Results 51 to 60 of about 2,794,554 (162)

Interference of protein tyrosine phosphatase non-receptor type 22 inhibits NLRP3 inflammasome activation to alleviate inflammation after cerebral hemorrhage in rats

Di-san junyi daxue xuebao, 2019
Objective To investigate the role of protein tyrosine phosphatase non-receptor type 22 (PTPN22) in inflammatory response following intracerebral hemorrhage (ICH) in rats and explore the mechanism that mediates its effect.
WANG Lu, ZHANG Li, XIAO Han, GAN Hui, CHEN Hui   +4 more
doaj   +1 more source

RETRACTED: lncRNA‐PDPK2P promotes hepatocellular carcinoma progression through the PDK1/AKT/Caspase 3 pathway

Molecular Oncology, 2019
Hepatocellular carcinoma (HCC) is a malignancy with one of the worst prognoses. Long noncoding RNA (lncRNA) are emerging as an important regulator of gene expression and function, leading to the development of cancer.
Weidong Pan, Wen Li, Jun Zhao, Zhiyi Huang, Jingyuan Zhao, Shuxian Chen, Chusi Wang, Youqiu Xue, Feng Huang, Qiannan Fang, Julie Wang, David Brand, Song Guo Zheng   +12 more
doaj   +1 more source

Simvastatin attenuates inflammatory process on LPS-induced acute lung injury in mice. [PDF]

, 2023
Acute lung injury (ALI) is a disease of high prevalence and is characterized by the excessive production of inflammatory mediators in the lungs of people sick.
Antunes, Géssica Luana, Bastos, Matheus Scherer, de Oliveira, Jarbas Rodrigues, Luft, Carolina, Silveira, Josiane, Matzenbacher, Lucas Strasburger, Gracia-Sancho, Jordi, Kaiber, Daniela Benvenutti, da Costa, Mariana Severo, Pedrazza, Leonardo, de Souza Basso, Bruno, Jarbas Rodrigues de Oliveira, Garcia, Maria Claudia, Levorse, Vitor Giancarlo Schneider, Rodrigues, Ketlin Fernanda, Denizar Alberto da Silva Melo, Donadio, Márcio Vinícius Fagundes, MATZENBACHER, LUCAS STRASSBURGER, Haute, Gabriela Viegas, Melo, Denizar, Márcio Vinícius Fagundes Donadio, Daniela Benvenutti Kaiber, Gabriela Viegas Haute, Matheus Scherer Bastos, Carolina Luft, Leonardo Pedrazza, Géssica Luana Antunes, Vitor Giancarlo Schneider Levorse, Ketlin Fernanda Rodrigues, Maria Claudia Garcia, Mariana Severo da Costa, Jordi Gracia-Sancho, Josiane Silveira, Denizar Melo, Lucas Strassburger Matzenbacher, Bruno de Souza Basso   +35 more
core   +2 more sources

Tea Polyphenol Protects the Immune Barrier and Inhibits TLR2/NF-κB/MLCK Signal Activation to Prevent Inflammatory Injury in the Intestines of Common Carp (Cyprinus carpio L.)

Animals
Tea polyphenol (TP) is a kind of natural macromolecular compound present in tea extract with rich biological potential. The purpose of this study was to explore the protective effect of TP on the intestinal immune barrier and the related mechanisms of TP
Man Qian, Jie Yang, Yao Xue, Jiawei Wu, Ziyi Li, Jilong Luo, Bing Zhao, Xuejiao Gao   +7 more
doaj   +1 more source

Mechanisms of Lung Injury in a Mouse Model of Bronchopulmonary Dysplasia [PDF]

, 2009
Bronchopulmonary dysplasia (BPD) is a chronic lung disease that affects preterm infants. Increased levels of inflammatory mediators in the amniotic fluid and in the lungs of preterm infants are associated with the development of BPD.
Hogmalm, Anna
core  

Spinal cord trauma and the molecular point of no return [PDF]

, 2012
A mechanical trauma to the spinal cord can be followed by the development of irreversible and progressive neurodegeneration, as opposed to a temporary or partially reversible neurological damage.
Yip, PK, Malaspina Andrea, Andrea Malaspina, Yip Ping K, Malaspina, A, Ping K Yip   +5 more
core   +1 more source

Ginsenoside F1 Ameliorates Endothelial Cell Inflammatory Injury and Prevents Atherosclerosis in Mice through A20-Mediated Suppression of NF-kB Signaling

Frontiers in Pharmacology, 2017
Atherosclerosis (AS) is a chronic inflammatory disease and endothelial cell injury is the initial event. In this study, we investigated the protective effects of ginsenoside F1 (GF1) on AS and the potential molecular mechanisms of ox-LDL induced ...
Meng Qin, Meng Qin, Meng Qin, Meng Qin, Yun Luo, Yun Luo, Yun Luo, Yun Luo, Shan Lu, Shan Lu, Shan Lu, Shan Lu, Jing Sun, Ke Yang, Guibo Sun, Guibo Sun, Guibo Sun, Guibo Sun, Xiaobo Sun, Xiaobo Sun, Xiaobo Sun, Xiaobo Sun   +21 more
doaj   +1 more source

Mechanisms involved in chronic neuropathic pain after avulsion injury [PDF]

, 2010
PhDMotor vehicle accidents are the most common cause of injuries involving avulsion of spinal roots from the brachial or lumbosacral plexuses. This results in chronic intractable pain that is refractory to pharmacotherapy.
Chew, Daniel John
core  

CpG oligonucleotide activates Toll-like receptor 9 and causes lung inflammation in vivo [PDF]

, 2007
Background Bacterial DNA containing motifs of unmethylated CpG dinucleotides (CpG-ODN) initiate an innate immune response mediated by the pattern recognition receptor Toll-like receptor 9 (TLR9).
Schwederski Markus, Koch, Alexander, Schwederski, Markus, Ehrentraut Heidi, Baumgarten, Georg, Ehrentraut, Heidi, Hoeft, Andreas, Velten, Markus, Knüfermann, Pascal, Zacharowski Kai, Hoeft Andreas, Mersmann Jan, Knuefermann Pascal, Meyer Rainer, Grohé Christian, Baumgarten Georg, Zacharowski, Kai, Koch Alexander, Meyer, Rainer, Grohé, Christian, Velten Markus, Mersmann, Jan   +21 more
core   +1 more source

Research on Sinomenine Inhibiting the cGAS-STING Signaling Pathway to Alleviate Renal Inflammatory Injury in db/db Mice

Pharmaceuticals
Objectives: This study aims to elucidate the potential molecular mechanism of Sinomenine (SIN) in treating renal injury in Diabetic Nephropathy (DN) through network pharmacology, molecular docking, and in vivo validation.
Xiaofei Jin, Tongtong He, Tianci Zhang, Xiaorong Wang, Xiangmei Chen, Bin Cong, Weijuan Gao   +6 more
doaj   +1 more source