Results 11 to 20 of about 5,026,038 (351)

Inflammatory neuroprotection following traumatic brain injury [PDF]

Science, 2016
Traumatic brain injury (TBI) elicits an inflammatory response in the central nervous system (CNS) that involves both resident and peripheral immune cells. Neuroinflammation can persist for years following a single TBI and may contribute to neurodegeneration.
Matthew V, Russo, Dorian B, McGavern
openaire   +4 more sources

mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury.

Immunity, 2020
Cytosolic DNA acts as a universal danger-associated molecular pattern (DAMP) signal; however, the mechanisms of self-DNA release into the cytosol and its role in inflammatory tissue injury are not well understood. We found that the internalized bacterial
L. Huang, Z. Hong, Wei Wu, Shiqin Xiong, Ming Zhong, Xiao‐pei Gao, J. Rehman, A. Malik   +7 more
semanticscholar   +3 more sources

Phagocyte-derived catecholamines enhance acute inflammatory injury [PDF]

Nature, 2007
It is becoming increasingly clear that the autonomic nervous system and the immune system demonstrate cross-talk during inflammation by means of sympathetic and parasympathetic pathways. We investigated whether phagocytes are capable of de novo production of catecholamines, suggesting an autocrine/paracrine self-regulatory mechanism by catecholamines ...
Flierl, Michael A., Rittirsch, Daniel, Nadeau, Brian A., Chen, Anthony J., Sarma, J. Vidya, Zetoune, Firas S., McGuire, Stephanie R., List, Rachel P., Day, Danielle E., Hoesel, Laszlo M., Gao, Hongwei, Van Rooijen, Nico, Huber-Lang, Markus S., Neubig, Richard R., Ward, Peter A.   +14 more
openaire   +5 more sources

FUT2-dependent fucosylation of HYOU1 protects intestinal stem cells against inflammatory injury by regulating unfolded protein response

Redox Biology, 2023
The intestinal epithelial repair after injury is coordinated by intestinal stem cells (ISCs). Fucosylation catalyzed by fucosyltransferase 2 (FUT2) of the intestinal epithelium is beneficial to mucosal healing but poorly defined is the influence on ISCs.
Zhe Wang, Chen Tan, Caihan Duan, Junhao Wu, Dan Zhou, Lingzhi Hou, W. Qian, Chaoqun Han, X. Hou   +8 more
semanticscholar   +1 more source

Scutellaria baicalensis georgi is a promising candidate for the treatment of autoimmune diseases

Frontiers in Pharmacology, 2022
Autoimmune diseases a group of disorders elicited by unexpected outcome of lymphocytes self-tolerance failure, and the common members of which include multiple sclerosis, systemic lupus erythematosus, inflammatory bowel disease, rheumatoid arthritis, and
Jun Wang, Shanshan Chen, Jizhou Zhang, Jiasi Wu   +3 more
doaj   +1 more source

lnc001776 Affects CPB2 Toxin-Induced Excessive Injury of Porcine Intestinal Epithelial Cells via Activating JNK/NF-kB Pathway through ssc-let-7i-5p/IL-6 Axis

Cells, 2023
Piglet diarrhea caused by Clostridium perfringens (C. perfringens) type C (CpC) seriously endangers the development of the pig production industry. C. perfringens beta2 (CPB2) toxin is a virulent toxin produced by CpC.
Kaihui Xie, Zunqiang Yan, Qiaoli Yang, Xiaoyu Huang, Pengfei Wang, Xiaoli Gao, Jie Li, Shuangbao Gun   +7 more
doaj   +1 more source

Luteolin suppresses TNF-α-induced inflammatory injury and senescence of nucleus pulposus cells via the Sirt6/NF-κB pathway

Experimental and Therapeutic Medicine, 2022
Luteolin (3',4',5,7-tetrahydroxy flavone) is a flavonoid, which is widely distributed in various plants including flowers, vegetables, and medicinal herbs and spices.
Tian Xie, Jun Yuan, L. Mei, Ping Li, Ruijie Pan   +4 more
semanticscholar   +1 more source

Inflammatory Biomarkers of Traumatic Brain Injury

Pharmaceuticals, 2022
Traumatic brain injury (TBI) has a complex pathology in which the initial injury releases damage associated proteins that exacerbate the neuroinflammatory response during the chronic secondary injury period. One of the major pathological players in the inflammatory response after TBI is the inflammasome. Increased levels of inflammasome proteins during
Nathan H. Johnson, Roey Hadad, Ruby Rose Taylor, Javier Rodríguez Pilar, Osman Salazar, Juan Antonio Llompart-Pou, W. Dalton Dietrich, Robert W. Keane, Jon Pérez-Bárcena, Juan Pablo de Rivero Vaccari   +9 more
openaire   +4 more sources

Mmu_circ_0000037 inhibits the progression of acute pancreatitis by miR‐92a‐3p/Pias1 axis

Immunity, Inflammation and Disease, 2023
Background Acute pancreatitis (AP) is an inflammatory disease with high mortality. Previous study has suggested that circular RNAs are dysregulated and involved in the regulation of inflammatory responses in AP.
Hua Chen, Jun Tu, Lei He, Ning Gao, Weiqiang Yang   +4 more
doaj   +1 more source

Adhesion molecules and inflammatory injury [PDF]

The FASEB Journal, 1994
Neutrophil‐endothelial cell interactions are mediated by interacting sets of cell adhesion molecules (CAMs) and chemoattractant/activator molecules to form an “adhesion cascade.” The initial phase of inflammation, a transient slowing of neutrophils in postcapillary venules, is mediated by selectins.
Albelda, Steven M., Smith, C. Wayne, Ward, Peter A.   +2 more
openaire   +3 more sources