Results 261 to 270 of about 5,491,440 (299)
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Mechanisms of inhibition of phospholipase A2
Biochemical Pharmacology, 1980Abstract Differential scanning calorimetry (d.s.c.) and assays of phospholipase A2 activity were used as tools to distinguish between drugs which interact with the phospholipids and those which interact directly with the enzyme. Cholesterol lowered the transition temperature (tc) and reduced the heat absorbed at transition and inhibited phospholipase
C, Vigo, G P, Lewis, P J, Piper
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Mechanism of Inhibition of Ribosomes by Streptomycin
Nature, 1969During streptomycin inhibition of translation of phage mRNA the peptidyl-tRNA is blocked in the ribosome P site. The binding of both aminoacyl-tRNA and peptidyl-tRNA to the ribosomal A site is impaired.
J, Modolell, B D, Davis
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Mechanisms of Inhibition of Tumor Progression
1993Experimental and epidemiologic studies have demonstrated that carcinogenesis is a multistage process that can be divided into three major stages: initiation, promotion, and progression (22). Progression encompasses the changes by which a tumor evolves from a contained, differentiated lesion of uncoordinated growth into a rapidly growing, invasive ...
B S, Warren, T J, Slaga
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Mechanisms of inhibition of insulin release
American Journal of Physiology-Cell Physiology, 1996Several agonists including norepinephrine, somatostatin, galanin, and prostaglandins inhibit insulin releasse. The inhibition is sensitive to pertussis toxin, indicating the involvement of heterotrimeric Gi and/or Go proteins. Receptors for the different agonists have different selectivity for these G proteins.
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A kinetic inhibition mechanism for maintenance
Journal of Theoretical Biology, 2007To fulfil their maintenance costs, most species use mobile pools of metabolites (reserve) in favourable conditions, but can also use less mobile pools (structure) under food-limiting conditions. While some empirical models always pay maintenance costs from structure, the presence of reserve inhibits the use of structure for maintenance purposes.
Tolla, Caroline +2 more
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Neurophysiologic mechanisms of internal inhibition
The Pavlovian Journal of Biological Science, 1983The experimental results obtained in the authors' laboratory as a result of multiple recording of slow biopotentials, the recording of neuronal activity and of mathematical modeling, are reviewed. The authors conclude that the elaboration of internal inhibition is followed, and determined to a great extent, by the restriction in conduction of ...
M N, Livanov, G I, Shulgina
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Mechanisms of monooxygenase induction and inhibition
Pharmacology & Therapeutics, 1987The mechanisms of monooxygenase induction and inhibition have been discussed from the standpoint of historic development, from the current concepts about the molecular mechanism of enzyme induction, and from the various possibilities by which inhibitors can interact with the complex cytochrome P-450 monooxygenase system. In detail the main features and
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Mechanisms of Selenium Inhibition of Tumorigenesis
Journal of the American College of Toxicology, 1986Numerous experiments have demonstrated that selenium supplementation to the diet at modest and nontoxic levels is an effective inhibitor of mammary tumorigenesis in mice and rats. In mice, selenium is most effective during the early stages of tumorigenesis, in particular the events surrounding the induction and expression of the preneoplastic ...
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Mechanism of Inhibition of Glycolysis by Vanadate
1986Vanadate is a well known inhibitor of the Na+, K+-ATPase (1,2). In addition to the effects on the sodium pump, vanadium compounds have been shown to inhibit acid phosphatase, alkaline phosphatase and adenylate kinase (3,4) as well as several of the enzymes in the glycolytic pathway (5), including glyceraldehyde-3-posphate dehydrogenase (6 ...
J E, Benabe +2 more
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Mechanism of inhibition of ribonuclease by bentonite
Canadian Journal of Biochemistry, 1968A study of the mode of inhibition of RNase by bentonite showed that the inactivation of the enzyme could not be attributed solely to an ion-exchange effect as previously postulated. Vermiculite, which is a clay with higher cation capacity than bentonite, showed very little inactivation of RNase.
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