Results 51 to 60 of about 17,096,963 (292)
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Information Need and Information Seeking Behaviour
Türk Kütüphaneciliği, 1997 Information need is one of the cognitive needs of humankind. Information need causes information seeking behaviour and these concepts complement each other. Information need and information seeking behaviour are effected by many factors.
Nazan Özenç Uçak
doaj
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Shifts Between Search Stages During Task-performance in Mediated Information Seeking Interaction [PDF]
, 2005 The research reported here focuses on the users' information seeking behavior. Set in the framework of the interactive information retrieval paradigm, the research examines the micro-dynamics of the information seeking process, and explores search stages
Olah, Judit
core +1 more source
Information Research: An International Electronic Journal, 2004 The intention of this paper is to look at how the World Wide Web is used in looking for information in the domain of personal development. The theoretical aim of the paper is to elaborate conceptual tools for understanding better the content of Web pages,
Jarkko Kari
doaj
What is the information Seeking and Behavior of Information Seeking?
, 2004 Whatever population and using computerized systems in home, Official and receptive dimensions is increasing, whatever digital data is increasing and then searching of users is increasing too. Surely users have problems, Like: Selecting information sources that dont answer to informational needs, disability to specification available facilities in ...
openaire +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
A process Approach to Information Services: Information Search Process (ISP) Model
Iranian Journal of Information Processing & Management, 2010 Information seeking is a behavior emerging out of the interaction between information seeker and information system and should be regarded as an episodic process so as to meet information needs of users and to take different roles in different stages of ...
Hamid Keshavarz, Abaas Eslami
doaj
Horse owners seeking online health information: a mixed-methods study
Frontiers in Veterinary ScienceBackgroundMany people seek health-related information online, not only for themselves but also on behalf of others who cannot articulate their symptoms.
Laura Haase +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source