Results 211 to 220 of about 352,671 (284)

Resilience to Endoplasmic Reticulum Stress Mitigates Membrane Hyperexcitability Underlying Late Disease Onset in a Murine Model of SCA6

open access: yesAnnals of Neurology, EarlyView.
Objective An enduring puzzle in many inherited neurological disorders is the late onset of symptoms despite expression of function‐impairing mutant protein early in life. We examined the basis for onset of impairment in spinocerebellar ataxia type 6 (SCA6), a canonical late‐onset neurodegenerative ataxia which results from a polyglutamine expansion in ...
Haoran Huang   +10 more
wiley   +1 more source

Characterization of a Bioprinted Anticancer Cell Therapy System Generated with Continuous Liquid Interface Production

open access: yesAdvanced NanoBiomed Research, EarlyView.
Cell therapies often fail in the clinic due to poor in vivo persistence. In this study, we developed a 3D bioprinting strategy using continuous liquid interface production (CLIP) to generate cell therapy delivery systems. We provide a robust characterization of this new technique, demonstrating the positive effect of CLIP bioprinting on the efficacy of
Lauren Kass   +6 more
wiley   +1 more source

The SiBI™ Connector: A New Medical Device to Facilitate Preoxygenation and Reduce Waste Anesthetic Gases During Inhaled Induction with Sevoflurane

open access: bronze, 2000
Marie-José Colas   +5 more
openalex   +1 more source

Everolimus‐Coated Laser‐Cut Self‐Expandable Metallic Stent Suppresses Stent‐Induced Tissue Hyperplasia in a Rat Gastric Outlet

open access: yesAdvanced NanoBiomed Research, EarlyView.
Everolimus‐coated laser‐cut self‐expandable metallic stents suppress stent‐induced tissue hyperplasia in the gastric outlet by reducing inflammation, fibrosis, and smooth muscle proliferation. Herein, we demonstrate the mechanical stability, sustained drug release, and histological benefits in a rat gastric outlet model, suggesting potential for ...
Yubeen Park   +10 more
wiley   +1 more source

The Effect of Benralizumab and Mepolizumab on Use of Oral Glucocorticoids in Patients with Eosinophilic Granulomatosis with Polyangiitis

open access: yesArthritis &Rheumatology, Accepted Article.
Objective The Phase 3 MANDARA study demonstrated non‐inferiority of benralizumab versus mepolizumab for remission in patients with eosinophilic granulomatosis with polyangiitis (EGPA). More benralizumab‐treated patients achieved complete withdrawal of oral glucocorticoids (OGCs).
Parameswaran K. Nair   +14 more
wiley   +1 more source

Acetylcholine Receptors Do Not Mediate the Immobilization Produced by Inhaled Anesthetics

open access: bronze, 2002
Edmond I. Eger   +5 more
openalex   +1 more source

Multimodal Breathing Control: Pontomedullary Mechanisms and Current Perspectives

open access: yesBioEssays, EarlyView.
Breathing is typically automatic, ensuring homeostasis, but it is also shaped by emotion, behavior, and volition. This review synthesizes our current understanding of the flexible neural mechanisms that enable multimodal control of breathing, emphasizing the role of pontomedullary circuits.
Nathan A. Baertsch   +4 more
wiley   +1 more source

The Anesthetic Conserving Device Compared with Conventional Circle System Used Under Different Flow Conditions for Inhaled Anesthesia

open access: bronze, 2003
A Tempia   +7 more
openalex   +1 more source

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