Results 241 to 250 of about 5,491,440 (299)

Unprecedented carbonic anhydrase inhibition mechanism: Targeting histidine 64 side chain through a halogen bond. [PDF]

open access: yesArch Pharm (Weinheim)
Paciotti R   +6 more
europepmc   +1 more source

Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter. [PDF]

open access: yesNat Struct Mol Biol
Hiraizumi M   +7 more
europepmc   +1 more source

In Silico Description of the Direct Inhibition Mechanism of Endothelial Lipase by ANGPTL3. [PDF]

open access: yesInt J Mol Sci
Montavoci L   +8 more
europepmc   +1 more source

Mechanisms of CYP450 Inhibition: Understanding Drug-Drug Interactions Due to Mechanism-Based Inhibition in Clinical Practice

open access: yesPharmaceutics, 2020
In an ageing society, polypharmacy has become a major public health and economic issue. Overuse of medications, especially in patients with chronic diseases, carries major health risks. One common consequence of polypharmacy is the increased emergence of
Veronique Michaud   +2 more
exaly   +2 more sources
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On the mechanism of prepulse inhibition☆

Physiology & Behavior, 1974
Abstract Prepulse inhibition of the acoustic startle response in rats was studied in normal or sham-operated animals or animals with bilateral lesions in the frontal poles, dorsal hippocampus and overlying parietal cortex, parietal cortex alone, or bilateral electrolytic lesions in the motor nuclei of the fifth and seventh cranial nerves which ...
P M, Groves   +3 more
openaire   +2 more sources

Mechanism and Inhibition of Matrix Metalloproteinases

Current Medicinal Chemistry, 2019
Matrix metalloproteinases hydrolyze proteins and glycoproteins forming the extracellular matrix, cytokines and growth factors released in the extracellular space, and membrane-bound receptors on the outer cell membrane. The pathological relevance of MMPs has prompted the structural and functional characterization of these enzymes and the development of
Cerofolini L., Fragai M., Luchinat C.
openaire   +3 more sources

Pepstatin Inhibition Mechanism

1977
Pepstatin is a low molecular weight, potent inhibitor specific for acid proteases with a Ki value of about 10(-10)M for pepsin. The chemical structure of pepstatin is essentially a hexapeptide which contains two residues of an unusual amino acid, 4-amino-3-hydroxy-6-methylheptanoic acid (statine).
J, Marciniszyn, J A, Hartsuck, J, Tang
openaire   +2 more sources

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