Results 1 to 10 of about 4,778,507 (336)

Aesculin based glucosamine-6-phosphate synthase inhibitors as novel preservatives for food and pharmaceutical products: in-silico studies, antioxidant, antimicrobial and preservative efficacy evaluation

BMC Chemistry, 2021
Background Presently available chemical based synthetic preservative have emerged with various side effects, so the aspiration of natural and side effect free novel preservative has been greatly increased.
Amit Lather, Sunil Sharma, Anurag Khatkar   +2 more
doaj   +1 more source

Sequential presentation protects working memory from catastrophic interference [PDF]

, 2020
Neural network models of memory are notorious for catastrophic interference: old items are forgotten as new items are memorized (e.g., French, 1999; McCloskey & Cohen, 1989).
Cowan N., Gliksman Y., McCloskey M.
core   +1 more source

CuO-GO-Ag; Green Synthesis With Fagonia Arabica and Biomedical Potential is a Bioinspired Nano Theranostics Composite

Frontiers in Materials, 2022
In this study, a green synthesis strategy was used to construct CuO-GO-Ag nanocomposites (NCs) by using biological components of Fagonia arabica. Copper Oxide (CuO) nanoparticles and silver (Ag) nanoparticles were fabricated by using a plant extract of ...
Sammia Shahid, Sana Mansoor, Mohsin Javed, Shahid Iqbal, Umair Yousaf, Hashem O. Alsaab, Nasser S. Awwad, Hala A. Ibrahium, Hala A. Ibrahium, Rami M. Alzhrani, Mashael D. Alqahtani, Nissren Tamam, Eslam B. Elkaeed, Sabah Zaman, Muhammad Nazim Sarwar, Tauheeda Riaz   +15 more
doaj   +1 more source

Allosteric Inhibition of Factor XIIIa. Non-Saccharide Glycosaminoglycan Mimetics, but Not Glycosaminoglycans, Exhibit Promising Inhibition Profile [PDF]

, 2016
Factor XIIIa (FXIIIa) is a transglutaminase that catalyzes the last step in the coagulation process. Orthostery is the only approach that has been exploited to design FXIIIa inhibitors.
Afosa, Daniel K., Al-Horani, Rami A., Desai, Umesh R., Karuturi, Rajesh, Lee, Michael   +4 more
core   +10 more sources

Naringin derivatives as glucosamine-6-phosphate synthase inhibitors based preservatives and their biological evaluation

Scientific Reports, 2020
Glucosamine-6-Phosphate synthase enzyme has been targeted for development of better and safe preservative due to its role in microbial cell wall synthesis.
Amit Lather, Sunil Sharma, Anurag Khatkar   +2 more
doaj   +1 more source

Naringenin derivatives as glucosamine-6-phosphate synthase inhibitors: synthesis, antioxidants, antimicrobial, preservative efficacy, molecular docking and in silico ADMET analysis

BMC Chemistry, 2020
Background Preservatives have to be added in food, pharmaceuticals and cosmetics products to maintain their shelf life. However, the existing chemical based preservatives have been associated with severe side effects that compel the researchers to find ...
Amit Lather, Sunil Sharma, Anurag Khatkar   +2 more
doaj   +1 more source

Lead optimization for promising monoamine oxidase inhibitor from eugenol for the treatment of neurological disorder: synthesis and in silico based study

BMC Chemistry, 2019
Natural based inhibitors of monoamine oxidase are promising drug candidates for the treatment of several neurodegenerative and neuropsychological disorders including depression, anxiety, Parkinson’s disease and Alzheimer’s disease.
Priyanka Dhiman, Neelam Malik, Anurag Khatkar   +2 more
doaj   +1 more source

Natural based piperine derivatives as potent monoamine oxidase inhibitors: an in silico ADMET analysis and molecular docking studies

BMC Chemistry, 2020
Neurodegenerative disorders follow numerous pathological ways concerning overexpression of monoamine oxidase and formation of reactive oxygen species.
Priyanka Dhiman, Neelam Malik, Anurag Khatkar   +2 more
doaj   +1 more source

Hybrid caffeic acid derivatives as monoamine oxidases inhibitors: synthesis, radical scavenging activity, molecular docking studies and in silico ADMET analysis

Chemistry Central Journal, 2018
Background Monoamine oxidase has been implicated in numerous neurological disorders. Although synthetic monoamine oxidase inhibitors (MAOI) have emerged with many side effects, the aspiration of natural based MAOI has greatly increased.
Priyanka Dhiman, Neelam Malik, Anurag Khatkar   +2 more
doaj   +1 more source

PARP inhibition: a promising therapeutic target in ovarian cancer [PDF]

, 2015
Ovarian cancer is burdened by the highest mortality rate among gynecological cancers. Gold standard is represented by the association of platinum-taxane -based chemotherapy and radical surgery.
Abdul Halim, T, BENEDETTI PANICI, PIERLUIGI, CASORELLI, ASSUNTA, DI DONATO, VIOLANTE, DOMENICI, LAVINIA, GASPARRI, MARIALUISA, IMPERIALE, LUDOVICA, MARCHETTI, CLAUDIA, MONTI, Marco, MUSELLA, ANGELA, MUZII, LUDOVICO, PALAIA, INNOCENZA, PECORINI, Francesco, RUSCITO, ILARY, SALERNO, LAURA   +14 more
core   +1 more source