Results 21 to 30 of about 5,333,350 (348)
Review of PD-1/PD-L1 Inhibitors in Metastatic dMMR/MSI-H Colorectal Cancer
Frontiers in Oncology, 2019 There are a wide range of therapies for metastatic colorectal cancer (CRC) available, but outcomes remain suboptimal. Learning the role of the immune system in cancer development and progression led to advances in the treatment over the last decade ...
André F. Oliveira +2 more
doaj +1 more source
A decade of immune-checkpoint inhibitors in cancer therapy
Nature Communications, 2020 Immunotherapy using immune-checkpoint modulators revolutionizes the oncology field far beyond their remarkable clinical efficacy in some patients. It creates radical changes in the evaluation of treatment efficacy and toxicity with a more holistic vision
C. Robert
semanticscholar +1 more source
Japanese Journal of Clinical Immunology, 2013 Non-receptor type of protein-tyrosine kinase Syk (spleen tyrosine kinase) was isolated in University of Fukui in 1991. Syk is most highly expressed by haemopoietic cells and known to play crucial roles in the signal transduction through various immunoreceptors of the adaptive immune response.
Kazuyasu, Chihara +4 more
openaire +3 more sources
EMBO Molecular Medicine, 2012 Translational read‐through‐inducing drugs (TRIDs) promote read‐through of nonsense mutations, placing them in the spotlight of current gene‐based therapeutic research.
Tobias Goldmann +7 more
doaj +1 more source
Frontiers in Microbiology, 2019 We report the successful implementation of virtual screening in the discovery of new inhibitors of undecaprenyl pyrophosphate synthase (UppS) from Escherichia coli. UppS is an essential enzyme in the biosynthesis of bacterial cell wall.
Marko Jukič +4 more
doaj +1 more source
Frontiers in Chemistry, 2022 Activated Cdc42-associated kinase 1 (ACK1/TNK2) has a significant role in cell endocytosis, survival, proliferation, and migration. Mutations in ACK1 are closely associated with the occurrence and development of cancers.
Ruby Srivastava
doaj +1 more source
Hereditary Cancer in Clinical Practice, 2015 بوليميرازات بولي (ADP - ريبوز)، التي يتم اختصارها باسم PARPs، هي مجموعة من البروتينات المألوفة التي تلعب دورًا مركزيًا في إصلاح الحمض النووي باستخدام مسار إصلاح استئصال القاعدة (BER). هناك حوالي 17 بروتينًا في هذه العائلة منها PARPs النووية الأولية هي PARP -1 و PARP -2 و PARP -3 و tankyrases 1 و 2 (PARP -5a و -5b).
Maheen Anwar +2 more
openaire +2 more sources
Research Progress of Squalene Monooxygenase and Cancer
Zhongliu Fangzhi Yanjiu, 2023 Squalene monooxygenase (SQLE) is the rate-limiting enzyme of cholesterol biosynthesis. It plays a crucial role in regulating cholesterol homeostasis. Increasing evidence shows that SQLE is closely related to the occurrence, development, metastasis, and ...
GUO Liangqi, LIU Yayun, SHENG Deqiao
doaj +1 more source
FGF19–FGFR4 Signaling in Hepatocellular Carcinoma
Cells, 2019 Hepatocellular carcinoma (HCC) is the sixth most common type of cancer, with an increasing mortality rate. Aberrant expression of fibroblast growth factor 19−fibroblast growth factor receptor 4 (FGF19−FGFR4) is reported to be an oncogenic ...
Aroosha Raja +3 more
doaj +1 more source
Corrosion Inhibitors: Natural and Synthetic Organic Inhibitors
Lubricants, 2023 Corrosion is a major challenge in various industries and can cause significant damage to metal structures. Organic corrosion inhibitors are compounds that are used to reduce or prevent corrosion by forming a protective film on metal surfaces. The present
Ahmed A. Al-amiery +2 more
semanticscholar +1 more source