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Introduction: Influenza is a highly contagious respiratory viral illness that is vaccine-preventable and occurs seasonally. While most cases present with mild respiratory symptoms, influenza can lead to severe complications in vulnerable ...
Fatema Ali Mohamed Alekri+1 more
doaj +1 more source
The Quest for a Truly Universal Influenza Vaccine
There is an unmet public health need for a universal influenza vaccine (UIV) to provide broad and durable protection from influenza virus infections. The identification of broadly protective antibodies and cross-reactive T cells directed to influenza ...
Y. Jang, B. Seong
semanticscholar +1 more source
Extracellular matrix remodeling is crucial in cancer progression. Using a peptide to probe the tension of ECM fibers, it was found that Fibronectin fibers gradually lose tension as human breast carcinoma progresses, while their tension is maintained in ductal carcinoma in situ (DCIS), the non‐invasive precursor of breast cancer. This loss of tension is
Arnaud Miéville+6 more
wiley +1 more source
Universal influenza vaccines: from viruses to nanoparticles
Introduction: The current seasonal influenza vaccine confers only limited protection due to waning antibodies or the antigenic shift and drift of major influenza surface antigens. A universal influenza vaccine which induces broad cross-protection against
Ye Wang+3 more
doaj +1 more source
Influenza vaccine: a travelers’ vaccine?
Seasonal influenza affects 5-15% of the world's population annually and is considered to be the second most frequent vaccine-preventable infection in travelers. Despite increasing travel volume worldwide, guidelines on influenza vaccination for international travel are scarce.
Marti, F+2 more
openaire +4 more sources
Chasing Seasonal Influenza - The Need for a Universal Influenza Vaccine.
Chasing Seasonal Influenza As we prepare for a potentially severe influenza season, we must consider whether our current vaccines can be improved and whether longer-term, transformative vaccine approaches are needed to minimize influenza-related ...
Catharine I. Paules+3 more
semanticscholar +1 more source
Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu+13 more
wiley +1 more source
Novel Platforms for the Development of a Universal Influenza Vaccine
Despite advancements in immunotherapeutic approaches, influenza continues to cause severe illness, particularly among immunocompromised individuals, young children, and elderly adults.
A. Kumar, T. Meldgaard, S. Bertholet
semanticscholar +1 more source
Tumor‐Associated Glycan Exploits Adenosine Receptor 2A Signaling to Facilitate Immune Evasion
This study identifies Globo H ceramide (GHCer) as a novel immune checkpoint molecule that suppresses the activation of conventional T lymphocytes while promoting the differentiation and function of regulatory T cells. The immunosuppressive effects of GHCer are mediated through the activation of the A2AR/cAMP/PKA pathway, which involves its interactions
Jing‐Yan Cheng+13 more
wiley +1 more source
A Review of the 2016-2017 Flu Season: Guidelines, Costs, and Barriers
In the United States (US), about 50,000 influenza-related deaths occur annually (Centers for Medicaid and Medicare Services [CMS], 2014). The most important preventive measure for the influenza virus is for people to obtain the influenza vaccine (Varsha
Simone Chinnis+4 more
doaj +1 more source