Results 51 to 60 of about 30,588 (184)

DNA Nanostructure‐Templated Multivalency Enables Broad‐Spectrum Virus Inhibition

Advanced Science, EarlyView.
A honeycomb‐shaped DNA nanostructure is introduced that organizes nanobodies or aptamers into trimeric clusters mirroring the native hemagglutinin arrangement on influenza viruses. This geometry‐matched multivalency enhances binding avidity by up to 1000‐fold, resulting in robust, broad‐spectrum viral neutralization and a 30–55% improvement in host ...
Saurabh Umrao, Abhisek Dwivedy, Dhanush Gandavadi, Chi Chen, Lifeng Zhou, Jinwei Duan, Vineetha Mareddy, Ying Fang, Xing Wang   +8 more
wiley   +1 more source

Direct Detection of Viruses Using Antibody‐Modified Gold Nanorods

Journal of Biophotonics, EarlyView.
Gold nanorods functionalized with pathogen‐specific antibodies can be used for the confirmatory detection of viruses via dynamic light scattering–based analysis of particle sizes. ABSTRACT Seasonal and sporadic viral infections put enormous burdens on global health and society. Although polymerase chain reaction (PCR) and other molecular approaches can
Axell Rodriguez, Yana Purvinsh, Aidan P. Holman, Dmitry Kurouski   +3 more
wiley   +1 more source

Immune protection induced on day 10 following administration of the 2009 A/H1N1 pandemic influenza vaccine. [PDF]

PLoS ONE, 2010
The 2009 swine-origin influenza virus (S-OIV) H1N1 pandemic has caused more than 18,000 deaths worldwide. Vaccines against the 2009 A/H1N1 influenza virus are useful for preventing infection and controlling the pandemic.
Yizhuo Sun, Chao Bian, Ke Xu, Weibin Hu, Tongyan Wang, Jun Cui, Hongqiang Wu, Zhiyang Ling, Yongyong Ji, Guomei Lin, Lin Tian, Yanyan Zhou, Bingnan Li, Guiyu Hu, Ning Yu, Wenqi An, Ruowen Pan, Paul Zhou, Qibin Leng, Zhong Huang, Xiaowei Ma, Bing Sun   +21 more
doaj   +1 more source

Natural Reassortment of Eurasian Avian-Like Swine H1N1 and Avian H9N2 Influenza Viruses in Pigs, China

Emerging Infectious Diseases, 2022
Several zoonotic influenza A viruses detected in humans contain genes derived from avian H9N2 subtypes. We uncovered a Eurasian avian-like H1N1 swine influenza virus with polymerase basic 1 and matrix gene segments derived from the H9N2 subtype ...
Wanying Sun, Samuel S.M. Cheng, Kristy N.T. Lam, Tsz C. Kwan, Ricky W.K. Wong, Leo H.K. Lau, Gigi Y.Z. Liu, Leo L.H. Luk, John K.C. Li, Haogao Gu, Malik Peiris, Leo L.M. Poon   +11 more
doaj   +1 more source

Effectiveness of Monovalent 2009 Pandemic Influenza A Virus Subtype H1N1 and 2010–2011 Trivalent Inactivated Influenza Vaccines in Wisconsin During the 2010–2011 Influenza Season [PDF]

The Journal of Infectious Diseases, 2013
The 2009 influenza A virus subtype H1N1 (A[H1N1]pdm09) did not exhibit antigenic drift during the 2010-2011 influenza season, providing an opportunity to investigate the duration of protection after vaccination. We estimated the independent effects of 2010-2011 seasonal trivalent inactivated influenza vaccine (TIV) and A(H1N1)pdm09 vaccine for ...
Allen C, Bateman, Burney A, Kieke, Stephanie A, Irving, Jennifer K, Meece, David K, Shay, Edward A, Belongia   +5 more
openaire   +2 more sources

Identification of Clinical Factors Associated With the Immunogenicity of Homologous ChAdOx1‐nCoV‐19 Vaccine in Hemodialysis Patients

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Hemodialysis (HD) patients are at higher risk of severe COVID‐19 and may exhibit suboptimal vaccine responses. This study evaluates the factors influencing vaccine‐induced immunity in HD patients following the second dose of the Vaxzevria. A total of 276 HD patients and 126 controls were included. Antibody responses were assessed using binding
Chia‐Wei Chang, Ping‐Hsun Wu, Li‐Yun Chang, Yu‐Ying Huang, Teng‐Hui Huang, Su‐Chu Lee, Yi‐wen Chiu, Shang‐Jyh Hwang, Tsun‐Yung Kuo, Mei‐Chuan Kuo   +9 more
wiley   +1 more source

Ratiometric Fluorescence Determination of Avian Influenza a Virus Subtype H1N1 DNA with Functionalized Quantum Dots and Gold Nanoparticles

Analytical Letters, 2022
A new type of ratiometric fluorescence sensor based on DNA functionalized quantum dots (DNA-QDs) and gold nanoparticles (AuNPs) was constructed for sensitive fluorescence determination of the avian influenza A virus subtype H1N1 DNA. Using the nucleic acid strand displacement reaction, the carboxyfluorescein-DNA (FAM-DNA) replaced DNA-QDs on the ...
Ke, Wenmin, Lai, Qizhen, Yang, Yixia, Qian, Jingjing, Ji, Xinghu, He, Zhike   +5 more
openaire   +1 more source

Interaction analysis of non‐bacterial respiratory pathogens during and after the coronavirus disease 2019 pandemic in two cities along the eastern coast of China

Pediatric Investigation, EarlyView.
What is Known • Co‐infections can influence pathogen replication, disease severity, and the duration of illness. • Co‐infection patterns and temporal correlations have been characterized among various respiratory viruses and atypical pathogens. What is New • A consistent negative correlation between influenza B and Mycoplasma pneumoniae suggests ...
Wanxian Ye, Jishan Zheng, Yungang Yang, Xinyue Song, Xiang Yuan, Lan Yang, Jian Yu, Hailin Zhang, Shunhang Wen   +8 more
wiley   +1 more source

In Vitro and In Vivo Antiviral Activity of Nylidrin by Targeting the Hemagglutinin 2-Mediated Membrane Fusion of Influenza A Virus

Viruses, 2020
Influenza A virus, one of the major human respiratory pathogens, is responsible for annual seasonal endemics and unpredictable periodic pandemics. Despite the clinical availability of vaccines and antivirals, the antigenic diversity and drug resistance ...
Yejin Jang, Jin Soo Shin, Joo-Youn Lee, Heegwon Shin, Sang Jick Kim, Meehyein Kim   +5 more
doaj   +1 more source

Deciphering the Heterogeneity of Pulmonary Macrophages in Response to Fine Particles

Small, EarlyView.
This study introduces a dual‐labeled gold nanoparticle model to capture particle–responsive cells via integrating fluorescence‐activated cell sorting and single‐cell RNA sequencing. Fourteen macrophage subsets are identified with response and function heterogeneity, among which AMs_3, AMs_7, and recMacs_4 subsets show stronger phagocytic activation ...
Qing'e Shan, Zheng Dong, Ning Li, Zijie Zhou, Jiayu Ren, Wei Liu, Feng Xu, Yu Qi, Juan Ma, Yi Liu, Shuping Zhang, Sijin Liu   +11 more
wiley   +1 more source