Results 81 to 90 of about 1,347,839 (304)

Plasma total antioxidant capacity and peroxidation biomarkers in psoriasis [PDF]

, 2016
Systemic biomarkers of oxidative stress can be relevant for assessment of psoriasis severity, for prediction of the outcome of therapy and of the development of comorbidities.
Cavaliere, Arturo, Palmery, Maura, Peluso, Ilaria   +2 more
core   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Berry Fruit Extracts as Topical Cosmeceuticals for Skin Health Applications: A Systematic Review

Cosmetics
Berries are a popular source of natural bioactive compounds with distinctive aspects and sensory attributes. In this review, the term “berry” refers to generally round, small, colorful, and juicy fruits with English common names ending in “berry”.
Filipe Silveira Azevedo, Allan Rodrigues Pires, Mary Ann Lila, Giuseppe Valacchi, Roberta Targino Hoskin, Mariaurea Matias Sarandy, Rômulo Dias Novaes, Reggiani Vilela Goncalves   +7 more
doaj   +1 more source

Characterization of distinct subpopulations of hepatic macrophages in HFD/obese mice. [PDF]

, 2014
The current dogma is that obesity-associated hepatic inflammation is due to increased Kupffer cell (KC) activation. However, recruited hepatic macrophages (RHMs) were recently shown to represent a sizable liver macrophage population in the context of ...
Bandyopadhyay, Gautam, Bogner-Strauss, Juliane G, Chi, Tyler J, Chung, Heekyung, Evans, Ronald M, Franck, Niclas, Hah, Nasun, Heinrichsdorff, Jan, Mayoral, Rafael, Morinaga, Hidetaka, Oh, Da Young, Olefsky, Jerrold M, Osborn, Olivia, Pessentheiner, Ariane R, Walenta, Evelyn   +14 more
core   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

GENDER FEATURES OF INTERACTION HORMONAL ACTIVITY ADIPOSE TISSUE AND PROINFLAMMATORY STATUS IN HYPERTENSION WITH METABOLIC SYNDROME

Бюллетень сибирской медицины, 2014
Objective: research gender features of relationship of hormonal activity of adipose tissue and proinflammatory status with essential hypertension (EH) in combination with metabolic syndrome (MS).Material and methods.
I. D. Bespalova, N. V. Ryazantseva, V. V. Kalyuzhin, I. A. Osikhov, B. Yu. Murashev, Yu. A. Medyantsev, V. A. Rudnitsky   +6 more
doaj   +1 more source

Anti-Saccharomyces cerevisiae antibodies in patients with inflammatory bowel disease and their first-degree relatives: Potential clinical value [PDF]

, 2002
Anti-Saccharomyces cerevisiae antibodies (ASCA) have been described as specific markers in Crohn's disease and their healthy first-degree relatives. 171 patients with Crohn's disease, their 105 first-degree relatives, 145 patients with ulcerative colitis
Folwaczny, Christian, Glas, J., Herbinger, K. H., Hoelscher, Michael, Török, H.-P., Vilsmaier, F.   +5 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Monocyte-to-high-density lipoprotein cholesterol ratio is associated with the presence and size of thyroid nodule irrespective of the gender

Lipids in Health and Disease, 2020
Background Systemic inflammation may be involved in the formation and progression of thyroid nodule (TN). The aim of this large-scale study was to investigate the association of several simple inflammatory markers with the presence and size of TN ...
Xing Zhen Liu, Jun Min Wang, Yi Xin Ji, Dong Bao Zhao   +3 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source