Results 11 to 20 of about 5,057,415 (322)
International Journal of Molecular Sciences, 2021 Tumor necrosis factor alpha (TNF-α) was initially recognized as a factor that causes the necrosis of tumors, but it has been recently identified to have additional important functions as a pathological component of autoimmune diseases. TNF-α binds to two
Dan-in Jang +7 more
semanticscholar +1 more source
Science, 2020 Targeting a key enzyme in SARS-CoV-2 Scientists across the world are working to understand severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19). Zhang et al.
Linlin Zhang +8 more
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Immune Checkpoint Inhibitors in Cancer Therapy
Current Oncology, 2022 The discovery of immune checkpoint proteins such as PD-1/PDL-1 and CTLA-4 represents a significant breakthrough in the field of cancer immunotherapy.
Y. Shiravand +8 more
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Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19
New England Journal of Medicine, 2020 RAAS Inhibitors in Patients with Covid-19 The effects of renin–angiotensin–aldosterone system blockers on angiotensin-converting enzyme 2 levels and activity in humans are uncertain.
M. Vaduganathan +5 more
semanticscholar +1 more source
In situ click chemistry generation of cyclooxygenase-2 inhibitors
Nature Communications, 2017 Cyclooxygenase-2 isozyme is a promising anti-inflammatory drug target, and overexpression of this enzyme is also associated with several cancers and neurodegenerative diseases.
A. Bhardwaj, J. Kaur, M. Wuest, F. Wuest
semanticscholar +1 more source
DNA sequencing with chain-terminating inhibitors.
Proceedings of the National Academy of Sciences of the United States of America, 1977 A new method for determining nucleotide sequences in DNA is described. It is similar to the "plus and minus" method [Sanger, F. & Coulson, A. R. (1975) J. Mol. Biol.
F. Sanger, S. Nicklen, A. Coulson
semanticscholar +1 more source
CDK inhibitors: positive and negative regulators of G1-phase progression.
Genes & Development, 1999 Mitogen-dependent progression through the first gap phase (G1) and initiation of DNA synthesis (S phase) during the mammalian cell division cycle are cooperatively regulated by several classes of cyclin-dependent kinases (CDKs) whose activities are in ...
C. Sherr, James M. Roberts
semanticscholar +1 more source
Emerging therapeutic opportunities for integrin inhibitors
Nature reviews. Drug discovery, 2021 Integrins are cell adhesion and signalling proteins crucial to a wide range of biological functions. Effective marketed treatments have successfully targeted integrins αIIbβ3, α4β7/α4β1 and αLβ2 for cardiovascular diseases, inflammatory bowel disease ...
R. Slack +4 more
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Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors
Science Translational Medicine, 2011 Lung cancers undergo dynamic genetic and histological changes upon developing resistance to EGFR inhibitors. The Shifting Sands of Lung Cancer Lung cancer is the leading cause of death globally and has proven very difficult to treat.
L. Sequist +21 more
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Frontiers in Chemistry, 2019 β-N-acetylhexosaminidases represent an important class of exoglycosidases and have emerged as the promising targets for drug and pesticide discovery. Among these, human O-GlcNAcase (hOGA) has been reported to be closely linked to several diseases such as
Shengqiang Shen +6 more
doaj +1 more source