LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Exploring the Chemical Fingerprint and In Vitro Biocompatibility of Wild-Growing and Ex Situ Cultivated Stachys cretica subsp. cretica in the Same Region (Crete, Greece). [PDF]
Tomou EM +6 more
europepmc +1 more source
Postoperative hepatic arterial infusion pump chemotherapy after resection of multinodular colorectal liver metastases [PDF]
Romane Brawermann +7 more
openalex +1 more source
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
OUT–OF–HOSPITAL FLUID INFUSION IN THE SHOCK PATIENT: A SYSTEMATIC REVIEW OF THE LITERATURE [PDF]
Tina L. Palmieri, Daniela Boni, A. Conte
openalex +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Effects of Fentanyl-Adulterated Methamphetamine on Circulating Ghrelin in Rats. [PDF]
Wei H +6 more
europepmc +1 more source

