Results 101 to 110 of about 1,294,563 (307)

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Degree of synchronization modulated by inhibitory neurons in clustered excitatory-inhibitory recurrent networks

, 2018
An excitatory-inhibitory recurrent neuronal network is established to numerically study the effect of inhibitory neurons on the synchronization degree of neuronal systems.
Xiaojuan Sun, Jinghua Xiao, Huiyan Li
core   +1 more source

Afferent Neuronal Control of Type-I Gonadotropin Releasing Hormone Neurons in the Human. [PDF]

, 2013
Understanding the regulation of the human menstrual cycle represents an important ultimate challenge of reproductive neuroendocrine research. However, direct translation of information from laboratory animal experiments to the human is often complicated ...
Zsolt Liposits, Hrabovszky, Erik, Liposits, Zsolt, Erik Hrabovszky   +3 more
core   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Population activity structure of excitatory and inhibitory neurons. [PDF]

, 2017
Many studies use population analysis approaches, such as dimensionality reduction, to characterize the activity of large groups of neurons. To date, these methods have treated each neuron equally, without taking into account whether neurons are ...
Adam C Snyder, Ashok Litwin-Kumar, Ryan C Williamson, Williamson, Ryan C., Byron M Yu, Snyder, Adam C., Matthew A. Smith, Sean R Bittner, Ryan C. Williamson, Brent Doiron, Steven M. Chase, Byron M. Yu, Chase, Steven M., Matthew A Smith, Bittner, Sean R., Litwin Kumar, Ashok, Yu, Byron M., Adam C. Snyder, Steven M Chase, Doiron, Brent, Sean R. Bittner, Smith, Matthew A.   +21 more
core   +2 more sources

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Exact firing time statistics of neurons driven by discrete inhibitory noise [PDF]

, 2017
International audienceNeurons in the intact brain receive a continuous and irregular synaptic bombardment from excitatory and inhibitory pre- synaptic neurons, which determines the firing activity of the stimulated neuron.
Alessandro Torcini, Angulo-Garcia, David, David Angulo-Garcia, Olmi, Simona, Torcini, Alessandro, Simona Olmi, Alberto Imparato, Imparato, Alberto, David Angulo Garcia   +8 more
core   +1 more source

GABA-Glycine Cotransmitting Neurons in the Ventrolateral Medulla: Development and Functional Relevance for Breathing

Frontiers in Cellular Neuroscience, 2019
Inhibitory neurons crucially contribute to shaping the breathing rhythm in the brain stem. These neurons use GABA or glycine as neurotransmitter; or co-release GABA and glycine.
Johannes Hirrlinger, Johannes Hirrlinger, Grit Marx, Stefanie Besser, Marit Sicker, Susanne Köhler, Petra G. Hirrlinger, Sonja M. Wojcik, Volker Eulenburg, Ulrike Winkler, Swen Hülsmann, Swen Hülsmann   +11 more
doaj   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Dendritic calcium accumulation associated with direction-selective adaptation in visual motion-sensitive neurons in vivo [PDF]

, 2000
Kurtz R, Dürr V, Egelhaaf M. Dendritic calcium accumulation associated with direction-selective adaptation in visual motion-sensitive neurons in vivo. Journal of Neurophysiology.
Egelhaaf, Martin ; https://orcid.org/, Rafael Kurtz, Martin Egelhaaf, Martin Egelhaaf Dendritic Calcium, Kurtz, Rafael, Dürr, Volker ; https://orcid.org/, Volker Dürr   +6 more
core   +1 more source