Results 71 to 80 of about 64,020 (238)

High-level resistance to isoniazid and ethionamide in multidrug-resistant Mycobacterium tuberculosis of the Lisboa family is associated with inhA double mutations [PDF]

, 2017
Objectives The purpose of this study was to determine the levels of isoniazid and ethionamide resistance and to identify associated mutations in endemic multidrug-resistant (MDR) strains of Mycobacterium tuberculosis from the Lisbon metropolitan area ...
Boettger, Erik C., Couto, Isabel, Machado, Diana, Perdigão, João, Portugal, Isabel, Ramos, Jorge, Ritter, Claudia, Viveiros, Miguel   +7 more
core  

Random Matrix Theory and Cross-correlations in Global Financial Indices and Local Stock Market Indices

, 2013
We analyzed cross-correlations between price fluctuations of global financial indices (20 daily stock indices over the world) and local indices (daily indices of 200 companies in the Korean stock market) by using random matrix theory (RMT).
Ha, Gyeong Gyun, Lee, Jae Woo, Maeng, Seong Eun, Nobi, Ashadun   +3 more
core   +1 more source

New InhA Inhibitors Based on Expanded Triclosan and Di-Triclosan Analogues to Develop a New Treatment for Tuberculosis

Pharmaceuticals, 2021
The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) has reinforced the need for the development of new anti-TB drugs. The first line drug isoniazid inhibits InhA. This is a prodrug requiring activation by the
Sarentha Chetty, Tom Armstrong, Shalu Sharma Kharkwal, W. Drewe, Cristina I. De Matteis, D. Evangelopoulos, S. Bhakta, N. R. Thomas   +7 more
semanticscholar   +1 more source

Exploring the Impact of RNU4‐2 Defects on Neurodevelopmental Disorders in a Korean Population

Clinical Genetics, EarlyView.
Among 15 450 Korean individuals, noncoding RNU4‐2 variants, primarily the recurrent de novo n.64_65insT, make up 0.72% of neurodevelopmental disorders. Modeling and RNA‐seq suggest U4/U6 disruption and abnormal 5′ splice‐site selection, supporting routine use of WGS analysis for reanalyzing unresolved cases. ABSTRACT Neurodevelopmental disorders (NDDs)
Juhyeon Hong, Seungbok Lee, Soo Yeon Kim, Taekeun Kim, Woong‐Hee Shin, Sesong Jang, Ji‐Hwan Park, Dongmin Jang, Gunwoo Park, Jong Ho Cha, Jae So Cho, Anna Cho, Hunmin Kim, Hyewon Woo, Jon Soo Kim, Byung Chan Lim, Ji Eun Lee, Myungshin Kim, Chong Kun Cheon, Jungmin Choi, Jong‐Hee Chae   +20 more
wiley   +1 more source

In Silico Antibacterial Activity of Polyacetilene Derivatives Against Mycobacterium tuberculosis and In-Vitro Antioxidant Properties from Ethanol Extraction of Blackjack (Bidens pilosa L.)

Jurnal Kimia Sains dan Aplikasi
Blackjack (Bidens pilosa L.) has a bioactive compound, one of which is polyacetylene, which can inhibit the growth of antimicrobials in general. This study aims to conduct an in silico study to determine the antibacterial activity against Mycobacterium ...
Firman Wicaksana, Fadila Sofi, Mohammad Rafly   +2 more
doaj   +1 more source

Contribution of direct InhA inhibitors to novel drug regimens in a mouse model of tuberculosis

Antimicrobial Agents and Chemotherapy
Isoniazid is an important first-line medicine to treat tuberculosis (TB). Isoniazid resistance increases the risk of poor treatment outcomes and development of multidrug resistance, and is driven primarily by mutations involving katG, encoding the ...
Lourdes Encinas, Si-yang Li, Joaquin Rullas-Trincado, R. Tasneen, S. Tyagi, H. Soni, A. Garcia-Perez, Jin Lee, Rubén González del Río, Jaime de Mercado, Verónica Sousa, Izidor Sosič, Stanislav Gobec, Alfonso Mendoza-Losana, P. Converse, K. Mdluli, N. Fotouhi, David Barros-Aguirre, E. Nuermberger   +18 more
semanticscholar   +1 more source

Epidemiology, Diagnosis and Management of Alopecia Areata: An Asia‐Pacific Modified Delphi Expert Panel Recommendations

International Journal of Dermatology, EarlyView.
A panel of 18 dermatologists participated in a three‐round Delphi‐based consensus process to generate a standardized framework for the diagnosis and management of alopecia areata (AA) in Asia Pacific. Recommendations focus on practicality and clinical relevance within the regional context.
Rodney Sinclair, Chao‐Chun Yang, Wen‐Hung Chung, Rachita Dhurat, Anil Ganjoo, Saranya Khunkhet, Jinran Lin, Anchala Parthasaradhi, Hyun‐Tae Shin, Kihyuk Shin, Poonkiat Suchonwanit, Kian Teo Tan, Jyh Jong Tang, Wenyu Wu, Felix Boon‐Bin Yap, Leona Yip, Angeline Yong, Cheng Zhou   +17 more
wiley   +1 more source

$K^0\Lambda$ Photoproduction with Nucleon Resonances

, 2019
We investigate the reaction mechanism of $K^0 \Lambda$ photoproduction off the neutron target, i.e., $\gamma n \to K^0 \Lambda$, in the range of $W\approx 1.6-2.2$ GeV.
Kim, Hyun-Chul, Kim, Sang-Ho
core   +1 more source

Origin of $2_1^+$ Excitation Energy Dependence on Valence Nucleon Numbers [PDF]

, 2007
It has been shown recently that a simple formula in terms of the valence nucleon numbers and the mass number can describe the essential trends of excitation energies of the first $2^+$ states in even-even nuclei.
A. Bohr, A. M. Lane, Dongwoo Cha, E. Ha, Eunja Ha   +4 more
core   +2 more sources

In silico identification of novel chemical compounds with antituberculosis activity for the inhibition of InhA and EthR proteins from Mycobacterium tuberculosis

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 2021
Tuberculosis (TB) continuously poses a major public health concern around the globe, with a mounting death toll of approximately 1.4 million in 2019. Reduced bioavailability, elevated toxicity, increased side effects, and resistance of multiple first ...
S. Halder, Fatiha Elma
semanticscholar   +1 more source