Results 101 to 110 of about 94,856 (286)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Efficiency of self-healing cementitious materials with encapsulated polyurethane to reduce water ingress through cracks

Materiales de Construccion, 2018
Cracks in reinforced concrete elements can cause major durability issues due do the accelerated ingress of aggressive substances. In this study, repair of cracks was addressed by incorporating encapsulated polyurethane based healing agents in the ...
B. Van Belleghem, K. Van Tittelboom, N. De Belie   +2 more
doaj   +1 more source

Long-term, multiwavelength light curves of ultra-cool dwarfs: II. The evolving light curves of the T2. 5 SIMP 0136 & the uncorrelated light curves of the M9 TVLM 513 [PDF]

, 2016
We present multiwavelength, multi-telescope, ground-based follow-up photometry of the white dwarf WD 1145+017, that has recently been suggested to be orbited by up to six or more, short-period, low- mass, disintegrating planetesimals.
Croll, B., Dalba, P. A., Han, E., Lichtman, J., Muirhead, P. S., Radigan, J.   +5 more
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

SDNsec: Forwarding Accountability for the SDN Data Plane

, 2016
SDN promises to make networks more flexible, programmable, and easier to manage. Inherent security problems in SDN today, however, pose a threat to the promised benefits. First, the network operator lacks tools to proactively ensure that policies will be
Hoefler, Torsten, Lee, Taeho, Pappas, Christos, Perrig, Adrian, Sasaki, Takayuki   +4 more
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Binning is sinning: morphological light-curve distortions due to finite integration time

, 2014
We explore how finite integration times or equivalently temporal binning induces morphological distortions to the transit light-curve. These distortions, if uncorrected for, lead to the retrieval of erroneous system parameters and may even lead to some ...
Agol, Borucki, Borucki, Carter, Carter, Charbonneau, Daemgen, David M. Kipping, Deming, Gilliland, Henry, Holman, Kipping, Kipping, Kipping, Kipping, Kipping, Kipping, Koch, Mandel, McKeeman, O'Donovan, O'Donovan, Seager, Seager, Tinetti, Winn, Winn, Winn   +28 more
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Resource management in IP-based radio access networks [PDF]

, 2001
IP is being considered to be used in the Radio Access Network (RAN) of UMTS. It is of paramount importance to be able to provide good QoS guarantees to real time services in such an IP-based RAN.
El Allali, H., Heijenk, G.
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source