Results 91 to 100 of about 6,274,440 (386)

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

From simple receptors to complex multimodal percepts: A first global picture on the mechanisms involved in perceptual binding

Frontiers in Psychology, 2012
The binding problem in perception is concerned with answering the question how information from millions of sensory receptors, processed by millions of neurons working in parallel, can be merged into a unified percept.
Rosemarie eVelik
doaj   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Impaired Competence for Pretense in Children with Autism: Exploring Potential Cognitive Predictors. [PDF]

, 2009
Lack of pretense in children with autism has been explained by a number of theoretical explanations, including impaired mentalising, impaired response inhibition, and weak central coherence.
AM Leslie, AM Leslie, AM Leslie, AS Lillard, B Morgan, BG Tabachnick, C Hughes, C Jarrold, C Jarrold, C Jarrold, C Jarrold, DM Ricks, F Happé, F Happé, G Miller, H Wimmer, HA Witkin, J Boucher, J Perner, L Mottron, LM Dunn, M Taylor, MD Rutherford, P Rochat, PL Harris, RD Kavanaugh, S Baron-Cohen, S Baron-Cohen, S Baron-Cohen, S Bigham, S Bigham, Sally Bigham, T Suddendorf, U Frith, U Frith, V Lewis, W Haight   +36 more
core   +1 more source

Molecular modeling, synthesis and biological evaluation of caffeic acid based Dihydrofolate reductase inhibitors

BMC Chemistry
Dihydrofolate reductase (DHFR) is an enzyme that plays a crucial role in folate metabolism, which is essential for cell growth and division. DHFR has been identified as a molecular target for numerous diseases due to its significance in various ...
Renu Sehrawat, Ritu Pasrija, Priyanka Rathee, Deepika Kumari, Anurag Khatkar   +4 more
doaj   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group.

New England Journal of Medicine, 1993
BACKGROUND Renal function declines progressively in patients who have diabetic nephropathy, and the decline may be slowed by antihypertensive drugs. The purpose of this study was to determine whether captopril has kidney-protecting properties independent
E. Lewis, L. Hunsicker, R. Bain, R. Rohde   +3 more
semanticscholar   +1 more source

Asymmetric ephaptic inhibition between compartmentalized olfactory receptor neurons. [PDF]

, 2019
In the Drosophila antenna, different subtypes of olfactory receptor neurons (ORNs) housed in the same sensory hair (sensillum) can inhibit each other non-synaptically.
Bushong, Eric A, Chiang, Ann-Shyn, Chu, Li-An, Ellisman, Mark H, Reingruber, Jürgen, Su, Chih-Ying, Tsang, Tin Ki, Zhang, Ye   +7 more
core   +3 more sources

Response Inhibition and Interference Suppression in Individuals With Down Syndrome Compared to Typically Developing Children

Frontiers in Psychology, 2018
The present study aims to investigate inhibition in individuals with Down Syndrome compared to typically developing children with different inhibitory tasks tapping response inhibition and interference suppression.
Laura Traverso, Martina Fontana, Maria Carmen Usai, Maria C. Passolunghi   +3 more
doaj   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source