Results 51 to 60 of about 6,274,440 (386)
Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer.
New England Journal of Medicine, 2010 BACKGROUND Oncogenic fusion genes consisting of EML4 and anaplastic lymphoma kinase (ALK) are present in a subgroup of non-small-cell lung cancers, representing 2 to 7% of such tumors. We explored the therapeutic efficacy of inhibiting ALK in such tumors
E. Kwak +33 more
semanticscholar +1 more source
Potent CRISPR-Cas9 inhibitors from Staphylococcus genomes. [PDF]
, 2020 Anti-CRISPRs (Acrs) are small proteins that inhibit the RNA-guided DNA targeting activity of CRISPR-Cas enzymes. Encoded by bacteriophage and phage-derived bacterial genes, Acrs prevent CRISPR-mediated inhibition of phage infection and can also block ...
Doudna, Jennifer A +5 more
core +3 more sources
Inhibition In The Medus?? [PDF]
The Journal of Nervous and Mental Disease, 1904 n ...
openaire +3 more sources
The E5 protein of BPV-4 interacts with the heavy chain of MHC class I and irreversibly retains the MHC complex in the Golgi apparatus [PDF]
, 2006 BPV-4 E5 inhibits transcription of the bovine MHC class I heavy chain (HC) gene, increases degradation of HC and downregulates surface expression of MHC class I by retaining the complex in the Golgi apparatus (GA).
Araibi, E.H. +5 more
core +1 more source
Clinical Chemistry, 2019 Some old methods are still in use because they are simple and effective. One such method is the disk diffusion (or agar diffusion) test (1, 2). The diameter of the clear zone around an antibiotic-paper disk enables us to directly, and elegantly, visualize the inhibitory potency of an antibiotic. This test is …
openaire +4 more sources
Inhibition in multiclass classification [PDF]
, 2012 The role of inhibition is investigated in a multiclass support vector machine formalism inspired by the brain structure of insects. The so-called mushroom bodies have a set of output neurons, or classification functions, that compete with each other to ...
Bottou L. +17 more
core +1 more source
Observations related to the causes and consequences of stuck fermentation in vinification
OENO One, 1999 The serious dangers arising if premature arrest of alcoholic fermentation (stuck fermentation) occurs are well known. If sugar is present, bacteria development may increase volatile acidity.
Pascal Ribéreau-Gayon
doaj +1 more source
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.
New England Journal of Medicine, 2009 BACKGROUND The inhibition of poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) is a potential synthetic lethal therapeutic strategy for the treatment of cancers with specific DNA-repair defects, including those arising in carriers of a BRCA1 or ...
P. Fong +14 more
semanticscholar +1 more source
Electrostatic Contributions of Aromatic Residues in the Local Anesthetic Receptor of Voltage-Gated Sodium Channels [PDF]
, 2008 Antiarrhythmics, anticonvulsants, and local anesthetics target voltage-gated sodium channels, decreasing excitability of nerve and muscle cells. Channel inhibition by members of this family of cationic, hydrophobic drugs relies on the presence of highly ...
Ahern, Christopher A. +3 more
core +2 more sources
Genes & Development, 2007 The Hippo pathway plays a key role in organ size control by regulating cell proliferation and apoptosis in Drosophila. Although recent genetic studies have shown that the Hippo pathway is regulated by the NF2 and Fat tumor suppressors, the physiological ...
Bin Zhao +15 more
semanticscholar +1 more source