Results 21 to 30 of about 3,716,801 (336)

Trypsin inhibition by macrocyclic and open-chain variants of the squash inhibitor MCoTI-II [PDF]

, 2005
MCoTl-I and MCoTl-II from the seeds of Momordica cochinchinensis are inhibitors of trypsin-like proteases and the only known members of the large family of squash inhibitors that are cyclic and contain an additional loop connecting the amino- and the ...
Avrutina, Olga, Diederichsen, Ulf, Gabrijelcic-Geiger, Dusica, Kolmar, Harald, Le Nguyen, Dung, Schmoldt, Hans-Ulrich, Sommerhoff, Christian P.   +6 more
core   +1 more source

A comparative evaluation of NB30, NB54 and PTC124 in translational read‐through efficacy for treatment of an USH1C nonsense mutation

EMBO Molecular Medicine, 2012
Translational read‐through‐inducing drugs (TRIDs) promote read‐through of nonsense mutations, placing them in the spotlight of current gene‐based therapeutic research.
Tobias Goldmann, Nora Overlack, Fabian Möller, Valery Belakhov, Michiel van Wyk, Timor Baasov, Uwe Wolfrum, Kerstin Nagel‐Wolfrum   +7 more
doaj   +1 more source

Selective inhibition of carotenoid cleavage dioxygenases : phenotypic effects on shoot branching [PDF]

, 2009
Members of the carotenoid cleavage dioxygenase family catalyse the oxidative cleavage of carotenoids at various chain positions, leading to the formation of a wide range of apocarotenoid signalling molecules.
Akiyama, Alder, Alija, Armstrong, Auldridge, Bennett, Bergeron, Booker, Booker, Borowski, Bouvier, Bouvier, Burbidge, Chatfield, Cunningham, Cunningham, Dudareva, Eisner, Fester, Gomez-Roldan, Han, Han, Hu, Juttner, Kaschani, Kawase, Kiefer, Kitahata, Kloer, Kontogiorgis, Marasco, Matusova, Paik, Quinlan, Scherzinger, Schmidt, Schwartz, Schwartz, Schwartz, Simkin, Sorefan, Stockwell, Suzuki, Taylor, Umehara, Vogel, von Lintig, Walter, Ward, Wilson, Wyss, Yeh, Zeevaart   +52 more
core   +2 more sources

Design and Optimization of Thioglycosyl–naphthalimides as Efficient Inhibitors Against Human O-GlcNAcase

Frontiers in Chemistry, 2019
β-N-acetylhexosaminidases represent an important class of exoglycosidases and have emerged as the promising targets for drug and pesticide discovery. Among these, human O-GlcNAcase (hOGA) has been reported to be closely linked to several diseases such as
Shengqiang Shen, Lili Dong, Wei Chen, Renjie Wu, Huizhe Lu, Qing Yang, Jianjun Zhang   +6 more
doaj   +1 more source

Change of Mechanical Properties of Polyethylene Film Materials during Their Modification by Technological Applications and during Aging

Фізика і хімія твердого тіла, 2020
Mechanical tests and studies of the structure of modified polyethylene film materials used as packaging elements of electronic devices have been carried out.
N. I. Domantsevich, B. P. Yatsushyn
doaj   +1 more source

Glycogen Synthase Kinase 3β Modulates the Inflammatory Response Activated by Bacteria, Viruses, and Parasites

Frontiers in Immunology, 2021
Knowledge of glycogen synthase kinase 3β (GSK3β) activity and the molecules identified that regulate its function in infections caused by pathogenic microorganisms is crucial to understanding how the intensity of the inflammatory response can be ...
Ricarda Cortés-Vieyra, Octavio Silva-García, Anel Gómez-García, Sergio Gutiérrez-Castellanos, Cleto Álvarez-Aguilar, Víctor M. Baizabal-Aguirre   +5 more
doaj   +1 more source

Therapeutic efficacy and safety of ACE inhibitors in the hypertensive paediatric population: a review [PDF]

, 2016
Purpose: Since 1997, strong incentives have been introduced worldwide to improve access to safe and effective medicines addressing the therapeutic needs of children. ACE inhibitors, the most prescribed antihypertensive drugs in the paediatric population,
De Bruyne, Pauline, Snauwaert, Evelien, Vande Walle, Johan   +2 more
core   +3 more sources

GDP-Mannose Pyrophosphorylase: A Biologically Validated Target for Drug Development Against Leishmaniasis

Frontiers in Cellular and Infection Microbiology, 2019
Leishmaniases are neglected tropical diseases that threaten about 350 million people in 98 countries around the world. In order to find new antileishmanial drugs, an original approach consists in reducing the pathogenic effect of the parasite by ...
Sébastien Pomel, Wei Mao, Tâp Ha-Duong, Christian Cavé, Philippe M. Loiseau   +4 more
doaj   +1 more source

Novel Insight into the in vivo Function of Mast Cell Chymase: Lessons from Knockouts and Inhibitors

Journal of Innate Immunity, 2020
Mast cells are now recognized as key players in diverse pathologies, but the mechanisms by which they contribute in such settings are only partially understood.
Gunnar Pejler
doaj   +1 more source

Co-targeting HGF/cMET Signaling with MEK Inhibitors in Metastatic Uveal Melanoma. [PDF]

, 2017
Patients with metastatic uveal melanoma usually die within 1 year of diagnosis, emphasizing an urgent need to develop new treatment strategies. The liver is the most common site of metastasis.
Aplin, Andrew E., Cheng, Hanyin, Chua, Vivian, Davies, Michael A., Kageyama, Ken, Liao, Connie, Purwin, Timothy J., Sato, Takami, Terai, Mizue   +8 more
core   +2 more sources