Results 231 to 240 of about 145,258 (308)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Detecting bias in algorithms used to disseminate information in social networks and mitigating it using multiobjective optimization. [PDF]

PNAS Nexus
Sekara V, Dotu I, Cebrian M, Moro E, Garcia Herranz M.   +4 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Analysing celebrity and influencer marketing of food and beverages to adolescents on Instagram. [PDF]

Public Health Nutr
Khan R, Tanweer A, Suggs LS.
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Molecular testing and other metrics in thyroid cytology as quality-assurance measures in evaluating variation among pathologists in the diagnosis of atypia of undetermined significance. [PDF]

Cancer Cytopathol
Elsheikh TM, Sheen C, Bell T, Booth C, Doxtader EE, Hamadeh F, Underwood D, Yang L, Chaari R.   +8 more
europepmc   +1 more source

Evaluating the quality, reliability, and diagnostic risk of ADHD content on TikTok and Bilibili: A cross-sectional content analysis. [PDF]

Digit Health
Yu WX, Li ZB, Shao XY, Cai WJ, Wang M, Yang CH, Lu W.   +6 more
europepmc   +1 more source

The Zoonosis Council: establishing clarity on zoonotic diseases for the general public. [PDF]

Anim Front
Sanders L, Haydon MC, Messman R.
europepmc   +1 more source

The Impact of Health Warnings in e-Cigarette Content on Instagram on Adults' e-Cigarette Cognitions: Online Between-Subjects Experiment Study. [PDF]

J Med Internet Res
Vranken S, Binder A, Matthes J.
europepmc   +1 more source

Social Adaptation: When Software Gives Users a Voice [PDF]

Ali, Raian, Nuseibeh, Bashar, Omoronyia, Inah, Salehie, Mazeiar, Solis, Carlos   +4 more
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