Results 261 to 270 of about 2,456,442 (305)
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A mechanism for inhibition in visual search
2011 45th Annual Conference on Information Sciences and Systems, 2011Observers can use explicit foreknowledge of a feature of an upcoming target to guide search. However, little is known about observers' use of explicit foreknowledge that a specific feature will not match the upcoming target. In a series of experiments, we presented observers with either “ignore” cues that validly indicated the color of a nontarget item
Jeff Moher, Howard E. Egeth
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Mechanism of Inhibition of Glycolysis by Vanadate
1986Vanadate is a well known inhibitor of the Na+, K+-ATPase (1,2). In addition to the effects on the sodium pump, vanadium compounds have been shown to inhibit acid phosphatase, alkaline phosphatase and adenylate kinase (3,4) as well as several of the enzymes in the glycolytic pathway (5), including glyceraldehyde-3-posphate dehydrogenase (6 ...
J E, Benabe +2 more
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Chemistry and Mechanism of Urease Inhibition
Current Medicinal Chemistry, 2002Studies on enzyme inhibition remain an important area of pharmaceutical research since these studies have led to the discoveries of drugs useful in a variety of physiological conditions. The enzyme inhibitors can interact with enzymes and block their activity towards natural substrates.
Z, Amtul +3 more
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On the mechanism of hemolytic plaque inhibition
Immunochemistry, 1974Abstract Equations are presented which and can be used to describe the inhibition of γG plaques by hapten. Two types of experimental situations are considered. In the first the Red Blood Cell epitope density is large enough so that intramolecular reaction is favorable, and the reaction with antibody is considered irreversible during the time of the ...
C, DeLisi, B, Goldstein
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A kinetic inhibition mechanism for maintenance
Journal of Theoretical Biology, 2007To fulfil their maintenance costs, most species use mobile pools of metabolites (reserve) in favourable conditions, but can also use less mobile pools (structure) under food-limiting conditions. While some empirical models always pay maintenance costs from structure, the presence of reserve inhibits the use of structure for maintenance purposes.
Tolla, Caroline +2 more
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Mechanisms of Inhibition of Tumor Progression
1993Experimental and epidemiologic studies have demonstrated that carcinogenesis is a multistage process that can be divided into three major stages: initiation, promotion, and progression (22). Progression encompasses the changes by which a tumor evolves from a contained, differentiated lesion of uncoordinated growth into a rapidly growing, invasive ...
B S, Warren, T J, Slaga
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Mechanisms of Platelet Activation and Inhibition
Hematology/Oncology Clinics of North America, 1990Mechanisms of stimulus-response coupling in platelets are as complex and varied as the compounds that elicit the responses. The complexities are compounded by feedback mechanisms from substances released or synthesized by platelets as well as by "cross-talk" between signal transduction pathways. Examples of cross-talk include the ability of epinephrine
B, Ashby, J L, Daniel, J B, Smith
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Mechanisms of inhibition of insulin release
American Journal of Physiology-Cell Physiology, 1996Several agonists including norepinephrine, somatostatin, galanin, and prostaglandins inhibit insulin releasse. The inhibition is sensitive to pertussis toxin, indicating the involvement of heterotrimeric Gi and/or Go proteins. Receptors for the different agonists have different selectivity for these G proteins.
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Mechanisms of melanogenesis inhibition by propafenone
Archives of Dermatological Research, 2010Melanogenesis is a physiological process that results in the synthesis of melanin pigments, which play a crucial protective role against skin photocarcinogenesis. The present study was conducted to determine the inhibitory effects of propafenone on melanogenesis and to elucidate the molecular events involved in the inhibition of melanogenesis by ...
Sungran, Huh +6 more
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A Specific Mechanism of Nonspecific Inhibition
Journal of Medicinal Chemistry, 2003Promiscuous small molecules plague screening libraries and hit lists. Previous work has found that several nonspecific compounds form submicrometer aggregates, and it has been suggested that this aggregate species is responsible for the inhibition of many different enzymes. It is not understood how aggregates inhibit their targets.
Susan L, McGovern +3 more
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