Results 271 to 280 of about 753,617 (295)

Lopinavir concentrations in cerebrospinal fluid exceed the 50% inhibitory concentration for HIV

AIDS, 2005
Lopinavir (LPV) is highly bound to plasma proteins and is a substrate for active drugs transporters, which may greatly limit the access of LPV to the central nervous system (CNS). However, even low lopinavir concentrations may be sufficient to inhibit HIV replication.
Edmund V, Capparelli, Diane, Holland, Charles, Okamoto, Bryan, Gragg, Janis, Durelle, Jennifer, Marquie-Beck, Geoffrey, van den Brande, Ron, Ellis, Scott, Letendre   +8 more
openaire   +2 more sources

Mutations in the 50S ribosomal subunit of Brachyspira hyodysenteriae associated with altered minimum inhibitory concentrations of pleuromutilins

Veterinary Microbiology, 2014
Brachyspira hyodysenteriae, the causative agent of swine dysentery, is responsible for severe mucohaemorrhagic colitis with considerable financial loss to worldwide swine production. Antimicrobial resistance against macrolides and lincosamides is widespread and the mechanisms are well known.
Sonja, Hillen, Hermann, Willems, Werner, Herbst, Judith, Rohde, Gerald, Reiner   +4 more
openaire   +2 more sources

Development of Quantum Chemical Method to Calculate Half Maximal Inhibitory Concentration (IC₅₀)

Molecular Informatics, 2016
AbstractTill date theoretical calculation of the half maximal inhibitory concentration (IC50 ) of a compound is based on different Quantitative Structure Activity Relationship (QSAR) models which are empirical methods. By using the Cheng‐Prusoff equation it may be possible to compute IC50, but this will be computationally very expensive as it requires ...
Arijit, Bag, Pradip Kr, Ghorai
openaire   +2 more sources

In vitro efficacy of chemotherapeutics as determined by 50% inhibitory concentrations in cell cultures of mammary gland tumors obtained from dogs

American Journal of Veterinary Research, 2001
Abstract Objective—To determine the 50% inhibitory concentration (IC-50) of carboplatin, cisplatin, and doxorubicin in cell cultures of mammary gland tumors obtained from dogs and to assess whether in vitro efficacy was within the range of clinically relevant concentrations.
D, Simon, J W, Knebel, W, Baumgartner, M, Aufderheide, A, Meyer-Lindenberg, I, Nolte   +5 more
openaire   +2 more sources

Nonlinear concentration gradients regulated by the width of channels for observation of half maximal inhibitory concentration (IC₅₀) of transporter proteins

The Analyst, 2015
We determine a probable IC50 value of ABC transporter proteins by using a width-modulated nonlinear concentration gradient generator.
Yuta, Abe, Koki, Kamiya, Toshihisa, Osaki, Hirotaka, Sasaki, Ryuji, Kawano, Norihisa, Miki, Shoji, Takeuchi   +6 more
openaire   +2 more sources

Personalized adjuvant chemotherapy for colorectal cancer based on an individual 50% inhibitory area under the concentration curve using collagen gel droplet embedded culture-drug sensitivity test.

Journal of Clinical Oncology, 2010
3582 Background: Tumor cell drug sensitivity is important in developing personalized chemotherapy.
T. Ochiai, K. Nishimura, T. Watanabe, M. Kitajima, T. Hashiguchi, A. Nakatani, A. Muraki, N. Sakuyama, S. Futagawa, I. Nagaoka   +9 more
openaire   +1 more source

BCR–ABL activity measured by 50% inhibitory concentration for imatinib, p-CrkL/CrkL ratio or p-CrkL ratio in CD34+ cells of patients with chronic myeloid leukemia does not predict treatment response

Leukemia & Lymphoma, 2012
In this study, we assessed BCR-ABL kinase activity by measuring the protein levels of CrkL and its phosphorylated form (p-CrkL) in order to predict the clinical outcome of newly diagnosed chronic myeloid leukemia patients. CD34+ cells from these patients were collected before the start of imatinib therapy and treated in vitro with imatinib.
Pavel, Simara, Martina, Peterkova, Stanislav, Stejskal, Michaela, Potesilova, Irena, Koutna, Zdenek, Racil, Filip, Razga, Tomas, Jurcek, Dana, Dvorakova, Jiri, Mayer   +9 more
openaire   +2 more sources

Quantitating immunosuppression. Estimating the 50% inhibitory concentration for in vivo cyclosporine in mice.

Transplantation, 1996
Cyclosporine (CsA) blocks T cell responses in vitro by inhibiting the phosphatase activity of calcineurin (CN) and thus preventing the activation of cytokine transcription. In the study presented here, we measured the extent of inhibition of these functions in the tissues of CsA-fed mice. Mice fed increasing doses of CsA were assessed for CsA blood and
T D, Batiuk, J, Urmson, D, Vincent, R W, Yatscoff, P F, Halloran   +4 more
openaire   +1 more source

[Comparison of light-scattering index 50% (LSI50) and inhibitory concentration 50% (CI50) (author's transl)].

Annales de microbiologie, 1982
The "Autobac" apparatus permitted the rapid determination of the light-scattering index 50% (LSI50) and inhibitory concentration 50% (CI50) of eight antibiotics -- kanamycin, amikacin, lividomycin, gentamicin, tobramycin, sisomicin, netilmicin and colistin -- for the strain of Escherichia coli ATCC-25922.
S S, Chung, H B, Drugeon, A, Reynaud, A L, Courtieu   +3 more
openaire   +1 more source

A study for establishment of individualized chemotherapy for colorectal cancer based on the individual 50% inhibitory area under the concentration curve (AUC_IR50) using the collagen gel droplet embedded culture-drug sensitivity test (CD- DST)

Journal of Clinical Oncology, 2007
14553 Background: The drug sensitivity of tumor cells is one of the key issues to explore in individualized 5-fluorouracil (5-FU) based chemotherapy for colorectal cancer patients. We reported that growth inhibition rate (IR) and area under the concentration curve (AUC) approximated to a logarithmic curve using the collagen gel droplet embedded ...
T. Ochiai, K. Nishimura, T. Watanabe, M. Kitajima, N. Konishi, G. Sato, S. Futagawa, I. Nagaoka   +7 more
openaire   +1 more source