Results 161 to 170 of about 539,277 (324)

Optimizing phenobarbital dosing in critically ill patients with refractory and superrefractory status epilepticus using a population pharmacokinetic model

Epilepsia, EarlyView.
Abstract Objective Current weight‐based dosing fails to account for pharmacokinetic variability in refractory and superrefractory status epilepticus (RSE, SRSE). However, understanding pharmacokinetics in critically ill patients with varying degrees of organ dysfunction can improve both safety and efficacy.
Maximilian Stoschus, Moritz L. Schmidbauer, Johannes Starp, Stefan Kunst, Georgios Gakis, Michael Paal, Michael Vogeser, Christina Scharf‐Janssen, Uwe Liebchen, Konstantinos Dimitriadis   +9 more
wiley   +1 more source

Comprehensive Literature Review Evaluating the Use, Safety, and Efficacy of Subcutaneous Methotrexate in the Treatment of Adult Patients With Moderate‐To‐Severe Plaque‐Type Psoriasis

International Journal of Dermatology, EarlyView.
ABSTRACT Methotrexate (MTX) is a conventional systemic therapy widely used to treat chronic plaque‐type psoriasis, a chronic inflammatory skin disease that significantly impacts patients' quality of life. MTX can be administered orally or subcutaneously. Over the past decades, the use of subcutaneous versus oral MTX has been a subject of ongoing debate
Manuelle Viguier, José‐Manuel Carrascosa‐Carrillo, Pariyawan Rakvit, Maria‐Magdalena Constantin, Alice‐Anaïs Varlet, Solenn Le Clanche, Linda A. W. Verhagen, Wolf‐Henning Boehncke   +7 more
wiley   +1 more source

Estudio aleatorio de dos emulsiones grasas diferentes en la nutrición parenteral total del enfermo quirúrgico desnutrido: efecto sobre la morbilidad infecciosa y la mortalidad Randomized study of two different fat emulsions in total parenteral nutrition of malnourished surgical patients: effect on infectious morbidity and mortality

Nutrición Hospitalaria, 2003
Objetivo: Las infusiones lipídicas de una mezcla física de triglicéridos de cadena media/triglicéridos de cadena larga (MCT/LCT), utilizadas en la nutrición parenteral total (NPT) peroperatoria, tienen menos efecto inmunosupresor en estudios de ...
T. Grau, J. Carlos Ruiz de Adana, S. Zubillaga, S. Fuerte, C. Girón   +4 more
doaj  

Formulation Development of Parenteral Phospholipid-based Microemulsion of Etoposide

AAPS PharmSciTech, 2010
Jayesh M Jain, C. Fernandes, V. Patravale   +2 more
semanticscholar   +1 more source

Flagellins as Vaccine Adjuvants and Cancer Immunotherapy: Recent Advances and Future Prospects

Immunology, EarlyView.
The figure depicts the role of flagellin in immune cells. Flagellin interacts with TLR5, resulting in the formation of homodimers and the recruitment of MyD88, which activates the IκB and MAPK signalling pathways. This results in the activation of NF‐κB and AP‐1, producing TNF‐α, IL‐6, IL‐8, and IL‐12.
Asma Talukder, Md. Mijanur Rahman, Md. Sifat Rahi, Dean L. Pountney, Ming Q. Wei   +4 more
wiley   +1 more source

Tratamiento dietético-nutricional en la enteritis rádica crónica: A propósito de un caso clínico complejo Dietetic-nutritional treatment in chronic radiation enteritis: Apropos of a complex clinical case

Nutrición Hospitalaria, 2003
Presentamos un caso clínico de enteritis rádica crónica seguido durante 34 meses, cuyas características destacables son las siguientes: Paciente de 60 años con adenocarcinoma de recto que requirió hemicolectomia izquierda (Hartmann), recibiendo ...
A. Fernández de Bustos, A. M.ª Pita Mercé   +1 more
doaj  

Determinants of the optimal selection of vascular access devices: A systematic review underpinned by the COM‐B behavioural model

Journal of Advanced Nursing, EarlyView.
Abstract Background Optimal selection of vascular access devices is based on multiple factors and is the first strategy to reduce vascular access device‐related complications. This process is dependent on behavioural and human factors. The COM‐B (Capability, Opportunity, Motivation, Behaviour) model was used as a theoretical framework to organize the ...
Ismael Fernández‐Fernández, Enrique Castro‐Sánchez, Ian Blanco‐Mavillard   +2 more
wiley   +1 more source

Implementation frameworks, strategies and outcomes in optimizing central venous access device practice in paediatrics: A scoping review

Journal of Advanced Nursing, EarlyView.
Abstract Paediatric patients with complex or acute conditions may require a central venous access device, however, almost one‐third of these devices have associated complications (e.g. infections). Implementation of evidence‐based practices regarding central venous access devices can reduce and potentially prevent complications.
Elouise R. Comber, Samantha Keogh, Linda N. Nguyen, Joshua Byrnes, Amanda J. Ullman   +4 more
wiley   +1 more source

Implementation contexts and strategies for alternative peripherally inserted central catheter material and design selection: A qualitative exploration using CFIR/ERIC approach

Journal of Advanced Nursing, EarlyView.
Abstract Aim To explore the implementation contexts and strategies that influence the uptake and selection of alternative peripherally inserted central catheter (PICC) materials and design. Design Qualitative evaluation of end user perspectives within a randomized control trial of different PICC materials and design.
Deanne August, Rachel M. Walker, Victoria Gibson, Nicole Marsh, Tricia M. Kleidon, Alana Delaforce, Claire Mihalopoulous, Amanda Ullman, Samantha Keogh   +8 more
wiley   +1 more source

Prehabilitation Interventions in Patients Undergoing Colorectal Cancer Surgery: A Systematic Review and Meta‐Analysis

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Surgical resection is the primary treatment modality for colorectal cancer. Prehabilitation is about enhancing the patient's physiological capacity preoperatively to reduce the risk of treatment‐related complications. Clear definitions of the modality, content, and duration of prehabilitation, including its components such as ...
Yi‐Shu Liao, Hsiao‐Yean Chiu, Fu‐Huan Huang, Yu‐Han Chang, Yu‐Min Huang, Po‐Li Wei, Weu Wang, Chin‐Sheng Hung, Heng‐Hsin Tung   +8 more
wiley   +1 more source