Results 31 to 40 of about 2,815,929 (298)

Abductive retrieval for multimedia information seeking [PDF]

open access: yes, 2003
In this paper we discuss an approach to the retrieval of data annotated using the MPEG-7 multimedia description schema. In particular we describe a framework for the retrieval of annotated video samples that is based on principles from the area of ...
Lalmas, Mounia   +2 more
core   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

User Intent Prediction in Information-seeking Conversations

open access: yes, 2019
Conversational assistants are being progressively adopted by the general population. However, they are not capable of handling complicated information-seeking tasks that involve multiple turns of information exchange.
Bhatia S.   +15 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Workshop on web information seeking and interaction [PDF]

open access: yes, 2007
The World Wide Web has provided access to a diverse range of information sources and systems. People engaging with this rich network of information may need to interact with different technologies, interfaces, and information providers in the course of a
Rodden, K., Ruthven, I., White, R. W.
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Medical information seeking behavior of urban patients in Zhejiang Province, China: a cross-sectional study

open access: yesBMC Public Health, 2022
Background Health information seeking behavior (HISB) is a prevalent research topic. However, little is known about sociodemographic factors of HISB in China.
Liyun Liu
doaj   +1 more source

Leveraging Social Foci for Information Seeking in Social Media [PDF]

open access: yes, 2015
The rise of social media provides a great opportunity for people to reach out to their social connections to satisfy their information needs. However, generic social media platforms are not explicitly designed to assist information seeking of users.
Hu, Xia   +4 more
core   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

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