Results 81 to 90 of about 4,612,999 (280)
The JINR Tier1 Site Simulation for Research and Development Purposes
EPJ Web of Conferences, 2016 Distributed complex computing systems for data storage and processing are in common use in the majority of modern scientific centers. The design of such systems is usually based on recommendations obtained via a preliminary simulated model used and ...
Korenkov V. +6 more
doaj +1 more source
Fractal representations in image processing of remote sensing of the earth [PDF]
E3S Web of ConferencesThis article explores the application of fractal representations in the image processing of remote sensing data for Earth observation. Fractals, with their self-similar properties and complex patterns, offer a powerful mathematical framework for ...
Khudaiberdiev Mizaakbar +3 more
doaj +1 more source
The economics of Information Technologies Standards & [PDF]
This research investigates the problem of Information Technologies Standards or Recommendations from an economical point of view. In our competitive economy, most enterprises adopted standardization’s processes, following recommendations of specialized ...
Eric Thivant, Laid Bouzidi
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Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
International Journal of Serious Games, 2019 This study evaluates user acceptance of a gamification-enabled collaboration and knowledge sharing platform that has been developed for use by personnel in industrial work environments, aiming at increasing motivation for knowledge exchange. The platform
Stylianos Zikos +5 more
doaj +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Editorial: Applications of geospatial information technologies and spatial statistics in health services research. [PDF]
Front Public Health, 2023 Song C, Wang X, Ge E, Shi X, Pan J.
europepmc +1 more source
Information technologies for the information agent [PDF]
, 2007 The information agent has requirements in the Information Technology (IT) age that are in everything comparable to those of one hundred years ago.
Magalhães, Paulo Sérgio Tenreiro +4 more
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