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Adjuvantation of Influenza Vaccines to Induce Cross-Protective Immunity
Vaccines, 2021 Influenza poses a huge threat to global public health. Influenza vaccines are the most effective and cost-effective means to control influenza. Current influenza vaccines mainly induce neutralizing antibodies against highly variable globular head of ...
Zhuofan Li +3 more
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The post-2009 influenza pandemic era : time to revisit antibody immunodominance [PDF]
, 2018 The current inactivated influenza vaccines rely on the induction of neutralizing antibodies against the head domain of the viral hemagglutinin (HA). The HA head contains five immunodominant antigenic sites, all of which are subject to antigenic drift ...
Caton +6 more
core +1 more source
Vaccines, 2018 Vaccination against influenza is the most effective approach for reducing influenza morbidity and mortality. However, influenza vaccines are unique among all licensed vaccines as they are updated and administered annually to antigenically match the ...
Surender Khurana
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Heterologous prime-boost vaccination with H3N2 influenza viruses of swine favors cross-clade antibody responses and protection [PDF]
, 2017 The emergence of multiple novel lineages of H1 and H3 influenza A viruses in swine has confounded control by inactivated vaccines. Because of substantial genetic and geographic heterogeneity among circulating swine influenza viruses, one vaccine strain ...
Claes, Gerwin +8 more
core +2 more sources
Cell culture-derived flu vaccine: Present and future
Human Vaccines & Immunotherapeutics, 2018 The benefit of influenza vaccines is difficult to estimate due to the complexity of accurately assessing the burden of influenza. To improve the efficacy of influenza vaccines, vaccine manufacturers have developed quadrivalent influenza vaccine (QIV ...
Alberto Pérez Rubio, Jose María Eiros
doaj +1 more source
Projected impact of a plant-derived vaccine on the burden of seasonal influenza in Canada
Human Vaccines & Immunotherapeutics, 2021 Objective The analysis estimates projected population outcomes resulting from the introduction of a plant-derived influenza vaccine formulated as quadrivalent virus-like particles (QVLP) in Canada.
Lauren Ramjee +7 more
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Virus-Vectored Influenza Virus Vaccines
Viruses, 2014 Despite the availability of an inactivated vaccine that has been licensed for >50 years, the influenza virus continues to cause morbidity and mortality worldwide.
Ralph A. Tripp, S. Mark Tompkins
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Construction and characterization of H5N1-recombinant fowlpox viruses co-expressing host cytokines [PDF]
, 2011 Possessing a large double stranded DNA genome up to 300 kb, fowlpox virus (FWPV) has been developed to express avian influenza virus (AIV) antigens since the late 1980s. A more advanced approach would be to coexpress host cytokines from such recombinants.
Abdul Razak, Mariatulqabtiah +1 more
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Relapse of polymyalgia rheumatica following adjuvanted influenza vaccine: A case-based review [PDF]
, 2020 Polymyalgia rheumatica (PMR) is the most common inflammatory rheumatological condition affecting individuals aged >50 years. There have been rare reports of PMR and other vasculitides developing within 3 months of influenza vaccination.
Bassendine, Margaret F., Bridge, Simon
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Adjuvanted influenza vaccines [PDF]
Human Vaccines & Immunotherapeutics, 2012 The search for adjuvants has been stimulated by the need to ensure greater protection against influenza among subjects who show a reduced immune response to conventional influenza vaccines. Aluminum salts have long been used but are not considered satisfactory.
N. Principi +1 more
openaire +7 more sources