Results 51 to 60 of about 428,528 (325)

Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases. [PDF]

, 2019
Inflammatory bowel diseases, which include Crohn's disease and ulcerative colitis, affect several million individuals worldwide. Crohn's disease and ulcerative colitis are complex diseases that are heterogeneous at the clinical, immunological, molecular,
Ajami, Nadim J, Ananthakrishnan, Ashwin N, Andrews, Elizabeth, Arze, Cesar, Avila-Pacheco, Julian, Bonham, Kevin S, Braun, Jonathan, Brislawn, Colin J, Casero, David, Clish, Clary B, Courtney, Holly, Denson, Lee A, Franzosa, Eric A, Gonzalez, Antonio, Graeber, Thomas G, Hall, A Brantley, Huttenhower, Curtis, IBDMDB Investigators, Jansson, Janet K, Knight, Rob, Kugathasan, Subra, Lake, Kathleen, Landers, Carol J, Lloyd-Price, Jason, Mallick, Himel, McGovern, Dermot PB, Petrosino, Joseph F, Plichta, Damian R, Poon, Tiffany W, Prasad, Mahadev, Rahnavard, Gholamali, Sauk, Jenny, Schirmer, Melanie, Shungin, Dmitry, Stappenbeck, Thaddeus S, Vlamakis, Hera, Vázquez-Baeza, Yoshiki, White, Richard A, Winter, Harland S, Xavier, Ramnik J   +39 more
core  

Microbiota and chronic inflammatory arthritis. an interwoven link [PDF]

, 2016
Background: Only recently, the scientific community gained insights on the importance of the intestinal resident flora for the host's health and disease.
D'Amelio, Raffaele, Laganà, Bruno, Manuela Rosado, M, Picchianti Diamanti, Andrea   +3 more
core   +2 more sources

Inflammatory bowel diseases [PDF]

Jornal de Pediatria, 2000
OBJECTIVE: To present a review about inflammatory bowel diseases in childhood so that pediatricians become familiar with two diseases (ulcerative colitis and Crohn s disease) that are increasing in incidence. METHODS: Articles of specific gastroenterological journals were analyzed.
openaire   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Mesenteric fat proliferation on magnetic resonance enterography is a predictor of long-term disease complications in crohn’s disease

BMC Gastroenterology
Background Fibrofatty proliferation of mesenteric fat is a common finding on magnetic resonance enterography (MRE) in Crohn’s disease (CD) patients. Mesenteric fat may play a role in inflammation, fibrosis, and stricture formation, but its prognostic ...
Eduard Koifman, Inna Spector Cohen, Rebeca Lopez-Alonso, Dana Ben Hur, Anat Ilivitzki, Matti Waterman   +5 more
doaj   +1 more source

A Replicating Single-Cycle Adenovirus Vaccine Effective against Clostridium difficile

Vaccines, 2020
Clostridium difficile causes nearly 500,000 infections and nearly 30,000 deaths each year in the U.S., which is estimated to cost $4.8 billion. C. difficile infection (CDI) arises from bacteria colonizing the large intestine and releasing two toxins ...
William E. Matchett, Stephanie Anguiano-Zarate, Goda Baddage Rakitha Malewana, Haley Mudrick, Melissa Weldy, Clayton Evert, Alexander Khoruts, Michael Sadowsky, Michael A. Barry   +8 more
doaj   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Meta-analysis of gene expression disease signatures in colonic biopsy tissue from patients with ulcerative colitis

Scientific Reports, 2021
Publicly available ulcerative colitis (UC) gene expression datasets from observational studies and clinical trials include inherently heterogeneous disease characteristics and methodology. We used meta-analysis to identify a robust UC gene signature from
Bryan Linggi, Vipul Jairath, Guangyong Zou, Lisa M. Shackelton, Dermot P. B. McGovern, Azucena Salas, Bram Verstockt, Mark S. Silverberg, Shadi Nayeri, Brian G. Feagan, Niels Vande Casteele   +10 more
doaj   +1 more source

EFSUMB Recommendations and Guidelines for Gastrointestinal Ultrasound - Part 1: Examination Techniques and Normal Findings (Long version). [PDF]

, 2016
▼ In October 2014 the European Federation of Societies for Ultrasound in Medicine and Biology formed a Gastrointestinal Ultrasound (GIUS) task force group to promote the use of GIUS in a clinical setting.
Calabrese, E., Dietrich, C. F., Dirks, K., Gilja, O. H., Hausken, T., Higginson, A., Hollerweger, A., Maaser, C., Maconi, G., Nuernberg, D., Nylund, K., Pallotta, Nadia, Ripolles, T., Romanini, L., Saftoiu, A., Serra, C., Sporea, I.   +16 more
core   +3 more sources