Results 251 to 260 of about 2,456,442 (305)
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On the mechanism of prepulse inhibition☆
Physiology & Behavior, 1974Abstract Prepulse inhibition of the acoustic startle response in rats was studied in normal or sham-operated animals or animals with bilateral lesions in the frontal poles, dorsal hippocampus and overlying parietal cortex, parietal cortex alone, or bilateral electrolytic lesions in the motor nuclei of the fifth and seventh cranial nerves which ...
P M, Groves +3 more
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Mechanism and Inhibition of Matrix Metalloproteinases
Current Medicinal Chemistry, 2019Matrix metalloproteinases hydrolyze proteins and glycoproteins forming the extracellular matrix, cytokines and growth factors released in the extracellular space, and membrane-bound receptors on the outer cell membrane. The pathological relevance of MMPs has prompted the structural and functional characterization of these enzymes and the development of
Cerofolini L., Fragai M., Luchinat C.
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Inhibition of platelet aggregation by idebenone and the mechanism of the inhibition
Archives of Gerontology and Geriatrics, 1989The inhibitory effect of 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (idebenone) on platelet aggregation was studied in rat and human platelets in vitro, and the mechanism of inhibition was examined in rat platelets. Idebenone inhibited the aggregation induced by collagen and thrombin in washed platelets, and by arachidonate and ADP in ...
M, Suno, Z, Terashita, A, Nagaoka
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Mechanism of Sechenov inhibition
Neuroscience and Behavioral Physiology, 1983The paper defines the discovery made by I. M. Sechenov in 1863, of inhibition of spinal reflexes in a frog produced by stimulation of the thalami optici with a crystal of NaCl -- first finding revealing inhibition in the central nervous system. The question is discussed, what parts of the nervous system participate in this inhibition and, in particular,
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Mechanism and inhibition of BRAF kinase
Current Opinion in Chemical Biology, 2022The role of BRAF in tumor initiation has been established, however, the precise mechanism of autoinhibition has only been illustrated recently by several structural studies. These structures uncovered the basis by which the regulatory domains engage in regulating the activity of BRAF kinase domain, which lead to a more complete picture of the ...
Amber Gunderwala +2 more
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Pepstatin Inhibition Mechanism
1977Pepstatin is a low molecular weight, potent inhibitor specific for acid proteases with a Ki value of about 10(-10)M for pepsin. The chemical structure of pepstatin is essentially a hexapeptide which contains two residues of an unusual amino acid, 4-amino-3-hydroxy-6-methylheptanoic acid (statine).
J, Marciniszyn, J A, Hartsuck, J, Tang
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Mechanisms of Inhibition of Calcification
Clinical Orthopaedics and Related Research, 1989Mineralization processes in the body are controlled by physicochemical and cellular regulation of hydroxyapatite (HA) nucleators and inhibitors. The chemical mechanism of action of HA inhibitors has been studied in vitro using solution pH-stat techniques or Types I and II collagen gel diffusion systems. Three biologically relevant systems are used with
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Metalloproteinase inhibition as a mechanism for the inhibition of angiogenesis
1992Metalloproteinases are a multigene family of metal-dependent enzymes (usually CA+2 or Zn+2) whose activity is considered to be the key rate-limiting step in extracellular matrix degradation. Of the enzyme systems whose activity and control could have significant physiological ramifications, the metalloproteinase family has, in recent years, been shown ...
M A, Moses, R, Langer
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The mechanism of oxidative inhibition of myosin
Biochimica et Biophysica Acta, 19511. 1. Rat myosin preparations were stable at 37° in the absence of substrate, unlike similar preparations made from rabbit muscle by other workers. 2. The ATP'ase activity of such preparations can be inhibited at pH 7.4 by H2O2 and restored by incubation with cysteine. 3. 3. Adrenochrome is about 8 times as powerful an inactivator of myosin
F, DICKENS, G E, GLOCK
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Mechanisms of Arthrogenic Muscle Inhibition
Journal of Sport Rehabilitation, 2022Context: Arthrogenic muscle inhibition (AMI) continues to be a limiting factor in joint rehabilitation as the inability to volitionally activate muscle significantly dampens recovery. New evidence acquired at higher brain centers and in clinical populations continues to reshape our perspective of what AMI is and how to treat it.
Adam S, Lepley, Lindsey K, Lepley
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