Results 71 to 80 of about 6,364,217 (385)

Cardiac hypertrophy is inhibited by a local pool of cAMP regulated by phosphodiesterase 2 [PDF]

, 2015
Rationale: Chronic elevation of 3'-5'-cyclic adenosine monophosphate (cAMP) levels has been associated with cardiac remodelling and cardiac hypertrophy.
Aronsen, Jan M., Baillie, George S., Corsetti, Veronica, Dodoni, Giuliano, Fields, Laura A., Furlan, Leonardo, Gesellchen, Frank, Graham, Delyth, Hamilton, Graham M., Jiang, He, Krall, Judith, Lefkimmiatis, Konstantinos, Livie, Craig, Mancuso, Luisa, Movsesian, Matthew, Nicklin, Stuart A., Sin, Yuan Yan, Sjaastad, Ivar, Stangherlin, Alessandra, Surdo, Nicoletta C., Szabo-Fresnais, Nicolas, Terrin, Anna, Vandeput, Fabrice, Zaccolo, Manuela, Zoccarato, Anna   +24 more
core   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Tightly coupled inhibitory and excitatory functional networks in the developing primary visual cortex

eLife, 2021
Intracortical inhibition plays a critical role in shaping activity patterns in the mature cortex. However, little is known about the structure of inhibition in early development prior to the onset of sensory experience, a time when spontaneous activity ...
Haleigh N Mulholland, Bettina Hein, Matthias Kaschube, Gordon B Smith   +3 more
doaj   +1 more source

Angiotensin–Neprilysin Inhibition in Acute Decompensated Heart Failure

New England Journal of Medicine, 2019
BACKGROUND Acute decompensated heart failure accounts for more than 1 million hospitalizations in the United States annually. Whether the initiation of sacubitril–valsartan therapy is safe and effective among patients who are hospitalized for acute ...
E. Velazquez, D. Morrow, A. DeVore, Carol I. Duffy, A. Ambrosy, K. Mccague, Ricardo A. Rocha, E. Braunwald   +7 more
semanticscholar   +1 more source

Inducible nitric oxide synthase: Regulation, structure, and inhibition

Medicinal research reviews (Print), 2020
A considerable number of human diseases have an inflammatory component, and a key mediator of immune activation and inflammation is inducible nitric oxide synthase (iNOS), which produces nitric oxide (NO) from l‐arginine.
Maris A. Cinelli, H. Do, Galen P. Miley, R. Silverman   +3 more
semanticscholar   +1 more source

Behavioral inhibition

Depression and Anxiety, 2021
Over the past 25 years, our understanding of the risks conferred by “behavioral inhibition to the unfamiliar” (BI) has grown tremendously, yet many questions remain.
D. Hirshfeld-Becker, Jamie A. Micco, A. Henin, A. Bloomfield, J. Biederman, J. Rosenbaum   +5 more
semanticscholar   +1 more source

Phytochemical analysis and in-vitro antiurolithiatic properties of selected Malaysian herbs [PDF]

, 2019
The aim of this study was to investigate the phytochemical content of selected Malaysian herbs and their potential antiurolithiatic effects using in-vitro method.
A. Talip, Balkis, Abdul Rahim, Nur Fazira, Abdullah, Norazlin, Abu Bakar, Mohd Fadzelly, Muhammad, Norhayati, Sairi, Nur Halimah, Wan Marzuki Rashidi, Wan Nur Ain Syukriah   +6 more
core  

Impaired response inhibition and excess cortical thickness as candidate endophenotypes for trichotillomania. [PDF]

, 2014
Trichotillomania is characterized by repetitive pulling out of one's own hair. Impaired response inhibition has been identified in patients with trichotillomania, along with gray matter density changes in distributed neural regions including frontal ...
Chamberlain, Samuel R., Derbyshire, Katie L., Grant, Jon E., Leppink, Eric W., Odlaug, Brian L.   +4 more
core   +3 more sources

Inhibition In The Medus?? [PDF]

The Journal of Nervous and Mental Disease, 1904
n ...
openaire   +2 more sources

Mechanisms and kinetic assays of aminoacyl‐tRNA synthetases

FEBS Letters, EarlyView.
Accurate protein synthesis is crucial for life. The key players are aminoacyl‐tRNA synthetases (AARSs), which read the genetic code by pairing cognate amino acids and tRNAs. AARSs establish high amino acid selectivity by employing physicochemical limits in molecular recognition.
Igor Zivkovic, Morana Dulic, Ita Gruic‐Sovulj   +2 more
wiley   +1 more source