Results 21 to 30 of about 1,052,402 (298)

Safety of Janus Kinase Inhibitors in Patients with Inflammatory Bowel Diseases or Other Immune-mediated Diseases: a Systematic Review and Meta-Analysis.

Gastroenterology, 2020
BACKGROUND & AIMS Inhibitors of Janus kinases (JAKs) are being developed for treatment of inflammatory bowel diseases and other immune-mediated diseases. Tofacitinib is effective in treatment of ulcerative colitis, but there are safety concerns.
P. Olivera, J. Lasa, S. Bonovas, S. Danese, L. Peyrin-Biroulet   +4 more
semanticscholar   +1 more source

Antifibrogenic Effects of the Antimicrobial Peptide Cathelicidin in Murine Colitis-Associated FibrosisSummary

Cellular and Molecular Gastroenterology and Hepatology, 2015
Background & Aims: Cathelicidin (LL-37 in human and mCRAMP in mice) represents a family of endogenous antimicrobial peptides with anti-inflammatory effects.
Jun Hwan Yoo, Samantha Ho, Deanna Hoang-Yen Tran, Michelle Cheng, Kyriaki Bakirtzi, Yuzu Kubota, Ryan Ichikawa, Bowei Su, Diana Hoang-Ngoc Tran, Tressia C. Hing, Irene Chang, David Q. Shih, Richard E. Issacson, Richard L. Gallo, Claudio Fiocchi, Charalabos Pothoulakis, Hon Wai Koon   +16 more
doaj   +1 more source

Prevalence and predictors of non-alcoholic liver disease on MRI among patients with Crohn's disease

BMC Gastroenterology, 2022
Background It has been documented that Crohn’s disease (CD) patients were prone to develop non-alcoholic liver fatty liver disease (NAFLD) with less metabolic factors.
Qijin Hong, Jun Shen, Qi Feng, Qing Zheng, Yuqi Qiao   +4 more
doaj   +1 more source

SARS-CoV-2 IgG Antibody Levels in Women with IBD Vaccinated during Pregnancy

Vaccines, 2022
Introduction: Regulatory agencies supported vaccination of pregnant women with SARS-CoV-2 mRNA vaccines, including patients with IBD. No data exist regarding these vaccines in IBD during pregnancy.
Irit Avni Biron, Yair Maayan, Tali Mishael, Eran Hadar, Michal Neeman, Romina Plitman Mayo, Hen Y. Sela, Simcha Yagel, Rosalind Goldenberg, Ami Ben Ya’acov, Sorina Grisaru Granovsky, Jacob E. Ollech, Hadar Edelman-Klapper, Keren Masha Rabinowitz, Maor H. Pauker, Henit Yanai, Sophy Goren, Dani Cohen, Iris Dotan, Ariella Bar-Gil Shitrit   +19 more
doaj   +1 more source

Nutritional Aspects in Inflammatory Bowel Diseases

Nutrients, 2020
Crohn’s disease (CD) and ulcerative colitis (UC) are chronic, relapsing, inflammatory disorders of the digestive tract that characteristically develop in adolescence and early adulthood.
P. Balestrieri, M. Ribolsi, M. Guarino, S. Emerenziani, A. Altomare, M. Cicala   +5 more
semanticscholar   +1 more source

Features of Crohn's Disease Depending on the Age of Disease Onset

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2023
Aim: to evaluate the characteristics of Crohn's disea depending on the age of the disease onset in patients observed in a specialized City Center for Inflammatory Bowel Diseases Diagnosis and Treatment.Materials and methods. We observed 180 patients with
E. G. Ganich, O. B. Shchukina
doaj   +1 more source

The microbiome in inflammatory bowel diseases: from pathogenesis to therapy

Protein & Cell, 2020
Inflammatory bowel disease (IBD) has become a global disease with accelerating incidence worldwide in the 21st century while its accurate etiology remains unclear.
Sheng Liu, Wenjing Zhao, P. Lan, Xiangyu Mou   +3 more
semanticscholar   +1 more source

Substance P Mediates Proinflammatory Cytokine Release From Mesenteric Adipocytes in Inflammatory Bowel Disease PatientsSummary

Cellular and Molecular Gastroenterology and Hepatology, 2015
Background & Aims: Substance P (SP) neurokinin-1 receptors (NK-1Rs) are expressed in mesenteric preadipocytes, and SP binding activates proinflammatory signaling in these cells. We evaluated the expression levels of SP (Tac-1), NK-1R (Tacr-1), and NK-2R (
Aristea Sideri, Kyriaki Bakirtzi, David Q. Shih, Hon Wai Koon, Phillip Fleshner, Razvan Arsenescu, Violeta Arsenescu, Jerrold R. Turner, Iordanes Karagiannides, Charalabos Pothoulakis   +9 more
doaj   +1 more source

Identification of a Novel Substance P–Neurokinin-1 Receptor MicroRNA-221-5p Inflammatory Network in Human Colonic Epithelial CellsSummary

Cellular and Molecular Gastroenterology and Hepatology, 2015
Background & Aims: Substance P (SP), a neuropeptide member of the tachykinin family, plays a critical role in colitis. MicroRNAs (miRNAs) are small noncoding RNAs that negatively regulate gene expression.
Kai Fang, Aristea Sideri, Ivy Ka Man Law, Kyriaki Bakirtzi, Christos Polytarchou, Dimitrios Iliopoulos, Charalabos Pothoulakis   +6 more
doaj   +1 more source

Environmental Risk Factors for Inflammatory Bowel Diseases: an Umbrella Review of Meta-analyses.

Gastroenterology, 2019
BACKGROUND & AIMS Multiple environmental factors have been associated with development of inflammatory bowel diseases (IBD). We performed an umbrella review of meta-analyses to summarize available epidemiologic evidence and assess its credibility ...
D. Piovani, S. Danese, L. Peyrin-Biroulet, G. Nikolopoulos, T. Lytras, S. Bonovas   +5 more
semanticscholar   +1 more source