Results 1 to 10 of about 5,026,038 (351)

NETs Promote Inflammatory Injury by Activating cGAS-STING Pathway in Acute Lung Injury

International Journal of Molecular Sciences, 2023
Acute respiratory distress syndrome (ARDS) threatens the survival of critically ill patients, the mechanisms of which are still unclear. Neutrophil extracellular traps (NETs) released by activated neutrophils play a critical role in inflammatory injury ...
Jie Zhao, Ningxin Zhen, Qi-chao Zhou, Jian Lou, W. Cui, Gensheng Zhang, Bao-Ping Tian   +6 more
semanticscholar   +3 more sources

Acidosis, Iron Dyshomeostasis and Inflammatory Injury. [PDF]

Int J Mol Sci
Normal steps in uptake of non-heme iron by the gastrointestinal tract include ferrireduction and import across the apical enterocyte membrane by divalent metal transporter 1 (DMT1), responsible for the uptake of non-transferrin bound iron (NTBI).
Ingrassia R, Ghio AJ, Garrick M.
europepmc   +2 more sources

Yizong Tongluo formula attenuates idiopathic pulmonary fibrosis and inflammatory injury by inhibiting HIF-1α/LSH/SCD1-mediated ferroptosis [PDF]

Frontiers in Immunology
BackgroundIdiopathic pulmonary fibrosis (IPF) is a progressive disease characterized by chronic inflammation, aberrant tissue remodeling, and hypoxia. In traditional Chinese medicine (TCM), it is classified as Qi deficiency–blood stasis syndrome.
Xin Ma, Xin Wang, Daobin Jiang, Yiminnuer Tuerxun, Siming Tao, Fengsen Li, Yanrong Wei, Liu Yang, Lei Xi, Ling Wang   +9 more
doaj   +2 more sources

Research on Sinomenine Inhibiting the cGAS-STING Signaling Pathway to Alleviate Renal Inflammatory Injury in db/db Mice [PDF]

Pharmaceuticals
Objectives: This study aims to elucidate the potential molecular mechanism of Sinomenine (SIN) in treating renal injury in Diabetic Nephropathy (DN) through network pharmacology, molecular docking, and in vivo validation.
Xiaofei Jin, Tongtong He, Tianci Zhang, Xiaorong Wang, Xiangmei Chen, Bin Cong, Weijuan Gao   +6 more
doaj   +2 more sources

Circulating Mitochondrial DAMPs Cause Inflammatory Responses to Injury [PDF]

Nature, 2009
Injury causes a systemic inflammatory response syndrome (SIRS) that is clinically much like sepsis. Microbial pathogen-associated molecular patterns (PAMPs) activate innate immunocytes through pattern recognition receptors. Similarly, cellular injury can
Qin Zhang, Mustafa Raoof, Yu Chen, Y. Sumi, T. Sursal, W. Junger, K. Brohi, K. Itagaki, C. Hauser   +8 more
semanticscholar   +3 more sources

inlF Enhances Listeria monocytogenes Early-Stage Infection by Inhibiting the Inflammatory Response

Frontiers in Cellular and Infection Microbiology, 2022
The internalin family proteins, which carry the leucine repeat region structural motif, play diverse roles in Listeria monocytogenes (Lm) infection and pathogenesis.
Zhiting Ling, Zhiting Ling, Zhiting Ling, Zhiting Ling, Dan Zhao, Dan Zhao, Dan Zhao, Dan Zhao, Xinyu Xie, Xinyu Xie, Xinyu Xie, Xinyu Xie, Hao Yao, Hao Yao, Hao Yao, Hao Yao, Yuting Wang, Yuting Wang, Yuting Wang, Yuting Wang, Suwei Kong, Suwei Kong, Suwei Kong, Suwei Kong, Xiang Chen, Xiang Chen, Xiang Chen, Xiang Chen, Zhiming Pan, Zhiming Pan, Zhiming Pan, Zhiming Pan, Xin’an Jiao, Xin’an Jiao, Xin’an Jiao, Xin’an Jiao, Yuelan Yin, Yuelan Yin, Yuelan Yin, Yuelan Yin   +39 more
doaj   +1 more source

Low-Molecular-Weight Chitosan Attenuates Lipopolysaccharide-Induced Inflammation in IPEC-J2 Cells by Inhibiting the Nuclear Factor-κB Signalling Pathway

Molecules, 2021
Low-molecular-weight chitosan (LMWC), a product of chitosan deacetylation, possesses anti-inflammatory effects. In the present study, a porcine small intestinal epithelial cell line, IPEC-J2, was used to assess the protective effects of LMWC on ...
Jiao Zhang, Jin Wan, Daiwen Chen, Bing Yu, Jun He   +4 more
doaj   +1 more source

MSC-ACE2 Ameliorates Streptococcus uberis-Induced Inflammatory Injury in Mammary Epithelial Cells by Upregulating the IL-10/STAT3/SOCS3 Pathway

Frontiers in Immunology, 2022
In the dairy industry, Streptococcus uberis (S. uberis) is one of the most important pathogenic bacteria associated with mastitis in milk-producing cows, causing vast economic loss.
Shuping Yan, Chonghao Zhang, Xiaoxia Ji, Gang Wu, Xinhe Huang, Yafeng Zhang, Yuanshu Zhang   +6 more
doaj   +1 more source

Research progress on influence of PM2.5 on allergic rhinitis

环境与职业医学, 2023
Allergic rhinitis (AR) is one of the main chronic inflammatory diseases that pose a global threat. Its symptoms persist for a long time, recur, and seriously affect the physical and mental health of the patients.
Ying ZHANG, Ling HE, Huai WEI, Weidong WU, Juan LI   +4 more
doaj   +1 more source

Recent Advances in the Role of Nuclear Factor Erythroid-2-Related Factor 2 in Spinal Cord Injury: Regulatory Mechanisms and Therapeutic Options

Frontiers in Aging Neuroscience, 2022
Nuclear factor erythroid-2-related factor 2 (Nrf2) is a pleiotropic transcription factor, and it has been documented that it can induce defense mechanisms both oxidative stress and inflammatory injury.
Tianqi Jiang, Tianqi Jiang, Yongxiong He
doaj   +1 more source