Results 71 to 80 of about 4,254,417 (298)

Excitation-Inhibition Balanced Neural Networks for Fast Signal Detection [PDF]

, 2020
Gengshuo Tian, Shangyang Li, Tiejun Huang, Si Wu   +3 more
openalex   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Lignocellulosic composites from brazilian giant bamboo (Guadua magna). Part 2: Properties of cement and gypsum bonded particleboards

Maderas: Ciencia y Tecnología, 2014
In the first part of this study, the feasibility of manufacturing resin-bonded particleboard from the recently identified Brazilian giant bamboo (Guadua magna) was evaluated.
Priscila C. de Araújo, Larissa M. Arruda, Cláudio H. S. Del Menezzi, Divino E. Teixeira, Mário R. de Souza   +4 more
doaj  

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Inhibition of SARS-CoV 3CL protease by flavonoids

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
There were severe panics caused by Severe Acute Respiratory Syndrome (SARS) and Middle-East Respiratory Syndrome-Coronavirus. Therefore, researches targeting these viruses have been required.
S. Jo, Suwon Kim, D. Shin, Mi‐Sun Kim
semanticscholar   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Navigating Drug–Drug Interactions in Clinical Drug Development: A Tutorial

Clinical and Translational Science
This tutorial provides essential guidelines and insights, in addition to regulatory guidance, for the evaluation of drug–drug interactions (DDIs), with a focus on the tools and timing of assessment critical for effective management of inclusion/exclusion
Jesmin Lohy Das, Antoinette (Toni) Ajavon‐Hartmann, Virginia (Ginny) D. Schmith   +2 more
doaj   +1 more source

Effect of diethylstilbestrol on skin sterols of the male rat

Journal of Lipid Research, 1968
Diethylstilbestrol (DES) was injected in doses ranging from 600 μg to 0.4 μg/kg body weight into mature male rats over a 3 wk period. Profound effects on skin morphology and on sterol content of skin were noted.
L. Horlick
doaj   +1 more source

N -myristoyltransferase inhibition is synthetic lethal in MYC-deregulated cancers [PDF]

, 2021
Gregor A. Lueg, Monica Faronato, Andrii Gorelik, Andrea Goya Grocin, Eva Caamaño‐Gutiérrez, Francesco Falciani, Roberto Solari, Robin A. E. Carr, Andrew Bell, Edward Bartlett, J.A. Hutton, Miriam Llorian, Probir Chakravarty, Bernadette Brzezicha, Martin Janz, Mathew J. Garnett, Dinis Pedro Calado, Edward W. Tate   +17 more
openalex   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source