by a not fully reversible airflow limitation which is progressive and associated with an abnormal inflammatory reaction of the lungs. Airflow limitation is most often assessed by FEV (1.0). However, FEV (1.0) does not always reflect the course of the disease and does not appropriately describe the functional effect of a ...
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