Results 111 to 120 of about 299,758 (277)

Disinhibition, an emerging pharmacology of learning and memory [version 1; referees: 3 approved]

F1000Research, 2017
Learning and memory are dependent on interactive excitatory and inhibitory mechanisms. In this review, we discuss a mechanism called disinhibition, which is the release of an inhibitory constraint that effectively results in an increased activity in the ...
Hanns Möhler, Uwe Rudolph
doaj   +1 more source

A dynamical model of C. elegans thermal preference reveals independent excitatory and inhibitory learning pathways. [PDF]

Proc Natl Acad Sci U S A, 2023
Roman A, Palanski K, Nemenman I, Ryu WS.
europepmc   +1 more source

Optimization of the Production of Rubber Compounds Using Mathematical Models

Advanced Engineering Materials, EarlyView.
Rubber compounds were mixed in a batch internal mixer, and symbolic regression was used to derive mathematical models linking recipe and process parameters to ram path, torque, and mixing quality (incorporation, dispersion, distribution). Subsequent optimization with evolutionary algorithms identified operating conditions that reduce specific energy ...
Anke Bardehle, Andreas Limper, Ulrich Giese, Carlos Lucke, Mario Beiner, Christoph Gögelein, Lisa Leuchtenberger‐Engel, Christian Hopmann   +7 more
wiley   +1 more source

Mining Bovine Milk Proteins for DPP-4 Inhibitory Peptides Using Machine Learning and Virtual Proteolysis

Research
Dipeptidyl peptidase-IV (DPP-4) enzyme inhibitors are a promising category of diabetes medications. Bioactive peptides, particularly those derived from bovine milk proteins, play crucial roles in inhibiting the DPP-4 enzyme.
Yiyun Zhang, Yiqing Zhu, Xin Bao, Zijian Dai, Qun Shen, Liyang Wang, Yong Xue   +6 more
doaj   +1 more source

Reinforcement rate and the balance between excitatory and inhibitory learning: Insights from deletion of the GluA1 AMPA receptor subunit. [PDF]

J Exp Psychol Anim Learn Cogn, 2022
Austen JM, Sprengel R, Sanderson DJ.
europepmc   +1 more source

Stretching the Printability Metric in Direct‐Ink Writing with Highly Extensible Yield‐Stress Fluids

Advanced Functional Materials, EarlyView.
This study introduces “drawability” as a new metric for assessing printability in direct‐ink writing, focusing on gap‐spanning performance and speed robustness. By designing yield‐stress fluids with high extensibility, we demonstrate that extensional strain‐to‐break significantly enhances printability.
Chaimongkol Saengow, Samya Sen, Joaquin Yus, Eliza E. Lovrich, Amanda G. Hoika, Kelly M. Chang, Arielle A. Pfeil, Nellie Haug, Amy J. Wagoner Johnson, Randy H. Ewoldt   +9 more
wiley   +1 more source

A novel bioinformatics pipeline for the identification of immune inhibitory receptors as potential therapeutic targets

eLife
Despite major successes with inhibitory receptor blockade in cancer, the identification of novel inhibitory receptors as putative drug targets is needed due to lack of durable responses, therapy resistance, and side effects.
Akashdip Singh, Alberto Miranda Bedate, Helen J von Richthofen, Saskia V Vijver, Michiel van der Vlist, Raphael Kuhn, Alexander Yermanos, Jürgen J Kuball, Can Kesmir, M Ines Pascoal Ramos, Linde Meyaard   +10 more
doaj   +1 more source

Serotonin 1B receptor effects on response inhibition are independent of inhibitory learning. [PDF]

Neurobiol Learn Mem, 2022
Desrochers SS, Nautiyal KM.
europepmc   +1 more source

Anticipatory Semantic Processes [PDF]

, 2000
Why anticipatory processes correspond to cognitive abilities of living systems? To be adapted to an environment, behaviors need at least i) internal representations of events occurring in the external environment; and ii) internal anticipations of ...
Frédéric Lavigne, Pascal Lavigne, Sophia Antipolis, Université Nice   +3 more
core   +2 more sources

Auto‐Generated Valence States in Electrocatalysts for Boosting Oxygen and Hydrogen Evolution Kinetics in Alkaline Water/Alkaline Seawater/Simulated Seawater/Natural Seawater

Advanced Functional Materials, EarlyView.
This review systematically highlights the latest achievements in mixed‐valence states relevant to hydrogen and oxygen evolution reactions, providing essential insights into future directions and methods for large‐scale practical implementation. This critical review is expected to provide an overview of recent advancements in diverse valence‐state metal
Jitendra N. Tiwari, Gokul Bhaskaran, Krishan Kumar, Yun Suk Huh, Young‐Kyu Han   +4 more
wiley   +1 more source