Results 41 to 50 of about 4,254,417 (298)

CDK4/6 inhibition triggers anti-tumor immunity

Nature, 2017
Cyclin-dependent kinases 4 and 6 (CDK4/6) are fundamental drivers of the cell cycle and are required for the initiation and progression of various malignancies.
S. Goel, Molly J Decristo, April C. Watt, Haley BrinJones, Jaclyn Sceneay, Ben B. Li, N. Khan, Jessalyn M. Ubellacker, Shaozhen Xie, O. Metzger-Filho, J. Hoog, M. Ellis, Cynthia X. Ma, S. Ramm, I. Krop, E. Winer, T. Roberts, Hye-Jung Kim, S. McAllister, Jean J. Zhao   +19 more
semanticscholar   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Purification and Component Analysis of Total Flavonoids from Sea Buckthorn Peel Residue and Its Anti-Pancreatic Lipase

Shipin gongye ke-ji
In order to clarify the inhibition of total flavonoids purified extract (TFSE) of sea buckthorn peel residue on pancreatic lipase, this research optimized the purification condition of total flavonoids crude extract (TFCE) of sea buckthorn peel residue ...
Jiali SUN, Junfeng JIANG, Xiaojuan MOU, Zehui ZONG, Siyu YAN, JIALALIDING·Remuzha, Xiaowei BAO   +6 more
doaj   +1 more source

Morphological and Transcriptomic Analysis of the Inhibitory Effects of Lactobacillus plantarum on Aspergillus flavus Growth and Aflatoxin Production

Toxins, 2019
Lactobacillus plantarum, as a natural bio-preservative, has attracted a great deal of attention in recent years. In this study, 22 L. plantarum strains were tested against the aflatoxin-producing fungus, Aspergillus flavus; strain IAMU80070 showed the ...
Yueju Zhao, Chenxi Zhang, Yawa Minnie Elodie Folly, Jinghua Chang, Yan Wang, Lu Zhou, Heping Zhang, Yang Liu   +7 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Measuring semantic memory using associative and dissociative retrieval tasks

Royal Society Open Science
Recent theoretical advances highlighted the need for novel means of assessing semantic cognition. Here, we introduce the associative-dissociative retrieval task (ADT), positing a novel way to test inhibitory control over semantic memory retrieval by ...
Martin Marko, Drahomír Michalko, Adam Kubinec, Igor Riečanský   +3 more
doaj   +1 more source

Inducible nitric oxide synthase: Regulation, structure, and inhibition

Medicinal research reviews (Print), 2020
A considerable number of human diseases have an inflammatory component, and a key mediator of immune activation and inflammation is inducible nitric oxide synthase (iNOS), which produces nitric oxide (NO) from l‐arginine.
Maris A. Cinelli, H. Do, Galen P. Miley, R. Silverman   +3 more
semanticscholar   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Molecular modeling, synthesis and biological evaluation of caffeic acid based Dihydrofolate reductase inhibitors

BMC Chemistry
Dihydrofolate reductase (DHFR) is an enzyme that plays a crucial role in folate metabolism, which is essential for cell growth and division. DHFR has been identified as a molecular target for numerous diseases due to its significance in various ...
Renu Sehrawat, Ritu Pasrija, Priyanka Rathee, Deepika Kumari, Anurag Khatkar   +4 more
doaj   +1 more source

Lactobacillus plantarum supernatant inhibits growth of Riemerella anatipestifer and mediates intestinal antimicrobial defense in Muscovy ducks

Poultry Science
: Riemerella anatipestifer (RA) is an important pathogen of waterfowl, with multiple serotypes and a lack of cross-protection between each serotype, which leads to the continued widespread in the world and causing significant economic losses to the duck ...
Zhaolong Li, Qing Guo, Fengqiang Lin, Cuiting Li, Lu Yan, Haiou Zhou, Yaping Huang, Binbin Lin, Bilin Xie, Zhimin Lin, Yu Huang   +10 more
doaj   +1 more source