Results 241 to 250 of about 2,456,442 (305)

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Study on Oleum cinnamomi Inhibiting Cutibacterium acnes and Its Covalent Inhibition Mechanism. [PDF]

Molecules
Peng H, Chu C, Jin L, Zhang J, Yang Z, Zhu L, Yang D, Zhao Z.   +7 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Insights into the Synergistic Effect and Inhibition Mechanism of Composite Conditioner on Sulfur-Containing Gases during Sewage Sludge Pyrolysis. [PDF]

Molecules
Cheng S, Chen L, Wang S, Yao K, Tian H.
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Studies on the Inhibition Mechanism of Linalyl Alcohol against the Spoilage Microorganism Brochothrix thermosphacta. [PDF]

Foods
Wang L, Liu X, Chen W, Sun Z.
europepmc   +1 more source

Transport and inhibition mechanism for VMAT2-mediated synaptic vesicle loading of monoamines. [PDF]

Cell Res
Wang Y, Zhang P, Chao Y, Zhu Z, Yang C, Zhou Z, Li Y, Long Y, Liu Y, Li D, Wang S, Qu Q.   +11 more
europepmc   +1 more source

Exploring the Experimental and Theoretical Studies and Inhibition Mechanism of Passiflora Incarnata Extract as a Novel Green Inhibitor for API 5CT N80 in an Aggressive Environment. [PDF]

ACS Omega
Alamry AYH, Al-Subaie NS, Alshahrani WS, Shanab MMAH, Motawea MM.   +4 more
europepmc   +1 more source

Study on the Inhibition Mechanism of Hydration Expansion of Yunnan Gas Shale using Modified Asphalt. [PDF]

Materials (Basel)
Dai Z, Sun J, Liu J, Lv K, Zhang X, Wang Z, Xu Z.   +6 more
europepmc   +1 more source

CORRECTION TO: The Inhibition Mechanism of Pancreatic Ductal Adenocarcinoma via LXR Receptors: A Multifaceted Approach Integrating Molecular Docking, Molecular Dynamics and Post-MD Inter- Molecular Contact Analysis. [PDF]

Asian Pac J Cancer Prev
europepmc   +1 more source