Results 71 to 80 of about 6,274,440 (386)

Gain control with A-type potassium current: IA as a switch between divisive and subtractive inhibition [PDF]

, 2018
Neurons process information by transforming barrages of synaptic inputs into spiking activity. Synaptic inhibition suppresses the output firing activity of a neuron, and is commonly classified as having a subtractive or divisive effect on a neuron's ...
Goldwyn, Joshua H, Slabe, Bradley R, Terman, David, Travers, Joseph B   +3 more
core   +4 more sources

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Inhibition of Bifidobacterium SP Isolated From Infants Feces Towards Adhesion of Salmonella Typhi on Balb/c Mice Enterocyte [PDF]

, 2010
Diarrhea, up to the recent year remains a cause of high morbidity and mortalityworldwide, especially in developing countries including Indonesia. Research concerning ofmanagement, prevention, and medication of the disease have been continually improved ...
Astawa, N. M. (N), Sukardika, K. (K), Sukrama, I. D. (I), Sumarno, S. (Sumarno)   +3 more
core  

Reconciling the influence of task-set switching and motor inhibition processes on stop signal after-effects. [PDF]

, 2013
Executive response functions can be affected by preceding events, even if they are no longer associated with the current task at hand. For example, studies utilizing the stop signal task have reported slower response times to "GO" stimuli when the ...
Anguera, Joaquin A, Bollinger, Jacob, Gazzaley, Adam, Lyman, Kyle, Zanto, Theodore P   +4 more
core   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Angiotensin–Neprilysin Inhibition in Acute Decompensated Heart Failure

New England Journal of Medicine, 2019
BACKGROUND Acute decompensated heart failure accounts for more than 1 million hospitalizations in the United States annually. Whether the initiation of sacubitril–valsartan therapy is safe and effective among patients who are hospitalized for acute ...
E. Velazquez, D. Morrow, A. DeVore, Carol I. Duffy, A. Ambrosy, K. Mccague, Ricardo A. Rocha, E. Braunwald   +7 more
semanticscholar   +1 more source

Inducible nitric oxide synthase: Regulation, structure, and inhibition

Medicinal research reviews (Print), 2020
A considerable number of human diseases have an inflammatory component, and a key mediator of immune activation and inflammation is inducible nitric oxide synthase (iNOS), which produces nitric oxide (NO) from l‐arginine.
Maris A. Cinelli, H. Do, Galen P. Miley, R. Silverman   +3 more
semanticscholar   +1 more source

Inhibitory Effects of Dietary N-Glycans From Bovine Lactoferrin on Toll-Like Receptor 8; Comparing Efficacy With Chloroquine

Frontiers in Immunology, 2020
Toll-like receptor 8 (TLR-8) plays a role in the pathogenesis of autoimmune disorders and associated gastrointestinal symptoms that reduce quality of life of patients. Dietary interventions are becoming more accepted as mean to manage onset, progression,
Susana Figueroa-Lozano, Rivca L. Valk-Weeber, Renate Akkerman, Wayel Abdulahad, Sander S. van Leeuwen, Lubbert Dijkhuizen, Paul de Vos   +6 more
doaj   +1 more source

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

FEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa, Cong Lin, Irina A. Talyzina, Marina V. Goncharuk, Eduard V. Bocharov, Alexander S. Arseniev, Xiaohui Wang, Sergey A. Goncharuk, Konstantin S. Mineev   +8 more
wiley   +1 more source