Results 81 to 90 of about 4,635,546 (299)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Numerical simulation of two-phase filtration in the near well bore zone
Open Engineering, 2018 On the basis of the fundamental laws of energy conservation, nonstationary processes of filtration of two-phase liquids in multilayered reservoirs in the near well bore zone are considered.
Maksat Kalimoldayev +4 more
doaj +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Fractal representations in image processing of remote sensing of the earth [PDF]
E3S Web of ConferencesThis article explores the application of fractal representations in the image processing of remote sensing data for Earth observation. Fractals, with their self-similar properties and complex patterns, offer a powerful mathematical framework for ...
Khudaiberdiev Mizaakbar +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
High-Performance Annotation Tagging over Solr Full-text Indexes
Information Technology and Libraries, 2014 In this work, we focus on the problem of “annotation tagging” over Information Spaces of objects stored in a full-text index. In such a scenario, tags are assigned to objects by “data curator” users with the purpose of classification, while generic end ...
Paolo Manghi +5 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
The JINR Tier1 Site Simulation for Research and Development Purposes
EPJ Web of Conferences, 2016 Distributed complex computing systems for data storage and processing are in common use in the majority of modern scientific centers. The design of such systems is usually based on recommendations obtained via a preliminary simulated model used and ...
Korenkov V. +6 more
doaj +1 more source
Information culture and information technologies as related to the health care [PDF]
, 2013 There many factors affecting people’s health nowadays, so the problem of health care is of multiple-aspect one. Stress and hypodynamia are considered to be the seat of the trouble.
Nesterova, O.Yu.
core
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source