Results 111 to 120 of about 968,734 (398)

Development of Universal Influenza Vaccines Targeting Conserved Viral Proteins

Vaccines, 2019
Vaccination is still the most efficient way to prevent an infection with influenza viruses. Nevertheless, existing commercial vaccines face serious limitations such as availability during epidemic outbreaks and their efficacy. Existing seasonal influenza
S. D. Jazayeri, C. Poh
semanticscholar   +1 more source

Body Biofluids for Minimally‐Invasive Diagnostics: Insights, Challenges, Emerging Technologies, and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Recent advances in diagnostics have accelerated the development of miniaturized wearable technologies for the continuous monitoring of diseases. This paradigm is shifting healthcare away from invasive, centralized blood tests toward decentralized monitoring, using alternative body biofluids.
Lanka Tata Rao, Chandan Kumar Mandal, Fernando Patolsky   +2 more
wiley   +1 more source

Nonreplicating Influenza A Virus Vaccines Confer Broad Protection against Lethal Challenge

mBio, 2015
New vaccine technologies are being investigated for their ability to elicit broadly cross-protective immunity against a range of influenza viruses. We compared the efficacies of two intranasally delivered nonreplicating influenza virus vaccines (H1 and ...
Mariana Baz, Kobporn Boonnak, Myeisha Paskel, Celia Santos, Timothy Powell, Alain Townsend, Kanta Subbarao   +6 more
doaj   +1 more source

Transient humoral protection against H5N1 challenge after seasonal influenza vaccination of humans. [PDF]

PLoS ONE, 2014
Current influenza vaccines are believed to confer protection against a narrow range of virus strains. The identification of broadly influenza neutralizing antibodies (bnAbs) has triggered efforts to develop vaccines providing 'universal' protection ...
Ramon Roozendaal, Jeroen Tolboom, Anna Roos, Sarra Riahi, Jessica Theeuwsen, Miriam V Bujny, Vincent Klaren, Hans J W M Korse, Liesbeth Dekking, Arijan Grootenhuis, Gerrit Jan Weverling, Wouter Koudstaal, Jaap Goudsmit, Katarina Radošević   +13 more
doaj   +1 more source

M2e-based universal influenza vaccines: a historical overview and new approaches to development

Journal of Biomedical Sciences, 2019
The influenza A virus was isolated for the first time in 1931, and the first attempts to develop a vaccine against the virus began soon afterwards. In addition to causing seasonal epidemics, influenza viruses can cause pandemics at random intervals ...
D. Mezhenskaya, I. Isakova-Sivak, L. Rudenko   +2 more
semanticscholar   +1 more source

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, EarlyView.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

The averted costs due to influenza vaccination with trivalent and quadrivalent vaccines

Журнал инфектологии, 2017
Now WHO experts annually formulates references on structure of both the 3rd, and 4 valent vaccines against influenza applied worldwide.The purpose of work was the assessment of averted costs due to influenza vaccination with trivalent and quadrivalent ...
S. M. Kharit, A. M. Rudakova, A. N. Uskov, L. N. Konovalova, Yu. V. Lobzin   +4 more
doaj   +1 more source

Prevention and Control of Seasonal Influenza with Vaccines: Recommendations of the Advisory Committee on Immunization Practices — United States, 2019–20 Influenza Season

MMWR Recommendations and Reports, 2019
Summary This report updates the 2018–19 recommendations of the Advisory Committee on Immunization Practices (ACIP) regarding the use of seasonal influenza vaccines in the United States (MMWR Recomm Rep 2018;67[No. RR-3]).
L. Grohskopf, E. Alyanak, K. Broder, E. Walter, A. Fry, D. Jernigan   +5 more
semanticscholar   +1 more source

Risk of Guillain-Barré syndrome after 2010–2011 influenza vaccination [PDF]

, 2013
Influenza vaccination has been implicated in Guillain Barré Syndrome (GBS) although the evidence for this link is controversial. A case–control study was conducted between October 2010 and May 2011 in seven Italian Regions to explore the relation between
Beghi, E, Benedetti, M D, Chiò, A, D'Alessandro, R, Filippini, G, Galeotti, F, Granieri, E, Itang, study group., Logroscino, G, Massari, M, Pugliatti, M, Raschetti, R, Santuccio, C   +12 more
core   +1 more source

Automated Label‐Free Assay for Viral Detection and Inhibitor Screening via Biomembrane‐Functionalized Microelectrode Arrays

Advanced Materials, EarlyView.
A bioelectronic sensor integrating 2D cell membranes with organic microelectrode arrays enables detection of SARS‐CoV‐2 fusion pathways. Natively‐expressed viral receptors promote monitoring of viral entry and screening of antibody‐based inhibitors.
Zixuan Lu, Jeremy Treiber, Konstantinos Kallitsis, Ekaterina Selivanovitch, Alexandra Wheeler, Maria Lopez‐Cavestany, Zhongmou Chao, Sarah L Barron, Ju An Park, Darius Hoven, Anna Scheeder, Aimee Withers, Becky M. Hess, Clemens F. Kaminski, Alberto Salleo, Anna‐Maria Pappa, Susan Daniel, Róisín M Owens   +17 more
wiley   +1 more source