Results 121 to 130 of about 517,479 (253)

ABCA4-associated retinopathy complicated by didanosine-associated retinal toxicity

American Journal of Ophthalmology Case Reports
Purpose: To describe a rare case of severe central and peripheral chorioretinal atrophy in a patient with ABCA4-associated retinopathy and prior didanosine exposure. Observations: A 66-year-old man with a 20-year history of Stargardt disease and HIV/AIDS
Annamaria Nunziata, Lorenzo Bianco, Alessio Antropoli, Alessandro Arrigo, Francesco Bandello, Ahmad M. Mansour, Maurizio Battaglia Parodi   +6 more
doaj   +1 more source

Pathomechanisms of Inherited Retinal Degeneration and Perspectives for Neuroprotection. [PDF]

Cold Spring Harb Perspect Med, 2023
Tolone A, Sen M, Chen Y, Ueffing M, Arango-Gonzalez B, Paquet-Durand F.   +5 more
europepmc   +1 more source

A comparative study of the potential for human retinal pigment epithelium utilising an embryonic chick model of the phenomenon [PDF]

, 2014
The retinal pigment epithelial (RPE) cells of several species, including: chicken, rat, mouse and newt, have been observed to undergo a phenomenon known as transdifferentiation.
Smart, MJK
core  

Bio‐inspired vision: From principle, material architectures to system‐level integration

FlexMat, EarlyView.
This review introduces the development and mechanism of electronic and ionic bio‐inspired vision devices respectively. Then, it explores the impact of structure on bio‐inspired visual performance from the scale of intrinsic materials and device. Finally, it concludes that only by combining advanced software and technology can more complex vision ...
Zewan Lin, Miaoyi Xu, Xianda Ma, Weifeng Yang, Yuanlong Shao   +4 more
wiley   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Ultra-high resolution OCT imaging reveals retinal layer degeneration in RD10 mice with comparison to commercial standard resolution OCT

Scientific Reports
Optical coherence tomography (OCT) imaging gives researchers a window into the structure-function relationships of the retina. This makes OCT a great tool for studying photoreceptor degeneration in vivo in mouse models of inherited retinal diseases like ...
Alexander Matteson, Maya Helms, Luke Fraley, Alexander Hurt, Anna Andrews, Elizabeth White, Paul Yang, Lesley A. Everett, Siyu Chen   +8 more
doaj   +1 more source

Utility of multimodal imaging in the clinical diagnosis of inherited retinal degenerations

Taiwan Journal of Ophthalmology
Inherited retinal degeneration (IRD) is a heterogeneous group of genetic disorders of variable onset and severity, with vision loss being a common endpoint in most cases.
Brian J. H. Lee, Christopher Z. Y. Sun, Charles J. T. Ong, Kanika Jain, Tien-En Tan, Choi Mun Chan, Ranjana S. Mathur, Rachael W. C. Tang, Yasmin Bylstra, Sylvia P. R. Kam, Weng Khong Lim, Beau J. Fenner   +11 more
doaj   +1 more source

Physiopathology of retinal degeneration in rd1 mouse model of retinitis pigmentosa TGF-Β1, proteinases and oxidative stress mechanisms

, 2009
The rd1 (retinal degeneration) mouse retina shows degeneration homologous to a form of retinitis pigmentosa with a rapid loss of rod photoreceptors and deficiency of retinal blood vessels.
Caffé, Romeo A.,, Ekström, Per,, Ahuja, Sat pal,, Veen, Theo Van,, Lund University., Ahuja-Jensen, Poonam,, Abrahamson, Magnus,   +6 more
core  

Dissecting the angiogenic mechanism of pachychoroid polypoidal choroidal vasculopathy

iMeta, EarlyView.
A prognosis‐oriented classification system was established to distinguish Pachy PCV from Non‐pachy PCV using a large multicenter dataset. Comparative plasma multi‐omics profiling of Pachy PCV, Non‐pachy PCV, and normal controls revealed unique upregulation of the fluid shear stress and atherosclerosis (FSS‐AS) and HIF‐1 signaling pathways in Pachy PCV.
Xinyu Zhao, Tiantian Cheng, Wenfei Zhang, Xingwang Gu, Qing Zhao, Yaning Chen, Lihui Meng, Jiaqi Zhang, Bintao Qiu, Lili Li, Shiyu Cheng, Zicheng Wang, Chuting Wang, Yuelin Wang, Zuyi Yang, Zhengming Shi, Ye Guo, Shengzhi Liu, Youxin Chen   +18 more
wiley   +1 more source

Graphene oxide increases the phototransduction efficiency of copolymeric nanoimplants and rescues visual functions in rat and pig models of Retinitis pigmentosa

Nature Communications
Photoreceptor degeneration in Retinitis pigmentosa (RP) is a leading cause of inherited blindness, for which few effective treatments are available. Graphene’s exceptional electrical, optical, and mechanical properties, along with its biocompatibility ...
F. Galluzzi, S. Francia, S. Cupini, T. Gianiorio, G. Mantero, M. L. DiFrancesco, T. Ravasenga, Jasnoor, M. Attanasio, J. F. Maya-Vetencourt, G. Pertile, D. Ventrella, A. Elmi, M. L. Bacci, S. Di Marco, F. Benfenati, E. Colombo   +16 more
doaj   +1 more source