Results 21 to 30 of about 6,774,149 (386)
The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases
International Journal of Molecular Sciences, 2020 Matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular matrix (ECM) remodeling endopeptidases that have the capacity to degrade almost every component of the ECM.
Griselda A. Cabral-Pacheco +7 more
semanticscholar +1 more source
Immune Checkpoint Inhibitors in Cancer Therapy
Current Oncology, 2022 The discovery of immune checkpoint proteins such as PD-1/PDL-1 and CTLA-4 represents a significant breakthrough in the field of cancer immunotherapy.
Y. Shiravand +8 more
semanticscholar +1 more source
Trypsin inhibition by macrocyclic and open-chain variants of the squash inhibitor MCoTI-II [PDF]
, 2005 MCoTl-I and MCoTl-II from the seeds of Momordica cochinchinensis are inhibitors of trypsin-like proteases and the only known members of the large family of squash inhibitors that are cyclic and contain an additional loop connecting the amino- and the ...
Avrutina, Olga +6 more
core +1 more source
Swiss Medical Weekly, 2015 The discovery of proprotein convertase subtilisin kexin 9 (PCSK9) has considerably changed the therapeutic options in the field of lipid management. PCSK9 reduces LDL receptor recycling, leading to a decrease of low-density lipoprotein cholesterol (LDL-C) receptors on the surface of hepatocytes and a subsequent increase of circulating LDL-C levels.
Gencer, B +2 more
openaire +6 more sources
Pharmaceutical Patent Analyst, 2012 PDK1 is a key member of the AGC protein kinase family. It plays an important role in a variety of cellular functions, leading to the activation of the PI3K signaling pathway, an event often associated with the onset and progression of several human cancers.
Elisa, Barile +2 more
openaire +2 more sources
CDK inhibitors: positive and negative regulators of G1-phase progression.
Genes & Development, 1999 Mitogen-dependent progression through the first gap phase (G1) and initiation of DNA synthesis (S phase) during the mammalian cell division cycle are cooperatively regulated by several classes of cyclin-dependent kinases (CDKs) whose activities are in ...
C. Sherr, James M. Roberts
semanticscholar +1 more source
Multifunctional Donepezil Analogues as Cholinesterase and BACE1 Inhibitors
Molecules, 2018 A series of 22 donepezil analogues were synthesized through alkylation/benzylation and compared to donepezil and its 6-O-desmethyl adduct. All the compounds were found to be potent inhibitors of both acetylcholinesterase (AChE) and butyrylcholinesterase (
Keith D. Green +2 more
doaj +1 more source
Review of PD-1/PD-L1 Inhibitors in Metastatic dMMR/MSI-H Colorectal Cancer
Frontiers in Oncology, 2019 There are a wide range of therapies for metastatic colorectal cancer (CRC) available, but outcomes remain suboptimal. Learning the role of the immune system in cancer development and progression led to advances in the treatment over the last decade ...
André F. Oliveira +2 more
doaj +1 more source
Japanese Journal of Clinical Immunology, 2013 Non-receptor type of protein-tyrosine kinase Syk (spleen tyrosine kinase) was isolated in University of Fukui in 1991. Syk is most highly expressed by haemopoietic cells and known to play crucial roles in the signal transduction through various immunoreceptors of the adaptive immune response.
Kazuyasu, Chihara +4 more
openaire +3 more sources
EMBO Molecular Medicine, 2012 Translational read‐through‐inducing drugs (TRIDs) promote read‐through of nonsense mutations, placing them in the spotlight of current gene‐based therapeutic research.
Tobias Goldmann +7 more
doaj +1 more source