Results 11 to 20 of about 3,716,801 (336)

Fluorescent Reporters and Biosensors for Probing the Dynamic Behavior of Protein Kinases

open access: yesProteomes, 2015
Probing the dynamic activities of protein kinases in real-time in living cells constitutes a major challenge that requires specific and sensitive tools tailored to meet the particular demands associated with cellular imaging.
Juan A. González-Vera, May C. Morris
doaj   +1 more source

Gibberellin: inhibitor of an inhibitor of...?

open access: yesBioEssays, 1999
Gibberellin is an endogenous plant growth regulator. Here, we describe our present understanding of how gibberellin regulates plant growth, using recent results gained from studies of gibberellin-signalling mutants of Arabidopsis. These results show that a signalling pathway represses plant growth and that gibberellin releases this repression.
Harberd, N   +5 more
openaire   +4 more sources

Identification of three stage-specific proteinases of Plasmodium falciparum. [PDF]

open access: yes, 1987
We have identified and characterized three stage-specific proteinases of Plasmodium falciparum that are active at neutral pH. We analyzed ring-, trophozoite-, schizont-, and merozoite-stage parasites by gelatin substrate PAGE and characterized the ...
Kim, K   +3 more
core   +2 more sources

Anticancer Inhibitors

open access: yesMolecules, 2022
Cancer is a multifactorial disorder caused by several aberrations in gene expression that generate a homeostatic imbalance between cell division and death [...]
Alessandra Ammazzalorso   +1 more
openaire   +3 more sources

PCSK9 inhibitors

open access: yesSwiss Medical Weekly, 2015
The discovery of proprotein convertase subtilisin kexin 9 (PCSK9) has considerably changed the therapeutic options in the field of lipid management. PCSK9 reduces LDL receptor recycling, leading to a decrease of low-density lipoprotein cholesterol (LDL-C) receptors on the surface of hepatocytes and a subsequent increase of circulating LDL-C levels.
Gencer, B   +2 more
openaire   +6 more sources

Potential role of immunotherapy in advanced non-small-cell lung cancer [PDF]

open access: yes, 2016
Immuno checkpoint inhibitors have ushered in a new era with respect to the treatment of advanced non-small-cell lung cancer. Many patients are not suitable for treatment with epidermal growth factor receptor tyrosine kinase inhibitors (eg, gefitinib ...
Antoniou, Georgios   +4 more
core   +3 more sources

Phosphodiesterase inhibitors [PDF]

open access: yesBritish Journal of Pharmacology, 2006
Phosphodiesterases are a diverse family of enzymes that hydrolyse cyclic nucleotides and thus play a key role in regulating intracellular levels of the second messengers cAMP and cGMP, and hence cell function. Theophylline and papaverine have historically been used therapeutically and are known to be weak inhibitors of PDE, but to what extent this ...
Boswell-Smith, V, Spina, D, Page, C P
openaire   +4 more sources

Computational Drug Repurposing Resources and Approaches for Discovering Novel Antifungal Drugs against Candida albicans N-Myristoyl Transferase

open access: yesJournal of Pure and Applied Microbiology, 2021
Candida albicans is a yeast that is an opportunistic fungal pathogen and also identified as ubiquitous polymorphic species that is mainly linked with major fungal infections in humans, particularly in the immunocompromised patients including transplant ...
Afzal Hussain, Chandan Kumar Verma
doaj   +1 more source

Novel bi- and trifunctional inhibitors of tumor-associated proteolytic systems [PDF]

open access: yes, 2003
Serine proteases, cysteine proteases, and matrix metalloproteinases (MMPs) are involved in cancer cell invasion and metastasis. Recently, a recombinant bifunctional inhibitor (chCysuPA(19-31)) directed against cysteine proteases and the urokinasetype ...
Brew K.   +11 more
core   +2 more sources

Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication

open access: yesViruses, 2015
The current outbreak of Ebola virus (EBOV) in West Africa has claimed the lives of more than 15,000 people and highlights an urgent need for therapeutics capable of preventing virus replication.
Olivier Reynard   +5 more
doaj   +1 more source

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