Results 251 to 260 of about 5,491,440 (299)
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Inhibition of platelet aggregation by idebenone and the mechanism of the inhibition
Archives of Gerontology and Geriatrics, 1989The inhibitory effect of 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (idebenone) on platelet aggregation was studied in rat and human platelets in vitro, and the mechanism of inhibition was examined in rat platelets. Idebenone inhibited the aggregation induced by collagen and thrombin in washed platelets, and by arachidonate and ADP in ...
M, Suno, Z, Terashita, A, Nagaoka
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Mechanism of Sechenov inhibition
Neuroscience and Behavioral Physiology, 1983The paper defines the discovery made by I. M. Sechenov in 1863, of inhibition of spinal reflexes in a frog produced by stimulation of the thalami optici with a crystal of NaCl -- first finding revealing inhibition in the central nervous system. The question is discussed, what parts of the nervous system participate in this inhibition and, in particular,
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A Specific Mechanism of Nonspecific Inhibition
Journal of Medicinal Chemistry, 2003Promiscuous small molecules plague screening libraries and hit lists. Previous work has found that several nonspecific compounds form submicrometer aggregates, and it has been suggested that this aggregate species is responsible for the inhibition of many different enzymes. It is not understood how aggregates inhibit their targets.
Susan L, McGovern +3 more
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Metalloproteinase inhibition as a mechanism for the inhibition of angiogenesis
1992Metalloproteinases are a multigene family of metal-dependent enzymes (usually CA+2 or Zn+2) whose activity is considered to be the key rate-limiting step in extracellular matrix degradation. Of the enzyme systems whose activity and control could have significant physiological ramifications, the metalloproteinase family has, in recent years, been shown ...
M A, Moses, R, Langer
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Mechanisms of Inhibition of Calcification
Clinical Orthopaedics and Related Research, 1989Mineralization processes in the body are controlled by physicochemical and cellular regulation of hydroxyapatite (HA) nucleators and inhibitors. The chemical mechanism of action of HA inhibitors has been studied in vitro using solution pH-stat techniques or Types I and II collagen gel diffusion systems. Three biologically relevant systems are used with
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The mechanism of oxidative inhibition of myosin
Biochimica et Biophysica Acta, 19511. 1. Rat myosin preparations were stable at 37° in the absence of substrate, unlike similar preparations made from rabbit muscle by other workers. 2. The ATP'ase activity of such preparations can be inhibited at pH 7.4 by H2O2 and restored by incubation with cysteine. 3. 3. Adrenochrome is about 8 times as powerful an inactivator of myosin
F, DICKENS, G E, GLOCK
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Mechanisms of Platelet Activation and Inhibition
Hematology/Oncology Clinics of North America, 1990Mechanisms of stimulus-response coupling in platelets are as complex and varied as the compounds that elicit the responses. The complexities are compounded by feedback mechanisms from substances released or synthesized by platelets as well as by "cross-talk" between signal transduction pathways. Examples of cross-talk include the ability of epinephrine
B, Ashby, J L, Daniel, J B, Smith
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A mechanism for inhibition in visual search
2011 45th Annual Conference on Information Sciences and Systems, 2011Observers can use explicit foreknowledge of a feature of an upcoming target to guide search. However, little is known about observers' use of explicit foreknowledge that a specific feature will not match the upcoming target. In a series of experiments, we presented observers with either “ignore” cues that validly indicated the color of a nontarget item
Jeff Moher, Howard E. Egeth
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Chemistry and Mechanism of Urease Inhibition
Current Medicinal Chemistry, 2002Studies on enzyme inhibition remain an important area of pharmaceutical research since these studies have led to the discoveries of drugs useful in a variety of physiological conditions. The enzyme inhibitors can interact with enzymes and block their activity towards natural substrates.
Z, Amtul +3 more
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Mechanisms of carcinogenesis inhibition by isothiocyanates
Expert Opinion on Investigational Drugs, 2001Epidemiological studies have suggested that frequent consumption of cruciferous vegetables is associated with a decreased risk in various types of cancer. Cruciferous vegetables are commonly consumed foods that contain organosulfur compounds known as isothiocyanates. These compounds are potent inhibitors of chemically induced carcinogenesis in animals.
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