Results 131 to 140 of about 4,033,279 (373)

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink   +6 more
wiley   +1 more source

Creative Thinking and Dyscalculia: Conjectures About a Still Unexplored Link

open access: yesFrontiers in Psychology, 2021
Sara Magenes   +3 more
doaj   +1 more source

Emotion Potentiates Response Activation and Inhibition in Masked Priming

open access: yesFrontiers in Integrative Neuroscience, 2012
Previous studies have shown that emotion can have two-fold effects on perception. At the object-level, emotional stimuli benefit from a stimulus-specific boost in visual attention at the relative expense of competing stimuli. At the visual feature-level,
Bruno eBocanegra, Rene eZeelenberg
doaj   +1 more source

Overcoming inhibitions [PDF]

open access: yesProceedings of the National Academy of Sciences, 2006
Organophosphorus nerve agents and pesticides (Fig. 1) markedly increase the amount and duration of the action of acetylcholine at all of the synaptic sites where it acts, resulting in overstimulation of critical processes that can lead to incapacitation, muscle paralysis, and death. In a recent issue of PNAS, Albuquerque et al. (1) reported that a drug
openaire   +3 more sources

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

open access: yesNature Network Boston, 2013
Glioblastoma multiforme (GBM) comprises several molecular subtypes, including proneural GBM. Most therapeutic approaches targeting glioma cells have failed.
S. Pyonteck   +19 more
semanticscholar   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi   +3 more
wiley   +1 more source

A single GABAergic neuron mediates feedback of odor-evoked signals in the mushroom body of larval Drosophila

open access: yesFrontiers in Neural Circuits, 2014
Inhibition has a central role in defining the selectivity of the responses of higher order neurons to sensory stimuli. However, the circuit mechanisms of regulation of these responses by inhibitory neurons are still unclear.
Liria Monica Masuda-Nakagawa   +3 more
doaj   +1 more source

Fine Discrimination of Analog Patterns by Nonlinear Dendritic Inhibition [PDF]

open access: yesarXiv, 2004
Recent experiments revealed that a certain class of inhibitory neurons in the cerebral cortex make synapses not onto cell bodies but at distal parts of dendrites of the target neurons, mediating highly nonlinear dendritic inhibition. We propose a novel form of competitive neural network model that realizes such dendritic inhibition.
arxiv  

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

open access: yesMolecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker   +14 more
wiley   +1 more source

Home - About - Disclaimer - Privacy