Results 51 to 60 of about 11,365,722 (324)

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Students' Information Sources and Information-Seeking Challenges:

International Journal of Librarianship
Academic libraries play a pivotal role in developing strategies to improve access to information, promote literacy, and offer support to students, particularly during unexpected events such as the pandemic.
Camia Lasig, Nuelah Reyes, Roselyn Madia, Richie Garabiles, Vanessa Morales   +4 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Online Health Information Seeking Among US Adults: Measuring Progress Toward a Healthy People 2020 Objective

Public health reports (1974), 2019
Objective: During the past decade, the availability of health information online has increased dramatically. We assessed progress toward the Healthy People 2020 (HP2020) health communication and health information technology objective of increasing the ...
L. F. Finney Rutten, Kelly D. Blake, Alexandra J. Greenberg-Worisek, S. Allen, R. Moser, B. Hesse   +5 more
semanticscholar   +1 more source

Analyzing and Characterizing User Intent in Information-seeking Conversations [PDF]

Annual International ACM SIGIR Conference on Research and Development in Information Retrieval, 2018
Understanding and characterizing how people interact in information-seeking conversations is crucial in developing conversational search systems. In this paper, we introduce a new dataset designed for this purpose and use it to analyze information ...
Chen Qu, Liu Yang, W. Bruce Croft, Johanne R. Trippas, Yongfeng Zhang, Minghui Qiu   +5 more
semanticscholar   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Response Ranking with Deep Matching Networks and External Knowledge in Information-seeking Conversation Systems [PDF]

Annual International ACM SIGIR Conference on Research and Development in Information Retrieval, 2018
Intelligent personal assistant systems with either text-based or voice-based conversational interfaces are becoming increasingly popular around the world.
Liu Yang, Minghui Qiu, Chen Qu, J. Guo, Yongfeng Zhang, W. Bruce Croft, Jun Huang, Haiqing Chen   +7 more
semanticscholar   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Information Need and Information Seeking Behaviour

Türk Kütüphaneciliği, 1997
Information need is one of the cognitive needs of humankind. Information need causes information seeking behaviour and these concepts complement each other. Information need and information seeking behaviour are effected by many factors.
Nazan Özenç Uçak
doaj  

Horse owners seeking online health information: a mixed-methods study

Frontiers in Veterinary Science
BackgroundMany people seek health-related information online, not only for themselves but also on behalf of others who cannot articulate their symptoms.
Laura Haase, Laura Haase, Julia Winter, Sophia Grummt, Martin Sedlmayr, Brita Sedlmayr   +5 more
doaj   +1 more source