Results 301 to 310 of about 5,026,038 (351)

Idebenone attenuates cerebral inflammatory injury in ischemia and reperfusion via dampening NLRP3 inflammasome activity.

Molecular Immunology, 2020
BACKGROUND Idebenone is a well-appreciated mitochondrial protectant while the mechanisms underlying the neuroprotection in cerebral ischemia and reperfusion (I/R) remain elusive.
Jialing Peng, Hongxuan Wang, Zhe Gong, Xiang-pen Li, Lei He, Qingyu Shen, Jingrui Pan, Ying Peng   +7 more
semanticscholar   +1 more source

Inflammatory Pathways in Spinal Cord Injury

2012
Injury to the spinal cord results in direct damage to axons, neuronal cell bodies, and glia that cause functional loss below the site of injury. In addition, the injury also triggers an inflammatory response that contributes to secondary tissue damage that leads to further functional loss.
Samuel, David, Juan Guillermo, Zarruk, Nader, Ghasemlou   +2 more
openaire   +2 more sources

Lipopolysaccharide-induced inflammatory liver injury in mice

Laboratory Animals, 2015
The intraperitoneal application of lipopolysaccharide (LPS) alone or in combination with other hepatotoxins is an experimental model for inducing systemic and hepatic inflammation in rodents applied worldwide. The endotoxin is recognized by the LPS-binding protein.
K, Hamesch, E, Borkham-Kamphorst, P, Strnad, R, Weiskirchen   +3 more
openaire   +2 more sources

Macrophages and Inflammatory Mediators in Tissue Injury

Annual Review of Pharmacology and Toxicology, 1995
Tissue injury induced by a diverse group of xenobiotics appears to involve both direct and indirect damage to target cells. Thus, while chemicals may act directly on target cells resulting in toxicity, they may also act indirectly by recruiting and activating resident and inflammatory tissue macrophages.
D L, Laskin, K J, Pendino
openaire   +2 more sources

Exercise, injury and chronic inflammatory lesions

British Medical Bulletin, 1992
The increasing frequency of injury over the last two decades reflects the activities of a more exercise conscious public. However, all too often injury may be due to ill-advised or inappropriate exercise and can be prevented by relatively simple modification of technique, equipment or gait abnormalities.
openaire   +2 more sources

Nonsteroid anti-inflammatory drug-induced gastroduodenal injury

Current Opinion in Gastroenterology, 2009
This article reviews selected publications related to nonsteroid anti-inflammatory drug (NSAID)-induced gastroduodenal toxicity in recent years.This article provides a comprehensive review of the latest evidence on the epidemiology of NSAID-induced gastroduodenal injury, recommendations on optimal gastroprotective regimens among patients in need of ...
Larry H, Lai, Francis K L, Chan
openaire   +2 more sources

Inflammatory Cells in Renal Injury and Repair

Seminars in Nephrology, 2007
Renal inflammation may result from a myriad of insults and often is characterized by the presence of infiltrating inflammatory leukocytes within the glomerulus or tubulointerstitium. Accumulating evidence indicates that infiltrating leukocytes are key players in the induction of renal injury.
David, Ferenbach, David C, Kluth, Jeremy, Hughes   +2 more
openaire   +2 more sources

Dual faced HMGB1 plays multiple roles in cardiomyocyte senescence and cardiac inflammatory injury.

Cytokine & growth factor reviews, 2019
High mobility group box 1 (HMGB1) is constitutively expressed by many cells. In cells, HMGB1 is a transcription factor or transcription enhancer that is involved in nucleosome sliding, DNA repair, V(D)J recombination, telomere homeostasis, autophagy and ...
Hongxiang Lu, Zhenzhen Zhang, P. A. Barnie, Zhaoliang Su   +3 more
semanticscholar   +1 more source

Exosomes in Sepsis and Inflammatory Tissue Injury

Current Pharmaceutical Design, 2020
:Sepsis is the leading cause of death in medical intensive care units, and thus represents a serious healthcare problem worldwide. Sepsis is often caused by the aberrant host responses to infection, which induce dysregulated inflammation that leads to life-threatening multiple organ failures.
Eun J. Park, Michael G. Appiah, Phyoe K. Myint, Arong Gaowa, Eiji Kawamoto, Motomu Shimaoka   +5 more
openaire   +2 more sources

The inflammatory injury of heart caused by ammonia is realized by oxidative stress and abnormal energy metabolism activating inflammatory pathway.

Science of the Total Environment, 2020
Inflammation is an essential biological process for maintaining homeostasis in the body. However, excessive inflammatory response is closely related to many chronic diseases.
Huan Wang, Yu Zhang, Q. Han, Yanmin Xu, Guanghui Hu, H. Xing   +5 more
semanticscholar   +1 more source