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Ethnopharmacological insights into type 2 diabetes management by traditional Moroccan herbal teas: HPLC-MS characterization of phenolic compounds and their related antioxidant and enzyme inhibitory activities. [PDF]

BMC Complement Med Ther
Zayed A, El Jemli M, Kharbach M, Faouzi MEA, Radwan RA, Ezzat SM.   +5 more
europepmc   +1 more source

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Lopinavir concentrations in cerebrospinal fluid exceed the 50% inhibitory concentration for HIV

AIDS, 2005
Lopinavir (LPV) is highly bound to plasma proteins and is a substrate for active drugs transporters, which may greatly limit the access of LPV to the central nervous system (CNS). However, even low lopinavir concentrations may be sufficient to inhibit HIV replication.
Edmund V, Capparelli, Diane, Holland, Charles, Okamoto, Bryan, Gragg, Janis, Durelle, Jennifer, Marquie-Beck, Geoffrey, van den Brande, Ron, Ellis, Scott, Letendre   +8 more
openaire   +2 more sources

Mutations in the 50S ribosomal subunit of Brachyspira hyodysenteriae associated with altered minimum inhibitory concentrations of pleuromutilins

Veterinary Microbiology, 2014
Brachyspira hyodysenteriae, the causative agent of swine dysentery, is responsible for severe mucohaemorrhagic colitis with considerable financial loss to worldwide swine production. Antimicrobial resistance against macrolides and lincosamides is widespread and the mechanisms are well known.
Sonja, Hillen, Hermann, Willems, Werner, Herbst, Judith, Rohde, Gerald, Reiner   +4 more
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Development of Quantum Chemical Method to Calculate Half Maximal Inhibitory Concentration (IC₅₀)

Molecular Informatics, 2016
AbstractTill date theoretical calculation of the half maximal inhibitory concentration (IC50 ) of a compound is based on different Quantitative Structure Activity Relationship (QSAR) models which are empirical methods. By using the Cheng‐Prusoff equation it may be possible to compute IC50, but this will be computationally very expensive as it requires ...
Arijit, Bag, Pradip Kr, Ghorai
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In vitro efficacy of chemotherapeutics as determined by 50% inhibitory concentrations in cell cultures of mammary gland tumors obtained from dogs

American Journal of Veterinary Research, 2001
Abstract Objective—To determine the 50% inhibitory concentration (IC-50) of carboplatin, cisplatin, and doxorubicin in cell cultures of mammary gland tumors obtained from dogs and to assess whether in vitro efficacy was within the range of clinically relevant concentrations.
D, Simon, J W, Knebel, W, Baumgartner, M, Aufderheide, A, Meyer-Lindenberg, I, Nolte   +5 more
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Nonlinear concentration gradients regulated by the width of channels for observation of half maximal inhibitory concentration (IC ₅₀ ) of transporter proteins

The Analyst, 2015
We determine a probable IC 50 value of ABC transporter proteins by using a width-modulated nonlinear concentration gradient generator.
Yuta, Abe, Koki, Kamiya, Toshihisa, Osaki, Hirotaka, Sasaki, Ryuji, Kawano, Norihisa, Miki, Shoji, Takeuchi   +6 more
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Personalized adjuvant chemotherapy for colorectal cancer based on an individual 50% inhibitory area under the concentration curve using collagen gel droplet embedded culture-drug sensitivity test.

Journal of Clinical Oncology, 2010
3582 Background: Tumor cell drug sensitivity is important in developing personalized chemotherapy.
T. Ochiai, K. Nishimura, T. Watanabe, M. Kitajima, T. Hashiguchi, A. Nakatani, A. Muraki, N. Sakuyama, S. Futagawa, I. Nagaoka   +9 more
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