Results 51 to 60 of about 4,033,279 (373)
Genes & Development, 2007 The Hippo pathway plays a key role in organ size control by regulating cell proliferation and apoptosis in Drosophila. Although recent genetic studies have shown that the Hippo pathway is regulated by the NF2 and Fat tumor suppressors, the physiological ...
Bin Zhao +15 more
semanticscholar +1 more source
KRASG12C Inhibition with Sotorasib in Advanced Solid Tumors.
New England Journal of Medicine, 2020 BACKGROUND No therapies for targeting KRAS mutations in cancer have been approved. The KRAS p.G12C mutation occurs in 13% of non-small-cell lung cancers (NSCLCs) and in 1 to 3% of colorectal cancers and other cancers.
D. Hong +33 more
semanticscholar +1 more source
The Modulatory Role of Cortisol in the Regulation of Sexual Behavior in Young Males
Frontiers in Behavioral Neuroscience, 2020 The proneness to be sexually aroused, to perform sexual acts, or to be sexually disinhibited during a particular mood varies across individuals. However, the physiological mechanisms underlying this specific and variable relationship between mood and sex-
Geraldine Rodríguez-Nieto +5 more
doaj +1 more source
Reductions in Depth-integrated Picophytoplanktonic Photosynthesis Due to Inhibition by Ultraviolet and Photosynthetically Available Radiation: Global Predictions for $\textit{Prochlorococcus}$ and $\textit{Synechococcus}$ [PDF]
, 2016 Phytoplankton photosynthesis in most natural waters is often inhibited by ultraviolet (UV) and intense photosynthetically available radiation (PAR) but the effects on ocean productivity have received little consideration aside from polar areas subject to periodic enhanced UV-B due to depletion of stratospheric ozone.
arxiv +1 more source
NMDAR inhibition-independent antidepressant actions of ketamine metabolites
Nature, 2016 Major depressive disorder affects around 16 per cent of the world population at some point in their lives. Despite the availability of numerous monoaminergic-based antidepressants, most patients require several weeks, if not months, to respond to these ...
P. Zanos +19 more
semanticscholar +1 more source
FEBS Letters, EarlyView.In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali +3 more
wiley +1 more source
Current Directions in Psychological Science, 2022 Inhibition is considered an essential process to goal pursuit and as a result has become a central construct in many disciplines in psychology and adjacent fields. Despite a century’s worth of debate, however, there is little consensus about what inhibition actually is.
Kaitlyn M. Werner +2 more
openaire +3 more sources
Depression and Anxiety, 2021 Over the past 25 years, our understanding of the risks conferred by “behavioral inhibition to the unfamiliar” (BI) has grown tremendously, yet many questions remain.
D. Hirshfeld-Becker +5 more
semanticscholar +1 more source
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source