Results 51 to 60 of about 64,020 (238)

Frequency of rpoB, katG, and inhA Gene Polymorphisms Associated with Multidrug-Resistant Mycobacterium tuberculosis Complex Isolates among Ethiopian TB Patients: A Systematic Review

Interdisciplinary Perspectives on Infectious Diseases, 2022
Tuberculosis (TB) is one of the top 10 causes of mortality and the first killer among infectious diseases of poverty (IDoPs) worldwide. It disproportionately affects on-third of the world's low-income countries including Ethiopia.
Aynias Seid, N. Berhane, Semira Nureddin
semanticscholar   +1 more source

A Systematic Approach to Identifying Protein-Ligand Binding Profiles on a Proteome Scale [PDF]

, 2008
Identification of protein-ligand interaction networks on a proteome scale is crucial to address a wide range of biological problems such as correlating molecular functions to physiological processes and designing safe and efficient therapeutics.
Lei Xie, Li Xie, Nancy Buchmeier, Philip Bourne   +3 more
core   +2 more sources

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

Investigations on mutations in katG gene and inhA promoter region associated with isoniazid resistance in the clinical isolates of mycobacterium tuberculosis from Tehran, Iran

Chronic Diseases Journal
BACKGROUND: Isoniazid (INH) is one of the first-line drugs used for the treatment of Mycobacterium tuberculosis (Mtb). This study aimed to determine the mutations in katG and inhA promoter regions associated with INH resistance in clinical isolates of ...
Shahrzad Shafiei, Kambiz Davari, Sabah Hasani   +2 more
doaj   +1 more source

Testis exposure to unopposed/elevated activin A in utero affects somatic and germ cells and alters steroid levels mimicking phthalate exposure

Frontiers in Endocrinology, 2023
Correct fetal testis development underpins adult male fertility, and TGFβ superfamily ligands control key aspects of this process. Transcripts encoding one such ligand, activin A, are upregulated in testes after sex determination and remain high until ...
Penny A. F. Whiley, Penny A. F. Whiley, Michael C. M. Luu, Liza O’Donnell, David J. Handelsman, Kate L. Loveland, Kate L. Loveland   +6 more
doaj   +1 more source

Design, synthesis and computational studies of new azaheterocyclic coumarin derivatives as anti-Mycobacterium tuberculosis agents targeting enoyl acyl carrier protein reductase (InhA)

RSC Advances
In this study, we designed and synthesized a series of coumarin derivatives as antitubercular agents targeting the enoyl acyl carrier protein reductase (InhA) enzyme.
Rasha Z. Batran, Ahmed Sabt, J. Dziadek, A. Kassem   +3 more
semanticscholar   +1 more source

Urea derivatives carrying a thiophenylthiazole moiety: Design, synthesis, and evaluation of antitubercular and InhA inhibitory activities

Drug development research (Print), 2022
The recent emergence of drug‐resistant strains of Mycobacterium tuberculosis (Mtb) has complicated and significantly slowed efforts to eradicate and/or reduce the worldwide incidence of life‐threatening acute and chronic cases of tuberculosis.
Rüveyde Keleş Atıcı, Ş. D. Doğan, M. Gündüz, V. Krishna, Mélina Chebaiki, Håvard Homberset, C. Lherbet, L. Mourey, T. Tønjum   +8 more
semanticscholar   +1 more source

Laser‐Assisted Phase Engineering of 2D MoS2 for Efficient Solution‐Processed Electronics

Advanced Materials, EarlyView.
Here, local laser‐assisted phase transition from solution‐processed phase‐pure 1T′ to 2H MoS2 is shown to critically depend on the irradiation atmosphere. While processing in air leads to damaged insulating regions, inert conditions yield semiconducting 2H domains, enabling direct field‐effect transistor patterning with optimized lateral 1T′‐2H MoS2 ...
Anna Zhuravlova, Minjuan Li, Osamah Alharbi, Yeonsu Jeong, Bin Han, Lei Gao, Mischa Bonn, Mario Lanza, Sheng Yang, Antonio Gaetano Ricciardulli, Paolo Samorì   +10 more
wiley   +1 more source

Discovery of novel and potent InhA inhibitors by an in silico screening and pharmacokinetic prediction.

Future Medicinal Chemistry, 2022
Aim: In silico screening approaches were performed to discover novel InhA inhibitors. Methods: Candidate InhA inhibitors were obtained from the combination of virtual screening and pharmacokinetic prediction.
Chayanin Hanwarinroj, Nareudon Phusi, Bundit Kamsri, Pharit Kamsri, Auradee Punkvang, Sombat Ketrat, P. Saparpakorn, S. Hannongbua, Khomson Suttisintong, P. Kittakoop, J. Spencer, A. Mulholland, P. Pungpo   +12 more
semanticscholar   +1 more source

Vacuum‐Evaporated, Lead‐Free RbYbI3 Perovskite Interlayers for Universal Electron Injection in High‐Performance Organic Light‐Emitting Diodes

Advanced Materials, EarlyView.
ABSTRACT The optoelectronic performance of organic light‐emitting diodes (OLEDs) is critically governed by charge injection from electrodes into organic layers, where significant energy barriers at the interfaces often impede efficient charge injection.
Amarja S. Katware, Woo‐Sam Kim, Jee‐Hun Jang, Hanbeen Lee, Al Amin, Jino Im, Beom‐Soo Kim, Jeong‐Hwan Lee   +7 more
wiley   +1 more source