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Inflammatory Response to Brain Injury

2001
Historically, it was believed that the central nervous system (CNS) fails to mount an inflammatory response due to its protection from the systemic immune system mediated by the blood-brain barrier (BBB). However, in the last decades, participation of neuronal and glial cells in inflammatory events occurring in infectious, autoimmune and degenerative ...
Maria Cristina Morganti-Kossmann   +4 more
openaire   +1 more source

Inflammatory Response to Pulmonary Ischemia–Reperfusion Injury

Surgery Today, 2006
Lung ischemia-reperfusion (IR) injury is one of the most important complications following lung transplant and cardiopulmonary bypass. The pulmonary dysfunction following lung IR has been well documented. Recent studies have shown that ischemia and reperfusion of the lung may each play significant yet differing roles in inducing lung injury.
Calvin S H, Ng   +3 more
openaire   +2 more sources

The inflammatory response to injury in children

Current Opinion in Pediatrics, 2010
Severely injured children have a decreased incidence and different pattern of multiple organ failure when compared with adults. This article reviews recent advances in understanding the mechanisms leading to this discrepancy.Post injury, inflammation-related outcomes are age-related, as demonstrated by epidemiological and laboratory investigations that
James H, Wood   +2 more
openaire   +2 more sources

Long non‐coding RNA THRIL promotes LPS‐induced inflammatory injury by down‐regulating microRNA‐125b in ATDC5 cells

International Immunopharmacology, 2019
Background: Osteoarthritis is an age‐related disorder of bone‐joint that causes pain and disability in middle and older people. This study aimed to investigate the potential effects of long non‐coding RNA (lncRNA) THRIL on lipopolysaccharide (LPS ...
Guang-yao Liu   +3 more
semanticscholar   +1 more source

Acute inflammatory demyelination in reperfusion nerve injury

Annals of Neurology, 2000
We investigated the pathological appearance of acute inflammation and its role in the development of demyelination in reperfused rat sciatic, tibial, and peroneal nerves after a 5-hour period of near-complete ischemia. Polymorphonuclear neutrophil migration was seen early in the endoneurial lesion.
H, Nukada, P D, McMorran, J, Shimizu
openaire   +2 more sources

Liquiritigenin and liquiritin alleviated monocrotaline-induced hepatic sinusoidal obstruction syndrome via inhibiting HSP60-induced inflammatory injury.

Toxicology, 2019
Hepatic sinusoidal obstruction syndrome (HSOS) is a life-threatening liver disease caused by the damage to liver sinusoidal endothelial cells (LSECs). Liquiritigenin and liquiritin are two main compounds in Glycyrrhizae Radix et Rhizoma (Gan-cao).
Zhenlin Huang   +4 more
semanticscholar   +1 more source

Kaempferol protects chondrogenic ATDC5 cells against inflammatory injury triggered by lipopolysaccharide through down‐regulating miR‐146a

International Immunopharmacology, 2019
&NA; Kaempferol is a kind of bioflavonoid exerts diverse pharmacological activities, including anti‐apoptotic and anti‐inflammatory activities. Kaempferol has been recognized as an effective agent for alleviating the clinical symptoms of osteoarthritis ...
R. Jiang   +6 more
semanticscholar   +1 more source

Inflammatory cell response to acute muscle injury

Medicine & Science in Sports & Exercise, 1995
Nonmuscle cells play central roles in muscle repair and regeneration during the inflammation that follows muscle injury, although many aspects of the mechanisms by which inflammatory cells are attracted to injury sites and activated are unknown. Current evidence indicates that substances released from injured muscle can act as "wound hormones" that ...
openaire   +2 more sources

Verbascoside attenuates acute inflammatory injury in experimental cerebral hemorrhage by suppressing TLR4.

Biochemical and Biophysical Research Communications - BBRC, 2019
Cerebral hemorrhage (ICH) is a common cerebrovascular condition with high mortality, disability and recurrence rates. TLR4-mediated acute inflammatory injury plays a pivotal role in ICH.
Xue Lai   +6 more
semanticscholar   +1 more source

Nonsteroidal Anti-Inflammatory Drugs and Gastroduodenal Injury

American Journal of Therapeutics, 1998
Nonsteroidal anti-inflammatory drugs (NSAIDs) are a commonly prescribed and over-the-counter class of drugs in the United States, with widespread use for various indications. The increased risk of gastrointestinal toxicity with the use of nonsteroidal medications has been well recognized.
Kumar Venkat   +4 more
openaire   +2 more sources

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