Results 91 to 100 of about 1,294,563 (307)

From Hiring to Firing: Activation of Inhibitory Neurons and Their Recruitment in Behavior

Frontiers in Molecular Neuroscience, 2019
The investigation of GABAergic inhibitory circuits has substantially expanded over the past few years. The development of new tools and technology has allowed investigators to classify many diverse groups of inhibitory neurons by several delineating ...
Olivia K. Swanson, Olivia K. Swanson, Arianna Maffei, Arianna Maffei   +3 more
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Subregion-specific input organization of prefrontal-projecting basal forebrain cholinergic neurons and weakened striatal–NBM inhibitory transmission in 5xFAD mice

Neurobiology of Disease
Basal forebrain cholinergic neurons regulate cortical activity and cognition and are vulnerable in Alzheimer’s disease (AD). However, the upstream circuits controlling projection-defined basal forebrain cholinergic populations remain incompletely ...
Yufei Huang, Xueyi Xie, Michael Fernaine, Ziyi Li, Xuehua Wang, Jun Wang   +5 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Excitatory neurons are strongly tuned; inhibitory neurons are poorly tuned.

, 2014
Tuning properties of excitatory and inhibitory neurons. (A) Representative tuning curves for 3 excitatory (red, 1-3) and 3 inhibitory (blue, 4-6) neurons in a WTA network after the learning process.
Rodney J. Douglas (157678), Dylan R. Muir (669531), Andreas Hauri (444466), Michael Pfeiffer (320212), Frédéric Zubler (3270735), Roman Bauer (446116), Sabina Pfister (446115)   +6 more
core   +1 more source

Adolescent maturation of inhibitory inputs onto cingulate cortex neurons is cell-type specific and TrkB dependent

Frontiers in Neural Circuits, 2015
The maturation of inhibitory circuits during adolescence may be tied to the onset of mental health disorders such as schizophrenia. Neurotrophin signaling likely plays a critical role in supporting inhibitory circuit development and is also implicated in
Angela eVandenberg, David J. Piekarski, Natalia eCaporale, Francisco Javier eMunoz-Cuevas, Linda eWilbrecht   +4 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Laminar specificity and coverage of viral-mediated gene expression restricted to GABAergic interneurons and their parvalbumin subclass in marmoset primary visual cortex

eLife
In the mammalian neocortex, inhibition is important for dynamically balancing excitation and shaping the response properties of cells and circuits. The various computational functions of inhibition are thought to be mediated by different inhibitory ...
Frederick Federer, Justin Balsor, Alexander Ingold, David P Babcock, Jordane Dimidschstein, Alessandra Angelucci   +5 more
doaj   +1 more source

The Origin of Neocortical Nitric Oxide Synthase-expressing Neurons

Frontiers in Neural Circuits, 2012
Inhibitory neurons are critical for regulating effective transfer of sensory information and network stability. The precision of inhibitory function likely derives from the existence of a variety of interneuron subtypes.
Xavier H. Jaglin, Jens eHjerling-Leffler, Gord eFishell, Gord eFishell, Renata eBatista-Brito, Renata eBatista-Brito   +5 more
doaj   +1 more source