Results 21 to 30 of about 5,057,415 (322)
Фізика і хімія твердого тіла, 2020 Mechanical tests and studies of the structure of modified polyethylene film materials used as packaging elements of electronic devices have been carried out.
N. I. Domantsevich, B. P. Yatsushyn
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Frontiers in Immunology, 2021 Knowledge of glycogen synthase kinase 3β (GSK3β) activity and the molecules identified that regulate its function in infections caused by pathogenic microorganisms is crucial to understanding how the intensity of the inflammatory response can be ...
Ricarda Cortés-Vieyra +5 more
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Frontiers in Cellular and Infection Microbiology, 2019 Leishmaniases are neglected tropical diseases that threaten about 350 million people in 98 countries around the world. In order to find new antileishmanial drugs, an original approach consists in reducing the pathogenic effect of the parasite by ...
Sébastien Pomel +4 more
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Novel Insight into the in vivo Function of Mast Cell Chymase: Lessons from Knockouts and Inhibitors
Journal of Innate Immunity, 2020 Mast cells are now recognized as key players in diverse pathologies, but the mechanisms by which they contribute in such settings are only partially understood.
Gunnar Pejler
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PARP inhibitors: Synthetic lethality in the clinic
Science, 2017 PARP inhibitors (PARPi), a cancer therapy targeting poly(ADP-ribose) polymerase, are the first clinically approved drugs designed to exploit synthetic lethality, a genetic concept proposed nearly a century ago.
C. Lord, A. Ashworth
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Química Nova, 2009 The development and characterization of bioreactors or IMER (immobilized enzyme reactors) as research tools are important in the scope of medicinal chemistry and constitute an alternative for the rational development of drugs.
Carmen Lúcia Cardoso +2 more
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The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases
International Journal of Molecular Sciences, 2020 Matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular matrix (ECM) remodeling endopeptidases that have the capacity to degrade almost every component of the ECM.
Griselda A. Cabral-Pacheco +7 more
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The Development of CK2 Inhibitors: From Traditional Pharmacology to in Silico Rational Drug Design
Pharmaceuticals, 2017 Casein kinase II (CK2) is an ubiquitous and pleiotropic serine/threonine protein kinase able to phosphorylate hundreds of substrates. Being implicated in several human diseases, from neurodegeneration to cancer, the biological roles of CK2 have been ...
Giorgio Cozza
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Science Advances, 2019 Gingipains from Porphyromonas gingivalis drive Alzheimer’s pathology and can be blocked with small-molecule inhibitors. Porphyromonas gingivalis, the keystone pathogen in chronic periodontitis, was identified in the brain of Alzheimer’s disease patients.
S. Dominy +25 more
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A decade of immune-checkpoint inhibitors in cancer therapy
Nature Communications, 2020 Immunotherapy using immune-checkpoint modulators revolutionizes the oncology field far beyond their remarkable clinical efficacy in some patients. It creates radical changes in the evaluation of treatment efficacy and toxicity with a more holistic vision
C. Robert
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