Results 41 to 50 of about 387,427 (329)

DR3 Regulates Intestinal Epithelial Homeostasis and Regeneration After Intestinal Barrier InjurySummary

Cellular and Molecular Gastroenterology and Hepatology, 2023
Background & Aims: Tumor necrosis factor (TNF) superfamily member tumor necrosis factor–like protein 1A (TL1A) has been associated with the susceptibility and severity of inflammatory bowel diseases. However, the function of the tumor necrosis factor–
Yosuke Shimodaira, Shyam K. More, Hussein Hamade, Anna Y. Blackwood, Jay P. Abraham, Lisa S. Thomas, Jordan H. Miller, Dalton T. Stamps, Sofi L. Castanon, Noam Jacob, Connie W.Y. Ha, Suzanne Devkota, David Q. Shih, Stephan R. Targan, Kathrin S. Michelsen   +14 more
doaj  

Impact of the first wave of COVID-19 on Crohn’s disease after the end of “zero-COVID” policy in China

Frontiers in Public Health, 2023
BackgroundThe incidence and severity of coronavirus disease 2019 (COVID-19) among Crohn’s disease (CD) patients are unknown in China. This study aimed to clarify the clinical courses and outcomes of CD patients in the first COVID-19 wave after the end of
Wen Hu, Xiao Li, Zelin Yan, Qiuzhi Wang, Jiakai Luo, Qiao Yu, Shuyan Li, Shiyuan Lu, Atiyeh Roozbahani, Ehsan Ghoushi, Yan Chen, Jun Li   +11 more
doaj   +1 more source

Cutaneous Manifestations in Inflammatory Bowel Diseases [PDF]

, 2015
Inflammatory bowel diseases have a high frequency in Europe. They are chronic disorders that evolve with relapses and remissions. Clinical features include the signs of underlying inflammatory bowel disease and also signs of extraintestinal ...
Benea, Vasile, Costescu, Monica, Georgescu, Simona Roxana, Mitran, Cristina Iulia, Mitran, Madalina Irina, Sarbu, Maria Isabela, Tampa, Mircea   +6 more
core   +2 more sources

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Biomarkers as Potential Treatment Targets in Inflammatory Bowel Disease: A Systematic Review

Canadian Journal of Gastroenterology and Hepatology, 2015
There is increasing interest in the concept of ‘treat-to-target’ in inflammatory bowel disease as a mechanism to standardize management and prevent complications. While clinical, radiographic and endoscopic treatment end points will figure prominently in
Travis B Murdoch, Sarah O’Donnell, Mark S Silverberg, Remo Panaccione   +3 more
doaj   +1 more source

Helminths in the gastrointestinal tract 1 as modulators of immunity and pathology [PDF]

, 2017
Helminth parasites are highly prevalent in many low- and middle-income countries, in which inflammatory bowel disease and other immunopathologies are less frequent than in the developed world.
Fleming, John O., Maizels, Richard, Varyani, Fumi   +2 more
core   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases. [PDF]

, 2019
Inflammatory bowel diseases, which include Crohn's disease and ulcerative colitis, affect several million individuals worldwide. Crohn's disease and ulcerative colitis are complex diseases that are heterogeneous at the clinical, immunological, molecular,
Ajami, Nadim J, Ananthakrishnan, Ashwin N, Andrews, Elizabeth, Arze, Cesar, Avila-Pacheco, Julian, Bonham, Kevin S, Braun, Jonathan, Brislawn, Colin J, Casero, David, Clish, Clary B, Courtney, Holly, Denson, Lee A, Franzosa, Eric A, Gonzalez, Antonio, Graeber, Thomas G, Hall, A Brantley, Huttenhower, Curtis, IBDMDB Investigators, Jansson, Janet K, Knight, Rob, Kugathasan, Subra, Lake, Kathleen, Landers, Carol J, Lloyd-Price, Jason, Mallick, Himel, McGovern, Dermot PB, Petrosino, Joseph F, Plichta, Damian R, Poon, Tiffany W, Prasad, Mahadev, Rahnavard, Gholamali, Sauk, Jenny, Schirmer, Melanie, Shungin, Dmitry, Stappenbeck, Thaddeus S, Vlamakis, Hera, Vázquez-Baeza, Yoshiki, White, Richard A, Winter, Harland S, Xavier, Ramnik J   +39 more
core  

Roles of GM-CSF in the Pathogenesis of Autoimmune Diseases: An Update. [PDF]

, 2019
Granulocyte-macrophage colony-stimulating factor (GM-CSF) was first described as a growth factor that induces the differentiation and proliferation of myeloid progenitors in the bone marrow.
Adorini, Ahn, Alnek, Ananthakrishnan, Aram, Aricha, Basdeo, Bernasconi, Bezbradica, Bhattacharya, Bhattacharya, Bogunovic, Borriello, Campbell, Cao, Casciola-Rosen, Cheatem, Chiewchengchol, Choi, Chuang, Ciric, Codarri, Cook, Cook, Coombes, Croxford, Denson, Derouet, Dieckgraefe, Duhen, Egea, El-Behi, Enzler, Fernandes, Fillatreau, Fraussen, Fuchs, Ganesan, Ganesh, Gangi, Gao, Gathungu, Gaudreau, Ghosh, Gonzalez, Gopisetty, Hansen, Harrington, Hartmann, Hirota, Hirota, Hirota, Huang, Imitola, Jain, Kared, Karni, Kaskow, Katano, Katz, Kelly, Kenkel, King, King, Kister, Lebre, Lee, Lehtonen, Leizer, Li, Li, Li, Li, Makris, Marks, Matsuyama, Mausberg, McWilliams, Meriggioli, Midgley, Mikita, Mufazalov, Muranski, Nagane, Noster, Ortega, Parajuli, Pare, Pare, Park, Piper, Ponomarev, Poppensieker, Ramos-Levi, Rasouli, Reynolds, Roelofs, Rowin, Sakaguchi, Salehi, Samarpita, Scholz, Schutt, Serafini, Shang, Shapouri-Moghaddam, Sheng, Sheng, Sheng, Shiomi, Shiomi, Shiomi, Smith, Srenathan, Stojic-Vukanic, Surendar, Tavakolpour, Touil, Tsark, van de Laar, van Nieuwenhuijze, Vasu, Vincent, Vincent, Vogel, Waisman, Wicks, Wiggins-Dohlvik, Willeke, Xu, Xu, Yang, York, Zhang, Zhao   +134 more
core   +2 more sources

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source