Results 41 to 50 of about 6,274,440 (386)
International Journal of Molecular Sciences, 2023 Cancer metastasis is a common biological phenomenon observed in malignant tumors that can lead to death in affected individuals [...]
Masa-Aki Shibata, Kohei Taniguchi
openaire +2 more sources
Synthesis of novel azo compounds containing 5(4H)-oxazolone ring as potent tyrosinase inhibitors [PDF]
, 2013 Six new azo dyes containing of 5(4H)-oxazolone ring were prepared by diazotization of 4-aminohippuric acid and coupling with N,N-dimethylaniline, 1-naphthol and 2-naphthol and condensation with 4-fluoro benzaldehyde or 4-trifluoromethoxy benzaldehyde ...
Abbasalipour, V. +5 more
core +1 more source
Synthesis and evaluation of AKR1C inhibitory properties of A-ring halogenated oestrone derivatives
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 Enzymes AKR1C regulate the action of oestrogens, androgens, and progesterone at the pre-receptor level and are also associated with chemo-resistance. The activities of these oestrone halides were investigated on recombinant AKR1C enzymes.
Maša Sinreih +6 more
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Acquired Resistance to KRASG12C Inhibition in Cancer.
New England Journal of Medicine, 2021 BACKGROUND Clinical trials of the KRAS inhibitors adagrasib and sotorasib have shown promising activity in cancers harboring KRAS glycine-to-cysteine amino acid substitutions at codon 12 (KRASG12C).
M. Awad +36 more
semanticscholar +1 more source
Tetracycline Actions Relevant to Rosacea Treatment [PDF]
, 2009 Until today, the pathogenesis of rosacea is not known in detail. Yet in recent years evidence has been accumulating that rosacea with its common symptoms such as inflammatory lesions, erythema, telangiectasia, phymatous changes, and ocular symptoms is of
Korting, Hans Christian, Schöllmann, C.
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The general anaesthetic etomidate inhibits the excitability of mouse thalamocortical relay neurons by modulating multiple modes of GABAA receptor-mediated inhibition [PDF]
, 2014 Modulation of thalamocortical (TC) relay neuron function has been implicated in the sedative and hypnotic effects of general anaesthetics. Inhibition of TC neurons is mediated predominantly by a combination of phasic and tonic inhibition, together with a
Alkire +57 more
core +2 more sources
Inhibition of mutated, activated BRAF in metastatic melanoma.
New England Journal of Medicine, 2010 BACKGROUND The identification of somatic mutations in the gene encoding the serine-threonine protein kinase B-RAF (BRAF) in the majority of melanomas offers an opportunity to test oncogene-targeted therapy for this disease.
K. Flaherty +10 more
semanticscholar +1 more source
The Origin of Neocortical Nitric Oxide Synthase-expressing Neurons
Frontiers in Neural Circuits, 2012 Inhibitory neurons are critical for regulating effective transfer of sensory information and network stability. The precision of inhibitory function likely derives from the existence of a variety of interneuron subtypes.
Xavier H. Jaglin +5 more
doaj +1 more source
CRUDE GLYCEROL AS SUBSTRATE FOR SULFATE-REDUCING BACTERIA FROM A MATURE OIL FIELD AND ITS POTENTIAL IMPACT ON SOURING [PDF]
Journal of Petroleum Science and Technology, 2015 Crude glycerol (CG) is an abundantly available and cheap by-product from biodiesel production. Value-added applications for CG are highly wanted by industry and several processes such as the use of CG for enhanced oil recovery have been proposed. The aim
Sidnei Santos +7 more
doaj +1 more source