Results 151 to 160 of about 517,479 (253)

Inherited Retinal Degeneration: PARP-Dependent Activation of Calpain Requires CNG Channel Activity. [PDF]

Biomolecules, 2022
Yan J, Günter A, Das S, Mühlfriedel R, Michalakis S, Jiao K, Seeliger MW, Paquet-Durand F.   +7 more
europepmc   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Effect of Lecithin-Bound Iodine Treatment on Inherited Retinal Degeneration in Mice. [PDF]

Transl Vis Sci Technol, 2021
Kohno H, Terauchi R, Watanabe S, Ichihara K, Watanabe T, Nishijima E, Watanabe A, Nakano T.   +7 more
europepmc   +1 more source

Prime editing in neuropsychiatric disorders: From mutation‐specific target selection to clinical translation

Neuroprotection, EarlyView.
Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji, Yuan Zhang, Jinyi Zhao, Yiping Lu, Chengkun Wang   +4 more
wiley   +1 more source

Lipid-Retinoid Metabolic Network Links Genetic Variation to Molecular Heterogeneity in Inherited Retinal Degeneration. [PDF]

Int J Mol Sci
Sołek P, Cholewińska E, Rejdak R, Nowomiejska K, Ognik K.   +4 more
europepmc   +1 more source

Genetic characteristics and epidemiology of inherited retinal degeneration in Taiwan. [PDF]

NPJ Genom Med, 2021
Chen TC, Huang DS, Lin CW, Yang CH, Yang CM, Wang VY, Lin JW, Luo AC, Hu FR, Chen PL.   +9 more
europepmc   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

PGC-1α and PPARs cooperatively mediate photoreceptor neuroprotection in rd1 mouse inherited retinal degeneration. [PDF]

Cell Death Dis
Wang L, Yan J, Sancho-Pelluz J, Yang Q, Hu Z, Jiao K, Seeliger MW, Paquet-Durand F.   +7 more
europepmc   +1 more source

Electrophysiology-Guided Genetic Characterisation Maximises Molecular Diagnosis in an Irish Paediatric Inherited Retinal Degeneration Population. [PDF]

Genes (Basel), 2022
Zhu J, Stephenson KAJ, Dockery A, Turner J, O'Byrne JJ, Fitzsimon S, Farrar GJ, Flitcroft DI, Keegan DJ.   +8 more
europepmc   +1 more source

Genetics of inherited retinal degeneration

, 2011
Heritable retinal degenerations dramatically affect individuals across the lifespan. Heritable degenerations with onset in childhood or young adulthood, such as the ABCA4-associated maculopathies, generally obey Mendelian segregation and are attributable
Schindler, Emily Isaak
core