Results 51 to 60 of about 500,597 (217)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Information Seeking Behaviours of Historians
Türk Kütüphaneciliği, 2013 Among user studies, which date to the 1940s, historians have become subject of various research since the 1970s. In this paper, historians’ information seeking behaviour is analyzed in terms of information sources, information channels, information ...
Hatice Gülşen Birinci
doaj
AIB Studi, 2020 L’articolo si propone di approfondire le peculiarità della relazione tra i lettori dell’era contemporanea e la massa di stimoli comunicativi caratterizzante un panorama documentario in continua ed esponenziale crescita: proprio per descrivere la ...
Roberto Musiari
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Information seeking by Pakistani farmers
Pakistan Journal of Information Management & Libraries, 2012 The purpose of this article is to provide a critical review of published research on information seeking by Pakistani farmers, with a view to inform the relevant departments and individuals of the existing situation.
Muhammad Asif Naveed +2 more
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FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
Smart Tools for Academic Information Seeking
Nordic Journal of Information Literacy in Higher Education, 2016 Systematic information seeking is an essential part of academic work. Research and information seeking go hand in hand, and both need planning. In the academic world you can hardly avoid the research plan, but you probably won’t hear that much about the ...
Eeva Koponen, Tiia Puputti
doaj +1 more source