Results 61 to 70 of about 500,597 (217)
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Towards collaboration between information seeking and information retrieval
Information Research: An International Electronic Journal, 2005 Introduction. The conceptual framework of librarianship and information science has developed rapidly over the past decade with the prospect of application in other fields.
Carol C. Kuhlthau
doaj
FEBS Open Bio, EarlyView.A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo +7 more
wiley +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
A neural network for information seeking
Nature Communications, 2019 Animals resolve uncertainty by seeking knowledge about the future. How the brain controls this is unclear. The authors show that a network including primate anterior cingulate cortex and basal ganglia encodes opportunities to gain information about ...
J. Kael White +6 more
doaj +1 more source
FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source
Information Research: An International Electronic Journal, 2005 [Introduction. We explored Harris and Dewdney's principle that people follow habitual patterns when seeking everyday information along with Pettigrew's notion of information grounds. [Method.
Fisher Naumer +3 more
doaj
Information Seeking Barriers in School Libraries and Review of Approaches [PDF]
تحقیقات اطلاعرسانی و کتابخانههای عمومی, 2008 The basic mission of education is the mental and spiritual elevation of students. As an Institution it should prepare students for critical thinking. Thus the most important role of a school library is aimed to teach information literacy.
doaj
Compulsory voting and voter information seeking
Research & Politics, 2018 Compulsory voting is known to produce a relatively weak match between voters’ ballot choices and their preferences. We theorize that this link, in part, exists because compelled voters are relatively unlikely to seek out political information during an ...
Shane P. Singh, Jason Roy
doaj +1 more source
FEBS Open Bio, EarlyView.KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura +19 more
wiley +1 more source