Results 131 to 140 of about 4,254,417 (298)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Research of the Common-mode Voltage Inhibition for Three-level NPC Inverter

Kongzhi Yu Xinxi Jishu, 2015
Adopting NPC(Neutral Point Clamped) three-level inverters as a research object, it analyzed three control strategies for common-mode voltage inhibition, such as traditional three -level SVPWM, SVPWM for reducing common-mode voltage and SVPWM for ...
DING Guanyuan, LI Yinling, LI Kai
doaj  

Corticocortical inhibition in human motor cortex.

Journal of Physiology, 1993
T. Kujirai, M. Caramia, J. Rothwell, B. Day, P. Thompson, A. Ferbert, S. Wroe, P. Asselman, C. Marsden   +8 more
semanticscholar   +1 more source

Table S3 from Integrative Kinome Profiling Identifies mTORC1/2 Inhibition as Treatment Strategy in Ovarian Clear Cell Carcinoma

, 2023
Joseph J. Caumanns, Katrien Berns, G. Bea A. Wisman, Rudolf S.N. Fehrmann, Tushar Tomar, Harry Klip, Gert Jan Meersma, E. Marielle Hijmans, Annemiek M.C. Gennissen, Evelien W. Duiker, Desirée Weening, Hiroaki Itamochi, Roelof J.C. Kluin, Anna K.L. Reyners, Michael J. Birrer, Helga B. Salvesen, Ignace Vergote, Els Van Nieuwenhuysen, James D. Brenton, Elena Ioana Braicu, Jolanta Kupryjańczyk, Beata Śpiewankiewicz, Lorenza Mittempergher, René Bernards, Ate G.J. van der Zee, Steven de Jong   +25 more
openalex   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Inhibition of mutated, activated BRAF in metastatic melanoma.

New England Journal of Medicine, 2010
K. Flaherty, I. Puzanov, Kevin B. Kim, A. Ribas, G. McArthur, J. Sosman, P. O'dwyer, Richard J Lee, J. Grippo, K. Nolop, P. Chapman   +10 more
semanticscholar   +1 more source

Supplementary Figure Legends from Wee-1 Kinase Inhibition Overcomes Cisplatin Resistance Associated with High-Risk <i>TP53</i> Mutations in Head and Neck Cancer through Mitotic Arrest Followed by Senescence

, 2023
Abdullah A. Osman, Marcus M. Monroe, Marcus V. Ortega Alves, Ameeta A. Patel, Panagiotis Katsonis, Alison L. Fitzgerald, David M. Neskey, Mitchell J. Frederick, Sang Hyeok Woo, Carlos Caulı́n, Teng‐Kuei Hsu, Thomas O. McDonald, Marek Kimmel, Raymond E. Meyn, Olivier Lichtarge, Jeffrey N. Myers   +15 more
openalex   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer.

New England Journal of Medicine, 2010
E. Kwak, Y. Bang, D. Camidge, A. Shaw, B. Solomon, Robert G. Maki, Sai-Hong Ignatius Ou, B. Dezube, P. Jänne, Daniel, B. Costa, M. Varella-Garcia, W. Kim, Thomas J. Lynch, P. Fidias, Hannah Stubbs, J. Engelman, V. Lecia, Sequist, Weiwei Tan, L. Gandhi, M. Mino‐Kenudson, Greg C. Wei, S. M. Shreeve, M. Ratain, Jeffrey, Settleman, James G. Christensen, D. Haber, K. Wilner, R. Salgia, Geoffrey I. Shapiro, J. Clark, A. Iafrate   +33 more
semanticscholar   +1 more source

Phagocytosis inhibition of clam and mussel haemocytes by Perkinsus atlanticus secretion products.

, 1999
M. Camino Ordás, Beatriz Novoa, António Figueras   +2 more
openalex   +2 more sources