Results 101 to 110 of about 998,241 (312)

Community-based trial of screening for Chlamydia trachomatis to prevent pelvic inflammatory disease: the POPI (prevention of pelvic infection) trial. [PDF]

, 2008
BACKGROUND: Pelvic inflammatory disease (PID) is common and can lead to tubal factor infertility, ectopic pregnancy or chronic pelvic pain. Despite major UK government investment in the National Chlamydia Screening Programme, evidence of benefit remains ...
Atherton, H, Simms Ian, Simms, Ian, Pippa Oakeshott, Taylor-Robinson, David, Adamma Aghaizu, Kerry Sally, Oakeshott Pippa, Hay Phillip, Ian Simms, Kerry, S, Aghaizu, A, Taylor-Robinson David, Aghaizu, Adamma, Kerry, Sally M., Hay, Sima, Hay Sima, Aghaizu Adamma, Taylor-Robinson, D, Hay, Phillip, David Taylor-Robinson, Oakeshott, Pippa, Helen Atherton, Oakeshott, P, Hay, S, Atherton Helen, Atherton, Helen, Kerry, Sally, Hay, P, Sima Hay, Simms, I, Phillip Hay, Sally Kerry   +32 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Effects of fatty acids on inflammatory markers studies in vitro and in vivo

, 2008
Inflammation involves interactions amongst many different cell types as a defense mechanism of the body. Inflammation is also involved in cardiovascular disease (CVD).
Mohd Yusof, Hayati
core  

Ethnic variation in inflammatory profile in tuberculosis [PDF]

, 2013
Distinct phylogenetic lineages of Mycobacterium tuberculosis (MTB) cause disease in patients of particular genetic ancestry, and elicit different patterns of cytokine and chemokine secretion when cultured with human macrophages in vitro.
Bothamley, GH, Baker Lucy V., Nikolayevskyy, V, Barker, Richard D., Adrian R. Martineau (136644), Heather J Milburn, Drobniewski, Francis A., Nuamah, RA, Martineau, AR, Timms Peter M., Francis A. Drobniewski (349928), Coussens, Anna K., Griffiths, CJ, Vladyslav Nikolayevskyy, Drobniewski, FA, Bhaw-Rosun, L, Rosamond A. Nuamah (430904), Kamrul Islam (430894), Coussens Anna K., Francis A Drobniewski, Milburn, HJ, Davidson Robert N., Nuamah Rosamond A., Alleyna P Claxton, Charles A Mein, Yasmeen Hanifa, Yasmeen Hanifa (430893), Drobniewski Francis A., Elkington, Paul T., Graham H. Bothamley (430896), Claxton Alleyna P., Graham H Bothamley, Elkington Paul T., Peter M. Timms (430895), Anna K. Coussens (430892), Davidson, Robert N., Vladyslav Nikolayevskyy (349919), Bhaw-Rosun Leena, Milburn, Heather, Martineau, Adrian R., Paul T. Elkington (364501), Packe, Geoffrey E., Mein, Charles A., Young, Douglas B., Geoffrey E Packe, Martineau Adrian R., Islam, Kamrul, Packe, GE, Mathina Darmalingam, Anna K Coussens, Robert N Davidson, Mathina Darmalingam (430899), Timms, Peter M., Rosamond A Nuamah, Hanifa, Yasmeen, Elkington, PT, Lucy V. Baker (430901), Nikolayevskyy, Vladyslav, Bothamley, Graham H., Richard D. Barker (430902), Milburn, Heather J., Leena Bhaw-Rosun (430903), Robert J Wilkinson, Baker, Lucy V., Darmalingam, M, Wilkinson, Robert J., Christopher J Griffiths, Bothamley Graham H., Robert J. Wilkinson (130050), Hanifa Yasmeen, Claxton, Alleyna P., Kamrul Islam, Darmalingam Mathina, Barker, RD, Peter M Timms, Wilkinson Robert J., Griffiths Christopher J., Islam Kamrul, Nuamah, Rosamond A., Hanifa, Y, Packe Geoffrey E., Barker Richard D., Claxton, AP, Alleyna P. Claxton (430897), Robert N. Davidson (364270), Coussens, AK, Timms, PM, Paul T Elkington, Christopher J. Griffiths (430905), Leena Bhaw-Rosun, Davidson, RN, Milburn Heather J., Griffiths, Christopher J., Lucy V Baker, Geoffrey E. Packe (430898), Richard D Barker, Darmalingam, Mathina, Nikolayevskyy Vladyslav, Heather J. Milburn (430900), Mein, CA, Charles A. Mein (46734), Baker, LV, Wilkinson, RJ, Adrian R Martineau, Mein Charles A., Bhaw-Rosun, Leena, Islam, K   +106 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Novel biomarkers for prediabetes, diabetes, and associated complications

Diabetes, Metabolic Syndrome and Obesity, 2017
Brenda Dorcely,1 Karin Katz,1 Ram Jagannathan,2 Stephanie S Chiang,1 Babajide Oluwadare,1 Ira J Goldberg,1 Michael Bergman1 1New York University School of Medicine, Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, NYU Langone ...
Dorcely B, Katz K, Jagannathan R, Chiang SS, Oluwadare B, Goldberg IJ, Bergman M   +6 more
doaj  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Diagnosis, treatment and immunopathogenesis of the HIV-associated tuberculosis immune reconstitution inflammatory syndrome

, 2011
The paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is a frequent complication of antiretroviral therapy (ART) among patients who start ART while on treatment for tuberculosis (TB).
Meintjes, Graeme
core