Results 21 to 30 of about 5,026,038 (351)

VX-765 attenuates silica-induced lung inflammatory injury and fibrosis by modulating alveolar macrophages pyroptosis in mice.

Ecotoxicology and Environmental Safety, 2022
Silicosis is a diffuse fibrotic lung disease in which excessive inflammatory responses are triggered by silica exposure. Pyroptosis, a pro-inflammatory mode of programmed cell death, is mediated by gasdermin and may play a pivotal role in the development
Huihui Tao, Hui Zhao, Aowei Mo, Luocheng Shao, Deyong Ge, Jiale Liu, Wenjian Hu, Keyi Xu, Qianqian Ma, Wenfeng Wang, Wenyang Wang, Hangbing Cao, M. Mu, Xinrong Tao, Jianhua Wang   +14 more
semanticscholar   +1 more source

GSDMD-miR-223-NLRP3 axis involved in B(a)P-induced inflammatory injury of alveolar epithelial cells.

Ecotoxicology and Environmental Safety, 2022
Benzo(a)pyrene [B(a)P], a ubiquitous environmental pollutant, causes lung inflammatory damage. Pyroptosis，a new inflammation-dependent programmed cell death, happened when pyroptosis-related GSDMD is activated mediated by NLRP3 inflammasome. microRNA-223
Xiangbing Kong, M. Gao, Yitong Liu, P. Zhang, Mengyuan Li, P. Ma, Pingping Shang, W. Wang, Hong Liu, Qiao Zhang, Feifei Feng   +10 more
semanticscholar   +1 more source

Heat shock proteins took part in oxidative stress-mediated inflammatory injury via NF-κB pathway in excess manganese-treated chicken livers.

Ecotoxicology and Environmental Safety, 2021
Manganese (Mn) is an essential metal in humans and animals. However, excess Mn entered environment due to the wide application of Mn in industry and agriculture, and became an environmental pollutant.
Yuhao Liu, Meijin Yu, J. Cui, Ye Du, X. Teng, Zuozhong Zhang   +5 more
semanticscholar   +1 more source

Traumatic brain injury‐related inflammatory projection: beyond local inflammatory responses [PDF]

Acute Medicine & Surgery, 2020
Acute neuroinflammation induced by microglial activation is key for repair and recovery after traumatic brain injury (TBI) and could be necessary for the clearance of harmful substances, such as cell debris. However, recent clinical and preclinical data have shown that TBI causes chronic neuroinflammation, lasting many years in some cases, and leading ...
Sanae Hosomi, Mitsuo Ohnishi, Hiroshi Ogura, Takeshi Shimazu   +3 more
openaire   +2 more sources

Global Gene Expression Analysis Identifies Age-Related Differences in Knee Joint Transcriptome during the Development of Post-Traumatic Osteoarthritis in Mice. [PDF]

, 2020
Aging and injury are two major risk factors for osteoarthritis (OA). Yet, very little is known about how aging and injury interact and contribute to OA pathogenesis.
Christiansen, Blaine A, Hum, Nicholas R, Loots, Gabriela G, McCool, Jillian L, Mendez, Melanie E, Murugesh, Deepa K, Rios-Arce, Naiomy D, Sebastian, Aimy   +7 more
core   +2 more sources

Macrophages exert homeostatic actions in pregnancy to protect against preterm birth and fetal inflammatory injury

JCI Insight, 2021
Macrophages are commonly thought to contribute to the pathophysiology of preterm labor by amplifying inflammation — but a protective role has not previously been considered to our knowledge. We hypothesized that given their antiinflammatory capability in
N. Gomez‐Lopez, V. Garcia-Flores, P. Chin, Holly M. Groome, Melanie T. Bijland, K. Diener, R. Romero, S. Robertson   +7 more
semanticscholar   +1 more source

Oral administration of Lactobacillus brevis 23017 combined with ellagic acid attenuates intestinal inflammatory injury caused by Eimeria infection by activating the Nrf2/HO-1 antioxidant pathway

Veterinary Research, 2022
The aim of this study was to investigate whether oral administration of Lactobacillus brevis 23017 (LB) alone and in combination with ellagic acid inhibits ChTLR15/ChNLRP3/ChIL-1β by activating the Nrf2/HO-1 pathway to attenuate intestinal inflammatory ...
Xuelian Yang, Xinghui Pan, Zhipeng Jia, Bingrong Bai, Wenjing Zhi, Hang Chen, Chunli Ma, Dexing Ma   +7 more
doaj   +1 more source

Enforced expression of miR-92b blunts E. coli lipopolysaccharide-mediated inflammatory injury by activating the PI3K/AKT/β-catenin pathway via targeting PTEN

International Journal on Biological Sciences, 2021
Endometritis is a reproductive disorder characterized by an inflammatory response in the endometrium, which causes significant economic losses to the dairy farming industry.
Kangfeng Jiang, Jing Yang, Chunlian Song, Fengping He, Liangyu Yang, Xiaobing Li   +5 more
semanticscholar   +1 more source

Inflammatory response to infectious pulmonary injury [PDF]

European Respiratory Journal, 2003
This review describing the inflammatory response to infectious pulmonary injury is focused on the innate immunity of the distal lung to bacterial pneumonia. The fact that the inflammatory response varies to some extent with the bacterial strain responsible for the infection is emphasised.
C, Delclaux, E, Azoulay
openaire   +2 more sources

The uncoordinated-5 homolog B receptor affects hepatic ischemia reperfusion injury [PDF]

, 2012
Recent evidence has demonstrated additional roles for the neuronal guidance protein receptor UNC5B outside the nervous system. Given the fact that ischemia reperfusion injury (IRI) of the liver is a common source of liver dysfunction and the role of ...
Granja, Tiago, Jennewein, Carla, Kröhnert, Friedemann, Köhler, David, König, Klemens, Mirakaj, Valbona, Rosenberger, Peter, Tran, Thi Hoai Nguyen   +7 more
core   +7 more sources