Results 71 to 80 of about 543,288 (335)

Pharmaceutical hemostasis at peptic ulcer bleeding: state-of-the-art and perspectives

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2013
Aim of investigation. To study efficacy of parenteral proton pump inhibitors in patients with ulcerative gastroduodenal bleeding.Material and methods. Overall 71 patients were included in original study.
A. A. Schegolev, O. A. Al Sabunchi, S. A. Valetov, A. V. Pavlychev, Ye. A. Klochneva   +4 more
doaj  

Home parenteral nutrition with an omega-3-fatty-acid-enriched MCT/LCT lipid emulsion in patients with chronic intestinal failure (the HOME study):study protocol for a randomized, controlled, multicenter, international clinical trial [PDF]

, 2019
BACKGROUND: Home parenteral nutrition (HPN) is a life-preserving therapy for patients with chronic intestinal failure (CIF) indicated for patients who cannot achieve their nutritional requirements by enteral intake.
A Van Gossum, A.M. Eltweri, Alastair Forbes, AR Heller, Bernhard Glotzbach, CJ Jones, Cécile Chambrier, DL Burns, E Venecourt-Jackson, EM Tillman, Farooq Rahman, Geert Wanten, GJ Wanten, H Baldermann, Ivan R. Diamond, J Wang, Jacek Sobocki, K Mayer, Kinga Szczepanek, KM Gura, L Pironi, L Pironi, Loris Pironi, M Cavicchi, M Rubin, M Staun, Marek Kunecki, MS Mundi, MS Mundi, MW Wichmann, Nicole Lincke, O Goulet, PB Jeppesen, PT Clayton, RT Hurt, S Klek, S Klek, Sheldon C. Cooper, Simon Gabe, Stanislaw Klek, T Grau-Carmona, W Lehmacher, Z Xu   +42 more
core   +3 more sources

Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application

BMEMat, EarlyView.
The graphical abstract illustrates the diverse nanostructures employed in transdermal drug delivery systems, highlighting their unique mechanisms to penetrate the intricate layers of skin. It provides a detailed representation of the skin's complex anatomy, emphasizing the challenges posed by its barrier properties.
Syed Waqas Ali Shah, Xingxing Li, Hao Yuan, Huiling Shen, Shaohao Quan, Guifang Pan, Muhammad Ishfaq, Abid Ullah Shah, Hanhan Xie, Jundong Shao   +9 more
wiley   +1 more source

Optimizing clarification processes in biopharmaceutical manufacturing through quality by design: Strategies, implications, and future prospects

Biotechnology Progress, EarlyView.
Abstract Biopharmaceutical manufacturing processes in which the product of interest is extracellularly expressed typically employ a clarification step following cell culture or fermentation. During clarification, crude cell culture fluid or fermentation broth is processed to remove insoluble solids, cells, debris, and other particulates, with the ...
Kyeong‐won Yeop, Hyun‐ju Nam, Chang‐jae Shim, So‐mi Yang, Hyo‐won Kim, Cheon Ik Park, Subhasis Banerjee, Yanglin Mok   +7 more
wiley   +1 more source

Micellar Liquid Chromatography Determination of Edoxaban in Oral Solid Dosage Forms: Theoretical Aspects and Validation

ChemMedChem, EarlyView.
A method is developed and validated to quantify edoxaban in solid oral dosage forms using micellar liquid chromatography. A chemometric strategy is used to study the retention mechanism. The procedure is green, economic, safe, and easy to handle; offers high sample throughput; and is reliable, thus useful for pharmaceutical quality control.
Juan Peris‐Vicente, Devasish Bose, Rajendra‐Pasad Pawar, Abhilasha Durgbanshi, Samuel Carda‐Broch   +4 more
wiley   +1 more source

Repurposing Acebutolol for Osteoporosis Treatment: Insights From Multi‐Omics and Multi‐Modal Data Analysis

Clinical Pharmacology &Therapeutics, EarlyView.
Overview of a multi‐omics based drug repurposing strategy. The systematic drug repurposing strategy included the following steps: (1) osteoporosis driver signaling networks were identified from multi‐omics data; (2) drug functional modules were obtained using a network fusion approach to integrate drug similarity information; (3) all drugs were ranked ...
Dan‐Yang Liu, Hui Shen, Jonathan Greenbaum, Qiao‐Rong Yi, Shuang Liang, Yue Zhang, Jia‐Chen Liu, Chuan Qiu, Lan‐Juan Zhao, Qing Tian, Kuan‐Jui Su, Zhe Luo, Li Wu, Xiang‐He Meng, Hong‐Mei Xiao, Yun Deng, Yang Li, Dragana Lovre, Vivian Fonseca, Fernando L. Sanchez, Li‐Jun Tan, Hong‐Wen Deng   +21 more
wiley   +1 more source

Whole-body protein kinetics in critically ill patients during 50 or 100% energy provision by enteral nutrition: A randomized cross-over study.

PLoS ONE, 2020
BackgroundEnteral nutrition (EN) is a ubiquitous intervention in ICU patients but there is uncertainty regarding the optimal dose, timing and importance for patient-centered outcomes during critical illness.
Martin Sundström Rehal, Felix Liebau, Jan Wernerman, Olav Rooyackers   +3 more
doaj   +1 more source

Exogenous Glucose Administration Impairs Glucose Tolerance and Pancreatic Insulin Secretion during Acute Sepsis in Non-Diabetic Mice [PDF]

, 2013
Objectives:The development of hyperglycemia and the use of early parenteral feeding are associated with poor outcomes in critically ill patients. We therefore examined the impact of exogenous glucose administration on the integrated metabolic function of
Adolfo Garcia-Ocana, AO Agwunobi, Baobo Zou, Bryan J. McVerry, Charles C Caldwell, Christopher P. O’Donnell, Darko Stefanovski, DC Angus, DC Frankenfield, FM Brunkhorst, G Van den Berghe, G Van den Berghe, G Vila, JE Ayala, JF Patiño, JG Heuer, JL Berk, JM Naylor, K Maedler, Lanping Guo, Laura C. Alonso, LC Alonso, LC Alonso, ME Woodske, MP Casaer, MR Losser, NS Sauter, PE Marik, R Krogh-Madsen, RN Bergman, S Finfer, S Hagiwara, SJ Finney, Srikanth Singamsetty, VK Mehta, Y Wei, Yoshio Watanabe   +36 more
core   +4 more sources

Danger of co-administration ferric carboxymaltose and denosumab: hypophosphatemia

The Egyptian Journal of Internal Medicine
Both denosumab-induced hypocalcemia and ferric carboxymaltose infusion-related hypophosphatemia have been extensively documented. There are significant risks associated with combining ferric carboxymaltose parenteral infusions and denosumab, including ...
Aysun Seker, Nurdan Senturk Durmus
doaj   +1 more source

Enteral feeding pumps: efficacy, safety, and patient acceptability. [PDF]

, 2014
Enteral feeding is a long established practice across pediatric and adult populations, to enhance nutritional intake and prevent malnutrition. Despite recognition of the importance of nutrition within the modern health agenda, evaluation of the efficacy ...
King, L, White, H
core   +2 more sources