Results 41 to 50 of about 4,778,507 (336)
Inhibiting the Inhibition: A Neuronal Network for Sound Localization in Reverberant Environments [PDF]
The precedence effect describes the phenomenon whereby echoes are spatially fused to the location of an initial sound by selectively suppressing the directional information of lagging sounds (echo suppression). Echo suppression is a prerequisite for faithful sound localization in natural environments but can break down depending on the behavioral ...
Pecka, Michael+8 more
openaire +3 more sources
Feedback Enhances Preschoolers’ Performance in an Inhibitory Control Task
Accomplishing inhibition tasks requires not only inhibitory skills but also goal maintenance. The present study aimed to disentangle goal maintenance from inhibition. Therefore, we experimentally manipulated goal-maintenance demands by means of feedback.
Niamh Oeri+3 more
doaj +1 more source
When our brain detects an error, this process changes how we react on ensuing trials. People show post-error adaptations, potentially to improve their performance in the near future.
Claudia eDanielmeier+2 more
doaj +1 more source
Dual mTOR/PI3K inhibition limits PI3K-dependent pathways activated upon mTOR inhibition in autosomal dominant polycystic kidney disease [PDF]
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the development of kidney cysts leading to kidney failure in adulthood. Inhibition of mammalian target of rapamycin (mTOR) slows polycystic kidney disease (PKD) progression in ...
Arcaro, Alexandre+10 more
core +2 more sources
Behavioral and neuroimaging data support the distinction of two different modes of cognitive control: proactive, which involves the active and sustained maintenance of task-relevant information to bias behavior in accordance with internal goals; and ...
Carlos J. Gómez-Ariza+2 more
doaj +1 more source
Impaired response inhibition and excess cortical thickness as candidate endophenotypes for trichotillomania. [PDF]
Trichotillomania is characterized by repetitive pulling out of one's own hair. Impaired response inhibition has been identified in patients with trichotillomania, along with gray matter density changes in distributed neural regions including frontal ...
Chamberlain, Samuel R.+4 more
core +3 more sources
Inhibition is considered an essential process to goal pursuit and as a result has become a central construct in many disciplines in psychology and adjacent fields. Despite a century’s worth of debate, however, there is little consensus about what inhibition actually is.
Kaitlyn M. Werner+2 more
openaire +3 more sources
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Basal Forebrain Mediates Motivational Recruitment of Attention by Reward-Associated Cues
The basal forebrain, composed of distributed nuclei, including substantia innominata (SI), nucleus basalis and nucleus of the diagonal band of Broca plays a crucial neuromodulatory role in the brain.
Faezeh Tashakori-Sabzevar, Ryan D. Ward
doaj +1 more source